Abstract
Localized malignant mesothelioma in the mediastinum is rare and most known cases have been reported as “localized malignant pericardial mesothelioma.” We report a case of a middle mediastinal tumor, which we were able to resect completely. Histopathological examination of the tumor confirmed that it was a malignant epithelial lymphohistiocytoid mesothelioma. We assumed that the tumor was derived from the pericardium. Local recurrence was detected 1 year after resection, and the patient died of the disease about 2 years later.
Similar content being viewed by others
References
Burke A, Virmani R. Malignant mesothelioma of the pericardium. In: Rosai J, Sobin LH, editors. Tumors of the heart and great vessels. Atlas of tumor pathology, 3rd series, fascicle 16. Washington, DC: Armed Forces Institute of Pathology; 1996. p. 181–194.
Crotty TB, Myers JL, Katzenstein AL, Tazelaar HD, Swensen SJ, Churg A. Localized malignant mesothelioma. A clinicopathologic and flow cytometric study. Am J Surg Pathol 1994;18:357–363.
Erdogan E, Demirkazik FB, Gulsun M, Ariyurek M, Emri S, Sak SD. Incidental localized (solitary) mediastinal malignant mesothelioma. Br J Radiol 2005;78:858–861.
Val-Bernal JF, Figols J, Gomez-Roman JJ. Incidental localized (solitary) epithelial mesothelioma of the pericardium: case report and literature review. Cardiovasc Pathol 2002;11:181–185.
Sane AC, Roggli VL. Curative resection of a well-differentiated papillary mesothelioma of the pericardium. Arch Pathol Lab Med 1995;119:266–267.
Bierhoff E, Pfeifer U. Malignant mesothelioma arising from a benign mediastinal mesothelial cyst. Gen Diagn Pathol 1996;142:59–62.
Shimazaki H, Aida S, Iizuka Y, Yoshizu H, Tamai S. Vacuolated cell mesothelioma of the pericardium resembling liposarcoma: a case report. Hum Pathol 2000;31:767–770.
Antman KH. Current concepts: malignant mesothelioma. N Engl Med 1980;303:200–202.
Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP, et al. Localized malignant mesothelioma. Am J Surg Pathol 2005;29:866–873.
McAllister HA, Hall RJ, Cooley DA. Surgical pathology of tumors and cysts of the heart and pericardium. In: Waller BF, editor. Pathology of the heart and great vessels, New York: Churchill Livingstone; 1988. p. 343–366.
Vandercruysse D, Verschakelen JA, Deneffe G. Localized pleural mesothelioma. J Belge Radiol 1993;76:163–166.
Ojeda HF, Mech K Jr, Hicken WJ. Localized malignant mesothelioma: a case report. Am Surg 1998;64:881–885.
Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21:2636–2644.
Ordóñez NG. Immunohistochemical diagnosis of epithelioid mesotheliomas: a critical review of old markers, new markers. Hum Pathol 2002;33:953–967.
Yao DX, Shia J, Erlandson RA, Klimstra DS. Lymphohistiocytoid mesothelioma: a clinical, immunohistochemical and ultrastructural study of four cases and literature review. Ultrastruct Pathol 2004;28:213–228.
Henderson DW, Attwood HD, Constance TJ, Shilkin KB, Steele RH. Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. Ultrastruct Pathol 1988;12:367–384.
Khalidi HS, Medeiros LJ, Battifora H. Lymphohistiocytoid mesothelioma. An often misdiagnosed variant of sarcomatoid malignant mesothelioma. Am J Clin Pathol 2000;113:649–654.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Akamoto, S., Ono, Y., Ota, K. et al. Localized malignant mesothelioma in the middle mediastinum: Report of a case. Surg Today 38, 635–638 (2008). https://doi.org/10.1007/s00595-007-3679-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00595-007-3679-1