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Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins

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Abbreviations

apoTf:

Apotransferrin

GaM:

Tris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium(III)

HEPES:

4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid

HMM:

High molecular mass

HSA:

Human serum albumin

HQ:

8-Hydroxyquinoline

KP46:

Tris(8-quinolinolato)gallium(III)

LMM:

Low molecular mass

PDB:

Protein Data Bank

STD:

Saturation transfer difference

Tf:

Human serum transferrin

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Acknowledgments

This work was supported by the Hungarian Research Foundation OTKA projects PD103905 and PD83600, and by the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TÁMOP-4.2.4.A/2-11/1-2012-0001 “National Excellence Program”.

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, 6720, Hungary

    Éva A. Enyedy, Orsolya Dömötör & Krisztina Bali

  2. MTA-SZTE Bioinorganic Chemistry Research Group, Dóm tér 7, Szeged, 6720, Hungary

    Orsolya Dömötör

  3. Department of Medical Chemistry, University of Szeged, Dóm tér 8, Szeged, 6720, Hungary

    Anasztázia Hetényi

  4. Department of Pharmacy, University of Pisa, 56126, Pisa, Italy

    Tiziano Tuccinardi

  5. Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090, Vienna, Austria

    Bernhard K. Keppler

Authors
  1. Éva A. Enyedy
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  2. Orsolya Dömötör
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  4. Anasztázia Hetényi
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Correspondence to Éva A. Enyedy.

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Enyedy, É.A., Dömötör, O., Bali, K. et al. Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins. J Biol Inorg Chem 20, 77–88 (2015). https://doi.org/10.1007/s00775-014-1211-9

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  • DOI: https://doi.org/10.1007/s00775-014-1211-9

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