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Facile synthesis of N-acylbenzotriazoles from carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine and triethylamine

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Abstract

A facile, efficient, and economic method toward N-acylbenzotriazoles was reported using 2,4,6-trichloro-1,3,5-triazine in combination with triethylamine as a carboxylic acid activator. Through reacting 1H-benzotriazole with the generated triacylated triazine intermediate, a series of N-acylbenzotriazoles could be rapidly prepared in high yields without column chromatography.

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Acknowledgments

The Center of Excellence for Innovation in Chemistry (PERCH-CIC), and the National Research University Project under Thailand’s Office of the Higher Education Commission are gratefully acknowledged for financial support.

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Authors and Affiliations

  1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand

    Sirawit Wet-osot, Chuthamat Duangkamol, Mookda Pattarawarapan & Wong Phakhodee

Authors
  1. Sirawit Wet-osot
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  2. Chuthamat Duangkamol
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  3. Mookda Pattarawarapan
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  4. Wong Phakhodee
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Corresponding author

Correspondence to Wong Phakhodee.

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Wet-osot, S., Duangkamol, C., Pattarawarapan, M. et al. Facile synthesis of N-acylbenzotriazoles from carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine and triethylamine. Monatsh Chem 146, 959–963 (2015). https://doi.org/10.1007/s00706-014-1408-1

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  • DOI: https://doi.org/10.1007/s00706-014-1408-1

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