Skip to main content
SpringerLink
Log in

Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Rapid eye movement sleep behavior disorder (RBD) is thought to be one of the most frequent preceding symptoms of Parkinson’s disease (PD). However, the prevalence of RBD in PD stated in the published studies is still inconsistent. We conducted a meta and meta-regression analysis in this paper to estimate the pooled prevalence. We searched the electronic databases of PubMed, ScienceDirect, EMBASE and EBSCO up to June 2016 for related articles. STATA 12.0 statistics software was used to calculate the available data from each research. The prevalence of RBD in PD patients in each study was combined to a pooled prevalence with a 95 % confidence interval (CI). Subgroup analysis and meta-regression analysis were performed to search for the causes of the heterogeneity. A total of 28 studies with 6869 PD cases were deemed eligible and included in our meta-analysis based on the inclusion and exclusion criteria. The pooled prevalence of RBD in PD was 42.3 % (95 % CI 37.4–47.1 %). In subgroup analysis and meta-regression analysis, we found that the important causes of heterogeneity were the diagnosis criteria of RBD and age of PD patients (P = 0.016, P = 0.019, respectively). The results indicate that nearly half of the PD patients are suffering from RBD. Older age and longer duration are risk factors for RBD in PD. We can use the minimal diagnosis criteria for RBD according to the International Classification of Sleep Disorders to diagnose RBD patients in our daily work if polysomnography is not necessary.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW (1986) Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 9(2):293–308

    CAS  PubMed  Google Scholar 

  2. Plazzi G (2004) REM sleep behavior disorders in Parkinson’s disease and other Parkinsonian disorders. Sleep Med 5(2):195–199. doi:10.1016/j.sleep.2004.01.003

    Article  PubMed  Google Scholar 

  3. Mollenhauer B, Zimmermann J, Sixel-Doring F, Focke NK, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Trautmann E, Zetterberg H, Taylor P, Friede T, Trenkwalder C, DeNoPa Study G (2016) Monitoring of 30 marker candidates in early Parkinson disease as progression markers. Neurology. doi:10.1212/WNL.0000000000002651

    PubMed Central  Google Scholar 

  4. Fereshtehnejad SM, Romenets SR, Anang JB, Latreille V, Gagnon JF, Postuma RB (2015) New clinical subtypes of parkinson disease and their longitudinal progression: a prospective cohort comparison with other phenotypes. JAMA Neurol 72(8):863–873. doi:10.1001/jamaneurol.2015.0703

    Article  PubMed  Google Scholar 

  5. Zhang JR, Chen J, Yang ZJ, Zhang HJ, Fu YT, Shen Y, He PC, Mao CJ, Liu CF (2016) Rapid eye movement sleep behavior disorder symptoms correlate with domains of cognitive impairment in parkinson’s disease. Chin Med J 129(4):379–385. doi:10.4103/0366-6999.176077

    Article  PubMed  PubMed Central  Google Scholar 

  6. Arnaldi D, Morbelli S, Brugnolo A, Girtler N, Picco A, Ferrara M, Accardo J, Buschiazzo A, de Carli F, Pagani M, Nobili F (2016) Functional neuroimaging and clinical features of drug naive patients with de novo Parkinson’s disease and probable RBD. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2016.05.031

    PubMed  Google Scholar 

  7. Nihei Y, Takahashi K, Koto A, Mihara B, Morita Y, Isozumi K, Ohta K, Muramatsu K, Gotoh J, Yamaguchi K, Tomita Y, Sato H, Seki M, Iwasawa S, Suzuki N (2012) REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire. J Neurol 259(8):1606–1612. doi:10.1007/s00415-011-6386-1

    Article  PubMed  Google Scholar 

  8. Kotagal V, Albin RL, Muller ML, Koeppe RA, Chervin RD, Frey KA, Bohnen NI (2012) Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease. Ann Neurol 71(4):560–568. doi:10.1002/ana.22691

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bjornara KA, Dietrichs E, Toft M (2013) REM sleep behavior disorder in Parkinson’s disease—is there a gender difference? Parkinsonism Relat Disord 19(1):120–122. doi:10.1016/j.parkreldis.2012.05.027

    Article  PubMed  Google Scholar 

  10. Suzuki K, Miyamoto T, Miyamoto M, Watanabe Y, Suzuki S, Tatsumoto M, Iwanami M, Sada T, Kadowaki T, Numao A, Hashimoto K, Sakuta H, Hirata K (2013) Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson’s disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire. BMC Neurol 13:18. doi:10.1186/1471-2377-13-18

    Article  PubMed  PubMed Central  Google Scholar 

  11. Poryazova R, Oberholzer M, Baumann CR, Bassetti CL (2013) REM sleep behavior disorder in Parkinson’s disease: a questionnaire-based survey. J Clin Sleep Med 9(1):55A–59A. doi:10.5664/jcsm.2340

