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Core-shell nanoparticles coated with molecularly imprinted polymers: a review

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Abstract

Core-shell surface molecular imprinting technology represents a rather new trend in analytical sciences. In this kind of material, the imprinting sites are located on the surface of the cores or shells of nanoparticles (NPs). This material can improve the capability of recognizing target molecules (analytes), reduce nonspecific adsorption, increase the relative adsorption capacity and selectivity, and accelerate the rate of mass transfer. This review (with 158 references) focuses on recent trends in core-shell MIPs. Following an introduction into the field, a first main section covers common core-materials including silica, magnetic NPs, quantum dots (including semiconductor quantum dots and carbon dots), gold and silver nanoclusters, and up-conversion materials. A further section covers the materials and reagents required for preparing MIPs (with subsections on templates, functional monomers, cross-linkers, initiators, and effects of solvent). A next main section covers synthetic approaches such as precipitation polymerization, emulsion polymerization, and grafting approach. A final section gives examples for applications of core-shell MIPs in analytical assays and in sensing.

This review (with 158 references) focuses on recent trends in core-shell nanoparticles coated with molecularly imprinted polymers (core-shell MIPs). Three significant synthesis methods are introduced: precipitation, emulsion and grafting approach. Applications of core-shell MIPs concentrate on solid phase extraction, fluorescent probe, surface-enhanced Raman scattering-based sensors and electrochemical sensors.

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Acknowledgments

This work was financially supported by 2015 annual Jiangsu province environmental protection scientific research subject.

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Authors and Affiliations

  1. Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 210009, China

    Muchuan Niu & Hua He

  2. Faculty of Pharmacy, University of Paris V, 4 Avenue de l’Observatoire, 75006, Paris, France

    Chuong Pham-Huy

  3. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing, 210009, China

    Hua He

  4. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing, 210009, China

    Hua He

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  1. Muchuan Niu
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  3. Hua He
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Niu, M., Pham-Huy, C. & He, H. Core-shell nanoparticles coated with molecularly imprinted polymers: a review. Microchim Acta 183, 2677–2695 (2016). https://doi.org/10.1007/s00604-016-1930-4

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