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Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice

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Abstract

Human PSGL-1 is a receptor for EV71 that facilitates EV71 entry and replication in mouse cells. We have evaluated the role of human PSGL-1 in EV71 infection in vivo using a transgenic mouse line. Expression of human PSGL-1 failed to enhance infectivity of clinical EV71 strains in mice; however, it promoted replication and symptom severity at an earlier stage in mice upon infection with a mouse-adapted EV71 strain. We therefore conclude that human PSGL-1 alone is not sufficient to modulate infection with the clinical EV71 strains of genotype C4 in mice.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China [31000988/C040602], the National Basic Research Program of China [973 Program, 2011CB504903], and the Ministry of Health Foundation [No. 200802036].

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Authors and Affiliations

  1. Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, China

    Jiangning Liu, Wei Dong, Xiongzhi Quan, Chuan Qin & Lianfeng Zhang

  2. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, CAMS and Comparative Medicine Center, Institute of Laboratory Animal Science, PUMC, Chao Yang Strict, Pan Jia Yuan Nan Li No.5, Beijing, 100021, China

    Chunmei Ma, Chuan Qin & Lianfeng Zhang

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  1. Jiangning Liu
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  2. Wei Dong
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  3. Xiongzhi Quan
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Correspondence to Lianfeng Zhang.

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Liu, J., Dong, W., Quan, X. et al. Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice. Arch Virol 157, 539–543 (2012). https://doi.org/10.1007/s00705-011-1198-2

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  • DOI: https://doi.org/10.1007/s00705-011-1198-2

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