    Google Scholar 

  12. Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, Hu MT (2014) REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson’s disease. J Neurol Neurosurg Psychiatry 85(5):560–566. doi:10.1136/jnnp-2013-306104

    Article  PubMed  Google Scholar 

  13. Mahale R, Yadav R, Pal PK (2014) Rapid eye movement sleep behaviour disorder in young- and older-onset Parkinson disease: a questionnaire-based study. Sleep Med 15(6):642–646. doi:10.1016/j.sleep.2014.01.022

    Article  CAS  PubMed  Google Scholar 

  14. Swallow DM, Lawton MA, Grosset KA, Malek N, Smith CR, Bajaj NP, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams N, Wood NW, Grosset DG, Consortium PRC (2016) Variation in recent onset Parkinson’s Disease: implications for prodromal detection. J Parkinson’s Dis 6(2):289–300. doi:10.3233/JPD-150741

    Article  Google Scholar 

  15. Chahine LM, Xie SX, Simuni T, Tran B, Postuma R, Amara A, Oertel WH, Iranzo A, Scordia C, Fullard M, Linder C, Purri R, Darin A, Rennert L, Videnovic A, Del Riva P, Weintraub D (2016) Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder. Parkinsonism Relat Disord 27:102–106. doi:10.1016/j.parkreldis.2016.03.006

    Article  CAS  PubMed  Google Scholar 

  16. Kim CS, Sung YH, Kang MJ, Park KH (2016) Rapid eye movement sleep behavior disorder in Parkinson’s disease: a preliminary study. J Mov Disord 9(2):114–119. doi:10.14802/jmd.15039

    Article  PubMed  PubMed Central  Google Scholar 

  17. Lee JE, Kim KS, Shin HW, Sohn YH (2010) Factors related to clinically probable REM sleep behavior disorder in Parkinson disease. Parkinsonism Relat Disord 16(2):105–108. doi:10.1016/j.parkreldis.2009.08.005

    Article  PubMed  Google Scholar 

  18. Vibha D, Shukla G, Singh S, Goyal V, Srivastava AK, Behari M (2010) Lower prevalence of sleep disturbances in familial versus sporadic Parkinson’s disease: a questionnaire based study. J Neurol Sci 295(1–2):27–30. doi:10.1016/j.jns.2010.05.024

    Article  PubMed  Google Scholar 

  19. Bugalho P, da Silva JA, Neto B (2011) Clinical features associated with REM sleep behavior disorder symptoms in the early stages of Parkinson’s disease. J Neurol 258(1):50–55. doi:10.1007/s00415-010-5679-0

    Article  PubMed  Google Scholar 

  20. Vibha D, Shukla G, Goyal V, Singh S, Srivastava AK, Behari M (2011) RBD in Parkinson’s disease: a clinical case control study from North India. Clin Neurol Neurosurg 113(6):472–476. doi:10.1016/j.clineuro.2011.02.007

    Article  PubMed  Google Scholar 

  21. Kim YE, Yang HJ, Yun JY, Kim HJ, Lee JY, Jeon BS (2014) REM sleep behavior disorder in Parkinson disease: association with abnormal ocular motor findings. Parkinsonism Relat Disord 20(4):444–446. doi:10.1016/j.parkreldis.2013.12.003

    Article  PubMed  Google Scholar 

  22. Munhoz RP, Teive HA (2014) REM sleep behaviour disorder: how useful is it for the differential diagnosis of parkinsonism? Clin Neurol Neurosurg 127:71–74. doi:10.1016/j.clineuro.2014.09.014

    Article  PubMed  Google Scholar 

  23. Kim YE, Jeon BS, Yang HJ, Ehm G, Yun JY, Kim HJ, Kim JM (2014) REM sleep behavior disorder: association with motor complications and impulse control disorders in Parkinson’s disease. Parkinsonism Relat Disord 20(10):1081–1084. doi:10.1016/j.parkreldis.2014.03.022

    Article  PubMed  Google Scholar 

  24. Nomura T, Inoue Y, Takigawa H, Nakashima K (2012) Comparison of REM sleep behaviour disorder variables between patients with progressive supranuclear palsy and those with Parkinson’s disease. Parkinsonism Relat Disord 18(4):394–396. doi:10.1016/j.parkreldis.2011.10.018

    Article  PubMed  Google Scholar 

  25. Nomura T, Inoue Y, Hogl B, Uemura Y, Yasui K, Sasai T, Namba K, Nakashima K (2011) Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinson’s disease and multiple system atrophy. Psychiatry Clin Neurosci 65(3):264–271. doi:10.1111/j.1440-1819.2011.02201.x

    Article  PubMed  Google Scholar 

  26. Ferri R, Fulda S, Cosentino FI, Pizza F, Plazzi G (2012) A preliminary quantitative analysis of REM sleep chin EMG in Parkinson’s disease with or without REM sleep behavior disorder. Sleep Med 13(6):707–713. doi:10.1016/j.sleep.2012.01.003

