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A novel human adenovirus hexon protein of species D found in an AIDS patient

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Abstract

To date, human adenoviruses are classified into 53 types (types 1–51 and types 53 and 54), which have been grouped into six species named A through F, and the recently identified type 52 has been proposed as member of a new species, G. Type classification is based on type-specific epitopes within loop 1 (L1) and loop 2 (L2) of the hexon protein, which contain seven hypervariable regions that are responsible for type specificity. In this paper, we present the characterization of an adenovirus strain isolated from a male AIDS patient in Cordoba, Argentina. This strain was found to be a member of species D by genomic Sma I restriction analysis. Sequencing of the L1 and L2 regions of the hexon gene and immunological characterization by virus neutralization revealed this hexon to be unique and distinct from the previously identified hexons of types within species D. A seroepidemiologic study in the human population of Cordoba showed that this strain was not endemic in the local human population.

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Acknowledgments

This study was supported by grant from the Secretaria de Ciencia y Tecnica from Universidad Nacional de Cordoba, Argentina. We thank Dr. Teryl Frey for language assistance and Dr. Dean Erdman for providing the prototype Adenovirus strains (type 33) and antisera (types 29, 33, 43-47) from CDC (Atlanta, EE UU).

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Authors and Affiliations

  1. Virology Institute “Dr. J. Vanella”, School of Medical Sciences, National University of Cordoba, Cordoba, Argentina

    Leonardo Ferreyra, Miguel Giordano, Laura Martinez, M. Beatriz Isa, Patricia Barril, Gisela Masachessi, Jorge Pavan & Silvia Nates

  2. Central Laboratory, Sanatorio Allende, Cordoba, Argentina

    Sergio Grutadauria

  3. Instituto de Virología “J. M. Vanella”, National University of Cordoba, Enfermera Gordillo Gómez s/n. Agencia 4, Ciudad Universitaria, Cordoba, Argentina

    Silvia Nates

Authors
  1. Leonardo Ferreyra
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  2. Miguel Giordano
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  3. Laura Martinez
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  4. M. Beatriz Isa
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  5. Patricia Barril
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  6. Gisela Masachessi
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  7. Sergio Grutadauria
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  8. Jorge Pavan
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  9. Silvia Nates
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Correspondence to Silvia Nates.

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Ferreyra, L., Giordano, M., Martinez, L. et al. A novel human adenovirus hexon protein of species D found in an AIDS patient. Arch Virol 155, 27–35 (2010). https://doi.org/10.1007/s00705-009-0539-x

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  • DOI: https://doi.org/10.1007/s00705-009-0539-x

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