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Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic rats

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An Erratum to this article was published on 22 April 2005

Abstract

The in vivo effects of gavage administration of the synthetic, functional biomimetic cation [Cr3O(O2CCH2CH3)6(H2O)3]+ to healthy and type 2 diabetic model rats are described. After 24 weeks of treatment (0–1,000 μg Cr/kg body mass) of healthy Sprague Dawley rats, the cation results in a lowering (P<0.05) of fasting blood plasma low-density lipoprotein (LDL) cholesterol, total cholesterol, triglycerides, and insulin levels and of 2-h plasma insulin and glucose concentrations after a glucose challenge. Zucker obese rats (a model of the early stages of type 2 diabetes) and Zucker diabetic fatty rats (a model for type 2 diabetes) after supplementation (1,000 μg Cr/kg) have lower fasting plasma total, high-density lipoprotein, and LDL cholesterol, triglycerides, glycated hemoglobin, and insulin levels and lower 2-h plasma insulin levels in glucose tolerance tests. The lowering of plasma insulin concentrations with little effect on glucose concentrations suggests that the supplement increases insulin sensitivity. The cation after 12 and 22 or 24 weeks of administration lowers (P<0.05) fasting plasma glycated hemoglobin levels in the Zucker diabetic and Zucker obese rats, respectively, and thus can improve the glucose status of the diabetic models. The effects cannot be attributed to the propionate ligand.

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Abbreviations

HDL:

High-density lipoprotein

LDL:

Low-density lipoprotein

PTP 1B:

Protein tyrosine phosphatase 1B

SD:

Standard deviation

VLDL:

Very low density lipoprotein

ZDF:

Zucker diabetic fatty

ZKO:

Zucker obese

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Acknowledgements

The authors wish to thank Christine Chang, Jelena Hamilton, Allison Pickering, and James A. Neville and the staff of The University of Alabama Animal Care Facility for assistance with the rat studies. Funding was provided by the National Institutes of Health (DK62094–01) (J.B.V.).

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Authors and Affiliations

  1. Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA

    Buffie J. Clodfelder, Bryan M. Gullick & John B. Vincent

  2. USDA ARS Grand Forks Human Nutrition Research Center, POB 9034, Grand Forks, ND, 58202-9034, USA

    Henry C. Lukaski

  3. Department of Human Nutrition and Hospitality Management, The University of Alabama, Tuscaloosa, AL, 35487-0158, USA

    Yasmin Neggers

Authors
  1. Buffie J. Clodfelder
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  2. Bryan M. Gullick
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  3. Henry C. Lukaski
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  4. Yasmin Neggers
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  5. John B. Vincent
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Correspondence to John B. Vincent.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00775-005-0651-7

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Clodfelder, B.J., Gullick, B.M., Lukaski, H.C. et al. Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic rats. J Biol Inorg Chem 10, 119–130 (2005). https://doi.org/10.1007/s00775-004-0618-0

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  • DOI: https://doi.org/10.1007/s00775-004-0618-0

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