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Surgery or stereotactic body radiotherapy for elderly stage I lung cancer? A propensity score matching analysis

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Abstract

Purpose

The aim of this study was to compare the outcomes of surgery and stereotactic body radiotherapy (SBRT) for elderly clinical stage I non-small cell lung cancer (NSCLC) patients.

Methods

Patients ≥80 years of age with clinical stage I NSCLC between August 2008 and December 2014 were treated either surgery or SBRT. Propensity score matching was performed to reduce bias in various clinicopathological factors.

Results

Surgery was performed in 57 cases and SBRT in 41 cases. In the surgery group, the operations included 34 lobectomies and 23 sublobar resections. In the SBRT group, 27 cases were given 48 Gy in 4 fractions, and 14 were given 60 Gy in 10 fractions. Similar characteristics were identified in age (82 years), gender (male:female ratio 2:1), tumor size (2.2 cm), carcinoembryonic antigen (3.6 ng/ml), Charlson comorbidity index (1), Glasgow prognostic scale (0), and forced expiratory volume in 1 s (1.7 L) after matching. Before matching, the 5-year overall survival (OS) in surgery (68.3%) was significantly better than that in SBRT (47.4%, p = 0.02), and the 5-year disease-specific survival (DSS) (94.1%, 78.2%, p = 0.17) was not significantly different between the groups. The difference in the 5-year OS became non-significant between the matched pairs (57.0%, 49.1%, p = 0.56).

Conclusions

The outcomes of surgery and SBRT for elderly patients with the early stage NSCLC were roughly the same.

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Authors and Affiliations

  1. Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Takuro Miyazaki, Naoya Yamasaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Ryotaro Kamohara, Go Hatachi & Takeshi Nagayasu

  2. Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Takuya Yamazaki & Daisuke Nakamura

  3. Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan

    Shuntaro Sato

Authors
  1. Takuro Miyazaki
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  2. Takuya Yamazaki
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  3. Daisuke Nakamura
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  10. Takeshi Nagayasu
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Correspondence to Takuro Miyazaki.

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Miyazaki, T., Yamazaki, T., Nakamura, D. et al. Surgery or stereotactic body radiotherapy for elderly stage I lung cancer? A propensity score matching analysis. Surg Today 47, 1476–1483 (2017). https://doi.org/10.1007/s00595-017-1536-4

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  • DOI: https://doi.org/10.1007/s00595-017-1536-4

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