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Plasma miR-122 as a potential diagnostic and prognostic indicator in human glioma

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Abstract

Gliomas are the most common and aggressive brain tumors, and a poor prognosis is correlated with its World Health Organization (WHO) grade. MicroRNAs (miRNAs) may serve as diagnostic and prognostic biomarkers in gliomas. In the present study, we collected plasma samples from patients with gliomas to evaluate the expression of miR-122 and analyzed the role of miR-122 in the diagnosis and prognosis of gliomas. We found that the expression of miR-122 in the plasma of patients with gliomas was significantly down-regulated compared to that in healthy individuals. In addition, the expression of miR-122, which was significantly correlated with WHO grade, decreased along with the development of gliomas. A receiver operating characteristic curve analysis showed high sensitivity and specificity of miR-122 for diagnosing gliomas (sensitivity 91.9%; specificity 81.1%; area under the curve 0.939). Finally, we found that lower expression of miR-122 was correlated with poor prognosis, and miR-122 was an independent prognostic parameter indicating poor prognosis for gliomas. In conclusion, our results showed that plasma miR-122 expression might act as a diagnostic and prognostic biomarker for gliomas.

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Author notes

    Authors and Affiliations

    1. Zaozhuang Hospital of Zaozhuang Mining Group, NO.188 Shengli Road, Zaozhuang, 277101, People’s Republic of China

      Ying Tang

    2. The Third People’s Hospital of Liaocheng, No. 62 Weiyu Road, Liaocheng, 252000, People’s Republic of China

      Shunfeng Zhao

    3. Central Hospital of Shengli Oilfield, No. 31 Jinan Road, Dongying, 257034, People’s Republic of China

      Jiliang Wang & Yurong Tang

    4. Juye County People’s Hospital, No. 3 Wenhua Road, Heze, 274900, People’s Republic of China

      Dongfeng Li

    5. The Sixth People’s Hospital of Qingdao, No. 9 Fushun Road, Qingdao, 266003, People’s Republic of China

      Qingbo Ren

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    1. Ying Tang
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    2. Shunfeng Zhao
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    Correspondence to Qingbo Ren or Yurong Tang.

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    The authors declare that they have no conflict of interest.

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    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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    Informed consent was obtained from all individual participants included in the study.

    Additional information

    Ying Tang and Shunfeng Zhao contributed equally to this work.

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    Tang, Y., Zhao, S., Wang, J. et al. Plasma miR-122 as a potential diagnostic and prognostic indicator in human glioma. Neurol Sci 38, 1087–1092 (2017). https://doi.org/10.1007/s10072-017-2912-y

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    • DOI: https://doi.org/10.1007/s10072-017-2912-y

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