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Thermostable marine microbial proteases for industrial applications: scopes and risks

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Abstract

Thermostable proteases are important in biotechnological and industrial sectors, due to their stability against denaturing agents and chemicals. The feature that gives them such unique applicability is their reaction at high temperatures, which affords a high concentration of substrate, and less risk of microbial contamination. Nearly 65% of industrial proteases are isolated from marine microbial source, and they can significantly resist a wide range of organic solvents at high temperatures. The most important trait of marine organisms is their adaptability, which allows them to grow optimally in harsh environments such as high salt, temperatures, and pressure—the characteristics of deep-sea hot springs and geothermal sediments. However, proteases are immunogenic, and they can trigger inflammatory conditions in human; so their safety assessment prior to industrial usage is of paramount importance. This review focusses on marine-origin thermophilic proteases, their thermal resistance, scopes of their industrial applications, and risks.

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Acknowledgements

The authors would like to declare their appreciation to the research council of the University of Hormozgan. No funding was received for this literature review.

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Authors and Affiliations

  1. Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran

    Noora Barzkar

  2. Department of Biochemistry, Faculty of Sciences, University of Hormozgan, Bandar Abbas, Iran

    Ahmad Homaei

  3. Department of Biology, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran

    Roohullah Hemmati

  4. Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, 92182, USA

    Seema Patel

  5. Department of Biology, Faculty of Sciences, University of Hormozgan, P.O. Box 3995, Bandar Abbas, Iran

    Ahmad Homaei

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  1. Noora Barzkar
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  2. Ahmad Homaei
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Correspondence to Ahmad Homaei.

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Barzkar, N., Homaei, A., Hemmati, R. et al. Thermostable marine microbial proteases for industrial applications: scopes and risks. Extremophiles 22, 335–346 (2018). https://doi.org/10.1007/s00792-018-1009-8

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