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Simultaneous electrochemical determination of dopamine and epinephrine using gold nanocrystals capped with graphene quantum dots in a silica network

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Abstract

Gold nanocrystals (AuNCs) were synthesized by economical and green strategy in aqueous medium by using N[3(trimethoxysilyl)propyl]ethylenediamine (TMSPED) as both a reducing and stabilizing mediator to avoid the aggregation of gold nanocrystals. Then, the AuNCs were capped with graphene quantum dots (GQDs) using an ultrasonic method. The resulting nanocomposites of GQD-TMSPED-AuNCs were characterized by X-ray photoelectron, X-ray diffraction, Raman, UV-vis and FT-IR spectroscopies. The size and shape of the nanocomposites were confirmed by using transmission electron microscopy and atomic force microscopy. The GQD-TMSPED-AuNCs placed on a glassy carbon electrode enable simultaneous determination of dopamine (DA) and epinephrine (EP) with peak potentials at 0.21 and 0.30 V (vs. Ag/AgCl). The response is linear in the 5 nM – 2.1 μM (DA) and 10 nM – 4.0 μM (EP) concentration ranges, with detection limits of 5 and 10 nM, respectively. The sensor shows good selectivity toward DP and EP in the presence of other molecules, facilitating its rapid detection in practical applications.

Schematic representation of gold nanocrystals capped with graphene quantum dots in the modified electrodes for simultaneous detection of dopamine and epinephrine.

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Acknowledgments

The research described herein was financially supported by the Department of Science and Technology, India under Nanomission scheme (SR/NM/NS-1024/2016). The authors V. Vinoth and H. Valdés gratefully acknowledge to Chile CONICYT/FONDECYT Post-doctoral project no. 3190256, for the financial assistance.

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Authors and Affiliations

  1. Nanomaterials and Solar Energy Conversion Lab, Department of Chemistry, National Institute of Technology, Tiruchirappalli, 620 015, India

    Victor Vinoth, Lakshmi Nochur Natarajan & Sambandam Anandan

  2. Laboratorio de Tecnologías Limpias, Facultad de Ingeniería, Universidad Católica de la Santísima Concepción, Concepción, Chile

    Victor Vinoth & Héctor Valdés

  3. Advanced Ceramics and Nanotechnology Laboratory, Department of Materials Engineering, University of Concepcion, Concepcion, Chile

    Ramalinga Viswanathan Mangalaraja

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  1. Victor Vinoth
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  2. Lakshmi Nochur Natarajan
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Correspondence to Héctor Valdés or Sambandam Anandan.

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Vinoth, V., Natarajan, L.N., Mangalaraja, R.V. et al. Simultaneous electrochemical determination of dopamine and epinephrine using gold nanocrystals capped with graphene quantum dots in a silica network. Microchim Acta 186, 681 (2019). https://doi.org/10.1007/s00604-019-3779-9

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  • DOI: https://doi.org/10.1007/s00604-019-3779-9

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