Abstract
The study aimed to investigate the correlation between Parkinson’s disease (PD) and serum levels of uric acid (UA), albumin and their interaction. A cross-sectional study was conducted to evaluate the relationship of serum UA, albumin with PD. A total of 96 PD patients and 108 healthy controls were recruited at Huai’an First People’s Hospital, Nanjing Medical University. Baseline data included age, gender, body mass index (BMI), disease duration, Hoehn and Yahr scale (H&Y) stage, serum UA and albumin levels. The levels of serum UA and albumin were significantly lower in PD patients than those in controls (P = 0.001; P = 0.000). Serum albumin levels were strikingly different in H&Y group (P = 0.004). Multivariable logistic regression showed that the levels of serum UA (P = 0.001, adjusted OR 0.993, 95% CI 0.988–0.997) and albumin (P = 0.000, adjusted OR 0.513, 95% CI 0.425–0.620) were independent risk factors in PD. The receiver operating characteristic (ROC) curve analyses showed that the area under curve (AUC) for serum UA and albumin was 0.669 (95% CI 0.594–0.744) and 0.883 (95% CI 0.835–0.931), respectively. The combination of serum albumin and UA improved the AUC to 0.898 (95% CI 0.854–0.942). Serum UA and albumin levels significantly decreased in PD patients and were independent risk factors for PD. More studies are needed to confirm our findings.
Similar content being viewed by others
References
Jenner P (2003) Oxidative stress in Parkinson’s disease. Ann Neurol 53(Suppl 3):S26–S36. doi:10.1002/ana.10483 (discussion S36–28)
Schlesinger I, Schlesinger N (2008) Uric acid in Parkinson’s disease. Mov Disord: Off J Mov Disord Soc 23(12):1653–1657. doi:10.1002/mds.22139
Zhu TG, Wang XX, Luo WF et al (2012) Protective effects of urate against 6-OHDA-induced cell injury in PC12 cells through antioxidant action. Neurosci Lett 506(2):175–179. doi:10.1016/j.neulet.2011.10.075
Jesus S, Perez I, Caceres-Redondo MT et al (2013) Low serum uric acid concentration in Parkinson’s disease in southern Spain. Eur J Neurol 20(1):208–210. doi:10.1111/j.1468-1331.2012.03745.x
Annanmaki T, Muuronen A, Murros K (2007) Low plasma uric acid level in Parkinson’s disease. Mov Disord: Off J Mov Disord Soc 22(8):1133–1137. doi:10.1002/mds.21502
Jain S, Ton TG, Boudreau RM et al (2011) The risk of Parkinson disease associated with urate in a community-based cohort of older adults. Neuroepidemiology 36(4):223–229. doi:10.1159/000327748
Chen H, Mosley TH, Alonso A et al (2009) Plasma urate and Parkinson’s disease in the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol 169(9):1064–1069. doi:10.1093/aje/kwp033
Weisskopf MG, O’Reilly E, Chen H et al (2007) Plasma urate and risk of Parkinson’s disease. Am J Epidemiol 166(5):561–567. doi:10.1093/aje/kwm127
Ferro JM, Davalos A (2006) Other neuroprotective therapies on trial in acute stroke. Cerebrovasc Dis 21(Suppl 2):127–130. doi:10.1159/000091712
Peng F, Yang Y, Liu J et al (2012) Low antioxidant status of serum uric acid, bilirubin and albumin in patients with neuromyelitis optica. Eur J Neurol 19(2):277–283. doi:10.1111/j.1468-1331.2011.03488.x
Xu WH, Dong C, Rundek T et al (2014) Serum albumin levels are associated with cardioembolic and cryptogenic ischemic strokes: Northern Manhattan Study. Stroke; J Cereb Circ 45(4):973–978. doi:10.1161/STROKEAHA.113.003835
Hostmark AT, Tomten SE (2006) Serum albumin and self-reported prevalence of stroke: a population-based, cross-sectional study. Eur J Cardiovasc Prev Rehabil: Off J Eur Soc Cardiol Work Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol 13(1):87–90
Gillum RF, Ingram DD, Makuc DM (1994) Relation between serum albumin concentration and stroke incidence and death: the NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 140(10):876–888
Kim TH, Lee JH (2014) Serum uric acid and nigral iron deposition in Parkinson’s disease: a pilot study. PLoS One 9(11):e112512. doi:10.1371/journal.pone.0112512
Zhang HN, Guo JF, He D et al (2012) Lower serum UA levels in Parkinson’s disease patients in the Chinese population. Neurosci Lett 514(2):152–155. doi:10.1016/j.neulet.2012.02.077
Regoli F, Winston GW (1999) Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals. Toxicol Appl Pharmacol 156(2):96–105. doi:10.1006/taap.1999.8637
Skinner KA, White CR, Patel R et al (1998) Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor. J Biol Chem 273(38):24491–24497
Grimm G, Haslacher H, Kampitsch T et al (2009) Sex differences in the association between albumin and all-cause and vascular mortality. Eur J Clin Investig 39(10):860–865. doi:10.1111/j.1365-2362.2009.02189.x
Idicula TT, Waje-Andreassen U, Brogger J et al (2009) Serum albumin in ischemic stroke patients: the higher the better. The Bergen Stroke Study. Cerebrovasc Dis 28(1):13–17. doi:10.1159/000215938
Taverna M, Marie AL, Mira JP et al (2013) Specific antioxidant properties of human serum albumin. Ann Intensive Care 3(1):4. doi:10.1186/2110-5820-3-4
Zhang WJ, Frei B (2002) Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells. Cardiovasc Res 55(4):820–829
Niranjan R (2014) The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson’s disease: focus on astrocytes. Mol Neurobiol 49(1):28–38. doi:10.1007/s12035-013-8483-x
Bachmann CG, Trenkwalder C (2006) Body weight in patients with Parkinson’s disease. Mov Disord: Off J Mov Disord Soc 21(11):1824–1830. doi:10.1002/mds.21068
Demir MV, Tamer A, Cinemre H et al (2015) Nutritional status and laboratory parameters among internal medicine inpatients. Niger J Clin Pract 18(6):757–761. doi:10.4103/1119-3077.158145
Gao X, O’Reilly EJ, Schwarzschild MA et al (2016) Prospective study of plasma urate and risk of Parkinson disease in men and women. Neurology 86(6):520–526. doi:10.1212/WNL.0000000000002351
Acknowledgements
No funding source was used during the study.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
The authors declare no conflict of interests.
Rights and permissions
About this article
Cite this article
Wang, L., Hu, W., Wang, J. et al. Impact of serum uric acid, albumin and their interaction on Parkinson’s disease. Neurol Sci 38, 331–336 (2017). https://doi.org/10.1007/s10072-016-2738-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-016-2738-z