    Article  PubMed  Google Scholar 

  27. Romenets SR, Gagnon JF, Latreille V, Panniset M, Chouinard S, Montplaisir J, Postuma RB (2012) Rapid eye movement sleep behavior disorder and subtypes of Parkinson’s disease. Mov Disor 27(8):996–1003. doi:10.1002/mds.25086

    Article  Google Scholar 

  28. Plomhause L, Dujardin K, Duhamel A, Delliaux M, Derambure P, Defebvre L, Monaca Charley C (2013) Rapid eye movement sleep behavior disorder in treatment-naive Parkinson disease patients. Sleep Med 14(10):1035–1037. doi:10.1016/j.sleep.2013.04.018

    Article  PubMed  Google Scholar 

  29. Ferri R (2012) The time structure of leg movement activity during sleep: the theory behind the practice. Sleep Med 13(4):433–441. doi:10.1016/j.sleep.2011.10.027

    Article  PubMed  Google Scholar 

  30. Gong Y, Xiong KP, Mao CJ, Shen Y, Hu WD, Huang JY, Han F, Chen R, Liu CF (2014) Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Med 15(6):647–653. doi:10.1016/j.sleep.2013.12.021

    Article  PubMed  Google Scholar 

  31. Chahine LM, Kauta SR, Daley JT, Cantor CR, Dahodwala N (2014) Surface EMG activity during REM sleep in Parkinson’s disease correlates with disease severity. Parkinsonism Relat Disord 20(7):766–771. doi:10.1016/j.parkreldis.2014.04.011

    Article  PubMed  PubMed Central  Google Scholar 

  32. Alatriste-Booth V, Rodriguez-Violante M, Camacho-Ordonez A, Cervantes-Arriaga A (2015) Prevalence and correlates of sleep disorders in Parkinson’s disease: a polysomnographic study. Arq Neuropsiquiatr 73(3):241–245. doi:10.1590/0004-282X20140228

    Article  PubMed  Google Scholar 

  33. Bayard S, Dauvilliers Y, Yu H, Croisier-Langenier M, Rossignol A, Charif M, Geny C, Carlander B, Cochen De Cock V (2014) Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson’s disease. ParkinsonismRelat Disord 20(12):1411–1414. doi:10.1016/j.parkreldis.2014.09.020

    Article  Google Scholar 

  34. Neikrug AB, Avanzino JA, Liu L, Maglione JE, Natarajan L, Corey-Bloom J, Palmer BW, Loredo JS, Ancoli-Israel S (2014) Parkinson’s disease and REM sleep behavior disorder result in increased non-motor symptoms. Sleep Med 15(8):959–966. doi:10.1016/j.sleep.2014.04.009

    Article  PubMed  PubMed Central  Google Scholar 

  35. American Academy of Sleep Medicine (2001) International classification of sleep disorders. Diagnostic and Coding Manual. American Academy of Sleep Medicine, Westchester

    Google Scholar 

  36. American Academy of Sleep Medicine (2005) International classification of sleep disorders. Diagnostic and coding manual, 2nd edn. American Academy of Sleep Medicine, Westchester

    Google Scholar 

  37. Zintzaras E, Ioannidis JP (2005) Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 28(2):123–137. doi:10.1002/gepi.20048

    Article  PubMed  Google Scholar 

  38. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295(6):676–680. doi:10.1001/jama.295.6.676

    Article  CAS  PubMed  Google Scholar 

  39. Scaglione C, Vignatelli L, Plazzi G, Marchese R, Negrotti A, Rizzo G, Lopane G, Bassein L, Maestri M, Bernardini S, Martinelli P, Abbruzzese G, Calzetti S, Bonuccelli U, Provini F, Coccagna G, Bologna GP, Pisa Universities group for the study of REMSBDiPsD (2005) REM sleep behaviour disorder in Parkinson’s disease: a questionnaire-based study. Neurol Sci 25(6):316–321. doi:10.1007/s10072-004-0364-7

    Article  CAS  PubMed  Google Scholar 

  40. Zhao QF, Tan L, Wang HF, Jiang T, Tan MS, Tan L, Xu W, Li JQ, Wang J, Lai TJ, Yu JT (2016) The prevalence of neuropsychiatric symptoms in Alzheimer’s disease: systematic review and meta-analysis. J Affect Disord 190:264–271. doi:10.1016/j.jad.2015.09.069

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to acknowledge the investigators for their helpful comments on this paper. This work was supported by Grants from Natural Science Foundation of China (81571225).

Author information

Authors and Affiliations

  1. Department of Neurology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong, People’s Republic of China

    Xiaona Zhang, Xiaoxuan Sun, Junhong Wang, Liou Tang & Anmu Xie

Authors
  1. Xiaona Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoxuan Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Junhong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liou Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anmu Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Liou Tang or Anmu Xie.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, X., Sun, X., Wang, J. et al. Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis. Neurol Sci 38, 163–170 (2017). https://doi.org/10.1007/s10072-016-2744-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-016-2744-1

Keywords

Search

Navigation