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Vascular endothelial growth factor expression in rat skin incision wound

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Abstract

Vascular endothelial growth factor (VEGF) is a glycoprotein that enhances vascular permeability, induces chemotaxis and activation of monocytes/macrophages, and promotes growth of vascular endothelial cells. We report that infiltrating polymorphonuclear leukocytes in an incision wound in rat skin express VEGF from 1 day after the injury, as shown by immunohistochemistry. VEGF is also present in macrophages, fibroblast-like cells, and endothelial cells 3 and 7 days after the injury. mRNA for VEGF is statistically significantly increased in the wound area in the tissue 1 day after the skin incision compared with 3 and 7 days after the incision. The VEGF protein content in the wound tissue is statistically significantly higher in the wound than in control skin at 1 and 3 days after skin incision. Our results indicate that VEGF is produced by inflammatory cells to induce vascularization in the early stage of the wound healing process.

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Authors and Affiliations

  1. Department of Legal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Makoto Nogami, Tomoaki Hoshi, Mayumi Kinoshita & Tomomi Arai

  2. Central Laboratory for Electron Microscopy, Teikyo University School of Medicine, Tokyo, Japan

    Michiho Takama & Ichiro Takahashi

Authors
  1. Makoto Nogami
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  2. Tomoaki Hoshi
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  3. Mayumi Kinoshita
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  4. Tomomi Arai
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  5. Michiho Takama
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  6. Ichiro Takahashi
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Correspondence to Makoto Nogami.

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Nogami, M., Hoshi, T., Kinoshita, M. et al. Vascular endothelial growth factor expression in rat skin incision wound. Med Mol Morphol 40, 82–87 (2007). https://doi.org/10.1007/s00795-007-0357-8

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  • DOI: https://doi.org/10.1007/s00795-007-0357-8

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