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Cough headache secondary to spontaneous intracranial hypotension complicated by cerebral venous thrombosis

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Abstract

Cough headache may be the clinical manifestation, sometimes isolated, of an intracranial disease. There are several possible causes of secondary cough headache. The hypothesis that cough headache may be the expression of spontaneous intracranial hypotension has been advanced only recently. In fact, this would represent an exception to the rule that cough headache is generally secondary to conditions leading to an increase in intracranial pressure and/or volume. We report and discuss a case of cough headache secondary to spontaneous intracranial hypotension in an otherwise healthy 59-year-old man. The condition was complicated by cerebral venous thrombosis.

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References

  1. Headache Classification Subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders: 2nd edn. Cephalalgia 24(suppl 1):1–160

    Google Scholar 

  2. Pascual J, Iglesias F, Oterino A, Vázquez-Barquero A, Berciano J (1996) Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases. Neurology 46:1520–1524

    PubMed  CAS  Google Scholar 

  3. Pascual J (2005) Primary cough headache. Curr Pain Headache Rep 9:272–276

    Article  PubMed  Google Scholar 

  4. Pascual J, González-Mandly A, Martín R, Oterino A (2008) Headaches precipitated by cough, prolonged exercise or sexual activity: a prospective etiological and clinical study. J Headache Pain 9:259–266

    Article  PubMed  Google Scholar 

  5. Rasmussen BK, Olesen J (1992) Symptomatic and non symptomatic headaches in a general population. Neurology 42:1225–1231

    PubMed  CAS  Google Scholar 

  6. Chen PK, Fuh JL, Wang SJ (2009) Cough headache: a study of 83 consecutive patients. Cephalalgia 29:1079–1085

    Article  PubMed  Google Scholar 

  7. Symonds C (1956) Cough headache. Brain 76:557–568

    Article  Google Scholar 

  8. Rooke ED (1968) Benign exertional headache. Med Clin North Am 52:801–802

    PubMed  CAS  Google Scholar 

  9. Jacome DE, Stamm MA (2004) Malignant cough headache. Headache 44:259–261

    Article  PubMed  Google Scholar 

  10. Eross EJ, Swanson JW, Krauss WE, Parisi JE (2002) A rare cause of cough headache in an adult. Headache 42:382

    Article  PubMed  Google Scholar 

  11. Smith WS, Messing RO (1993) Cerebral aneurysm presenting as cough headache. Headache 33:203–204

    Article  PubMed  CAS  Google Scholar 

  12. Britton TC, Guiloff RJ (1988) Carotid artery disease presenting as cough headache. Lancet 1:1406–1407

    Article  PubMed  CAS  Google Scholar 

  13. Satikov IN, Mattle HP (1978) Vertebrobasilar dolichoectasia and exertional headache. J Neurol Neurosurg Psychiatry 41:930–933

    Article  Google Scholar 

  14. Williams B (1976) Cerebrospinal fluid pressure changes in response to coughing. Brain 99:331–346

    Article  PubMed  CAS  Google Scholar 

  15. Williams B (1980) Cough headache due to craniospinal pressure dissociation. Arch Neurol 37:226–230

    Article  PubMed  CAS  Google Scholar 

  16. Nightingale S, William B (1987) Hindbrain hernia headache. Lancet 1:731–734

    Article  PubMed  CAS  Google Scholar 

  17. Sansur CA, Heiss JD, De Vroom HL, Eskioglu E, Ennis R, Oldfield EH (2003) Pathophysiology of headache associated with cough in patients with Chiari I malformation. J Neurosurg 98:453–458

    Article  PubMed  Google Scholar 

  18. Evans RW, Boes CJ (2005) Spontaneous low cerebrospinal fluid pressure syndrome can mimic primary cough headache. Headache 45:374–377

    Article  PubMed  Google Scholar 

  19. Nuti A, Baldacci F, Lucetti C, Dolciotti C, Cipriani G, Bonuccelli U (2010) A case of idiopathic low CSF pressure headache presenting as cough headache. Neurol Sci 31:669–672

    Google Scholar 

  20. Mea E, Chiapparini L, Savoiardo M, Franzini A, Bussone G, Leone M (2009) Clinical features and outcomes in spontaneous intracranial hypotension: a survey of 90 consecutive patients. Neurol Sci 30(Suppl 1):S11–S13

    Article  PubMed  Google Scholar 

  21. Mokri B (2004) Spontaneous low cerebrospinal pressure/volume headache. Curr Neurol Neurosci rep 4:117–124

    Article  PubMed  Google Scholar 

  22. Schievink WI, Louy C (2007) Precipitating factors of spontaneous spinal CSF leaks and intracranial hypotension. Neurology 69:700–702

