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One pot, multicomponent protocol for the synthesis of novel imidazo[1,2-a]pyrimidine-based pyran analogs: a potential biological scaffold

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Abstract

An efficient procedure between imidazo[1,2-a]pyrimidine-2-carbaldehyde, malononitrile, enolizable C–H activated acidic compounds, and sodium carbonate is described for the synthesis of potential biologically active, novel imidazo[1,2-a]pyrimidine-based pyran analogs through one pot, multicomponent reactions at room temperature. This method provided mild reaction conditions, simple purification without column chromatography, and moderate to good yields for the construction of imidazo[1,2-a]pyrimidine-based pyran derivatives. The structures of target compounds were established with different spectroscopic analyses.

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Acknowledgements

I am grateful to Prof. Dr. Mehmet AY for his support.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Tuğba Güngör

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  1. Tuğba Güngör
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Correspondence to Tuğba Güngör.

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Güngör, T. One pot, multicomponent protocol for the synthesis of novel imidazo[1,2-a]pyrimidine-based pyran analogs: a potential biological scaffold. Monatsh Chem 151, 781–789 (2020). https://doi.org/10.1007/s00706-020-02601-w

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  • DOI: https://doi.org/10.1007/s00706-020-02601-w

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