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Hemifacial spasm and reinnervation synkinesias: long-term treatment with either Botox® or Dysport®

  • Movement Disorders-Original Article
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Abstract

Botulinum toxin is considered the treatment of choice for hemifacial spasm (HFS) and reinnervation synkinesias (RS). We present 133 patients with HFS (n = 97) and RS (n = 36) who have been treated with either Botox® (n = 78) or Dysport® (n = 55) exclusively for 6 years (range 2–12 years). The Botox® dose was 21 ± 8 MU, the Dysport® dose 46 ± 22 MU. The therapeutic effect started after 7.1 ± 2.3 days and lasted for 12.5 ± 3.9 weeks. It was stable throughout the observation period in 85% of all patients. Adverse effects occurred in 5.4% of injection series. No patient terminated treatment because of unsatisfactory results. Secondary therapy failure did not occur. With an effective conversion ratio of Botox®:Dysport® = 1:2.56 there were no differences between both drugs with respect to therapeutic efficacy and adverse effects thus confirming the hypothesis that there may not be intrinsic differences between both products.

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Authors and Affiliations

  1. Movement Disorders Section, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Katja Kollewe, Bahram Mohammadi, Reinhard Dengler & Dirk Dressler

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  1. Katja Kollewe
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  2. Bahram Mohammadi
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  3. Reinhard Dengler
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  4. Dirk Dressler
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Correspondence to Katja Kollewe.

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Kollewe, K., Mohammadi, B., Dengler, R. et al. Hemifacial spasm and reinnervation synkinesias: long-term treatment with either Botox® or Dysport® . J Neural Transm 117, 759–763 (2010). https://doi.org/10.1007/s00702-010-0409-4

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