    Article  PubMed  Google Scholar 

  23. Schievink WI, Gordon OK, Tourje J (2004) Connective tissue disorders with spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension: a prospective study. Neurosurgery 54:65–69

    Article  PubMed  Google Scholar 

  24. Messori A, Savolini U (2001) Post-lumbar puncture intracranial hypotension. Neurol Sci 22:411–412

    Article  PubMed  CAS  Google Scholar 

  25. Spelle L, Boulin A, Tainturier C et al (2001) Neuroimaging features of spontaneous intracranial hypotension. Neuroradiology 43:622–627

    Article  PubMed  CAS  Google Scholar 

  26. Atkinson JL, Weinshenker BG, Miller GM, Piepgras DG, Mokri B (1988) Acquired Chiari I malformation secondary to spontaneous spinal cerebrospinal fluid leakage and chronic intracranial hypotension syndrome in seven cases. J Neurosurg 88:237–242

    Google Scholar 

  27. Mokri B (2003) Headache caused by decreased intracranial pressure: diagnosis and management. Curr Opin Neurol 16:319–326

    Article  PubMed  Google Scholar 

  28. Alvarez-Linera J, Escribano J, Benito-Leun J, Porta-Etessam J, Rovina A (2000) Pituitary enlargement in patients with intracranial hypotension syndrome. Neurology 55:1895–1897

    PubMed  CAS  Google Scholar 

  29. Roll JD, Larson TC, Soriano R (2003) Cerebral angiographic findings in spontaneous intracranial hypotension. Am J Neuroradiol 24:707–708

    PubMed  Google Scholar 

  30. Thomas DL, Menda Y, Graham MM (2009) Radionuclide cisternography in detecting cerebrospinal fluid leak in spontaneous intracranial hypotension. Clin Nucl Med 34:410–416

    Article  PubMed  Google Scholar 

  31. Mokri B (2000) Cerebrospinal fluid depletion and its emerging clinical/imaging syndromes. Neurosurgery focus 9:e6

    CAS  Google Scholar 

  32. Fay T (1937) Mechanism of headache. Arch Neurol Psychiatry 37:471–474

    Google Scholar 

  33. Schievink WI, Maya MM (2008) Cerebral venous thrombosis in spontaneous intracranial hypotension. Headache 48:1511–1519

    Article  PubMed  Google Scholar 

  34. Albayram S, Kara B, Ipek H, Ozbayrak M, Kantarci F (2009) Isolated cortical thrombosis associated with intracranial hypotension syndrome. Headache 49:916–919

    Article  PubMed  Google Scholar 

  35. Nardone R, Caleri F, Golaszewski S, Ladurner G, Tezzon F, Bailey A, Trinka E, Zuccoli G (2010) Subdural hematoma in a patient with spontaneous intracranial hypotension and cerebral venous thrombosis. Neurol Sci 31:789–791

    Google Scholar 

  36. Porta-Etessam J, Di Capua D, Jorquera M, Cuadrado ML, Marcos A (2011) Orthostatic headache and bilateral abducens palsy secondary to spontaneous intracranial hypotension. J Headache Pain 12:109–111

    Article  PubMed  Google Scholar 

  37. Ozisik P, Berker M, Onal B (2010) A case of intracranial hypotension complicated with hydrocephalus. Turk Neurosurg 20:550–556

    PubMed  Google Scholar 

  38. Bousser MG, Ferro JM (2007) Cerebral venous thrombosis: an update. Lancet Neurology 6:162–170

    Article  PubMed  CAS  Google Scholar 

  39. Ferrante E, Savino A, Sances G, Nappi G (2004) Spontaneous intracranial hypotension syndrome: report of twelve cases. Headache 44:615–622

    Article  PubMed  Google Scholar 

  40. Gentile S, Lo Giudice R, De Martino P, Rainero I, Pinessi L (2004) Headache attributed to spontaneous low CSF pressure: report of three cases responsive to corticosteroids. Eur J Neurol 11:849–851

    Article  PubMed  CAS  Google Scholar 

  41. Ferrante E, Arpino I, Citterio A, Wetzl R, Savino A (2010) Epidural blood patch in Trendelenburg position pre-medicated with acetazolamide to treat spontaneous intracranial hypotension. Eur J Neurol 17:715–719

    Article  PubMed  CAS  Google Scholar 

  42. Kantor D, Silberstein SD (2005) Cervical epidural blood patch for low CSF pressure headaches. Neurology 65:1138

    Article  PubMed  Google Scholar 

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Ferrante, T., Latte, L., Abrignani, G. et al. Cough headache secondary to spontaneous intracranial hypotension complicated by cerebral venous thrombosis. Neurol Sci 33, 429–433 (2012). https://doi.org/10.1007/s10072-011-0757-3

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  • DOI: https://doi.org/10.1007/s10072-011-0757-3

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