Abstract
Purpose
We studied the inhibitory effects of hypotonic cisplatin on the growth of malignant pleural mesothelioma (MPM) cell lines in vitro, and assessed the effectiveness of intraoperative intrapleural hypotonic cisplatin treatment combined with extrapleural pneumonectomy for patients with this tumor.
Methods
In the in vitro experiments, mesothelioma cell lines were exposed to various concentrations of cisplatin in either saline solution or distilled water for up to 5 min. After 48 h incubation, we calculated the inhibition of cell growth. In the clinical study, five patients with MPM underwent intraoperative intrapleural hypotonic cisplatin treatment combined with extrapleural pneumonectomy.
Results
The hypotonic cisplatin treatment inhibited cell growth at a significantly greater rate than the isotonic cisplatin treatment. Just 1–5 min exposure to 10 µg/ml of hypotonic cisplatin inhibited growth by more than 80%. Clinically, no recurrence was found in four of the five patients after a median follow-up period of 27 months (range: 16–36 months), although contralateral multiple pulmonary metastases were found in one patient 10 months after surgery.
Conclusion
Hypotonic cisplatin treatment is effective against MPM, and should be investigated further.
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References
MR Law A Gregor ME Hodson HJG Bloom MT Warwick (1984) ArticleTitleMalignant mesothelioma of the pleura: a study of 52 treated and 64 untreated patients Thorax 39 255–9 Occurrence Handle1:STN:280:BiuC1MnpvFM%3D Occurrence Handle6426072
DJ Sugarbaker RM Flores MT Jaklitsch WG Richards GM Strauss JM Corson et al. (1999) ArticleTitleResection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients J Thorac Cardiovasc Surg 117 54–65 Occurrence Handle1:STN:280:DyaK1M7gt1Ghug%3D%3D Occurrence Handle9869758
EH Baldini A Recht GM Strauss MM DeCamp SuffixJr SJ Swanson MJ Liptay et al. (1997) ArticleTitlePatterns of failure after trimodality therapy for malignant pleural mesothelioma Ann Thorac Surg 63 334–8 Occurrence Handle1:STN:280:ByiC1crmtFE%3D Occurrence Handle9033296
MJ Byrne JA Davidson AW Musk G Dewar G van Hazel M Buck et al. (1999) ArticleTitleCisplatin and gemcitabine treatment for malignant mesothelioma: A phase II study J Clin Oncol 17 25–30 Occurrence Handle1:CAS:528:DyaK1MXltVyksA%3D%3D Occurrence Handle10458214
S Kasseyet P Astoul C Boutin (1999) ArticleTitleResults of a phase II trial of combined chemotherapy for patients with diffuse malignant mesothelioma of the pleura Cancer 85 1740–9 Occurrence Handle10.1002/(SICI)1097-0142(19990415)85:8<1740::AID-CNCR14>3.0.CO;2-9 Occurrence Handle1:CAS:528:DyaK1MXivFWjtr0%3D Occurrence Handle10223568
Y Ichinose N Hara M Ohta H Asoh T Yano K Maeda et al. (1993) ArticleTitleHypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy in patients with lung cancer J Thorac Cardiovasc Surg 105 1041–6 Occurrence Handle1:STN:280:ByyB2svovFQ%3D Occurrence Handle8388966
Y Ichinose T Yano H Asoh H Yokoyama Y Fukuyama J Miyagi et al. (1997) ArticleTitleIntraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis J Surg Oncol 66 196–200 Occurrence Handle10.1002/(SICI)1096-9098(199711)66:3<196::AID-JSO8>3.0.CO;2-7 Occurrence Handle1:CAS:528:DyaK1cXotFKk Occurrence Handle9369966
VW Rusch (1996) ArticleTitleMeeting report: a proposed new International TNM staging system for malignant pleural mesothelioma from the International Mesothelioma Interest Group Lung Cancer 14 1–12 Occurrence Handle10.1016/0169-5002(95)00508-0 Occurrence Handle1:STN:280:BymB28rlt1A%3D Occurrence Handle8696713
RL Stephen JM Novak EM Jensen C Kablitz SS Buys (1990) ArticleTitleEffect of osmotic pressure on uptake of chemotherapeutic agents by carcinoma cells Cancer Res 50 4704–8 Occurrence Handle1:CAS:528:DyaK3cXlt1Gqur0%3D Occurrence Handle1695124
H Zheng D Fink SB Howell (1997) ArticleTitlePharmacological basis for novel therapeutic strategy based on the use of aquated cisplatin Clin Cancer Res 3 1157–65 Occurrence Handle1:CAS:528:DyaK2sXkvFCgsLk%3D Occurrence Handle9815795
MT Jaklitsch SC Grondin DJ Sugarbaker (2001) ArticleTitleTreatment of malignant mesothelioma World J Surg 25 210–7 Occurrence Handle1:STN:280:DC%2BD3MrhsFClsg%3D%3D Occurrence Handle11338024
EG Butchart T Ashcroft WC Barnsley MP Holden (1976) ArticleTitlePleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura: experience with 29 patients Thorax 31 15–24 Occurrence Handle1:STN:280:CSmC2MvntlE%3D Occurrence Handle1257933
VW Rusch E Venkatraman (1996) ArticleTitleThe importance of surgical staging in the treatment of malignant pleural mesothelioma J Thorac Cardiovasc Surg 111 815–26 Occurrence Handle1:STN:280:BymC1cvjsFE%3D Occurrence Handle8614142
VW Rusch K Rosenzweig E Venkatraman L Leon A Raben L Harrison et al. (2001) ArticleTitleA phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma J Thorac Cardiovasc Surg 122 788–95 Occurrence Handle10.1067/mtc.2001.116560 Occurrence Handle1:STN:280:DC%2BD3MrjsVektQ%3D%3D Occurrence Handle11581615
Y Ichinose R Tsuchiya T Koike T Yasumitsu K Nakamura H Tada et al. (2002) ArticleTitleA prematurely terminated phase III trial of intraoperative intrapleural hypotonic cisplatin treatment in patients with resected non-small cell lung cancer with positive pleural lavage cytology: the incidence of carcinomatous pleuritis after surgical intervention J Thorac Cardiovasc Surg 123 695–9 Occurrence Handle10.1067/mtc.2002.120712 Occurrence Handle11986597
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Tagawa, T., Yoshino, I., Yamaguchi, M. et al. Intrapleural Hypotonic Cisplatin Treatment for Malignant Pleural Mesothelioma: In Vitro Experiments and Clinical Application. Surg Today 36, 135–139 (2006). https://doi.org/10.1007/s00595-005-3132-2
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DOI: https://doi.org/10.1007/s00595-005-3132-2