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Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies

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Abstract

Aims

The relationship between diabetes mellitus and periodontitis has long been discussed, but the conclusion of this relationship was controversial. We conducted this meta-analysis to explore the association between diabetes mellitus and the prevalence of periodontitis.

Methods

PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies reporting associations of periodontitis with diabetes. Gray literature was integrated from the Open-Gray database. Prevalence estimates and odds ratios were extracted by two independent reviewers and synthesized through meta-analyses.

Results

Twenty-seven papers met the inclusion criteria involving 3092 diabetic patients and 23,494 controls. Overall prevalence of periodontitis was 67.8% in diabetics (combined types) and 35.5% in patients without diabetes (OR, 1.85; 95%CI, 1.61–2.11). Probing depth (MD 0.23; 95% CI, 0.17–0.29; I2 = 25%) and plaque index (MD, 0.20; 95% CI, 0.18–0.23; P = 0.59; I2 = 0%) severity scores were significantly greater among the diabetic group.

Conclusions

The prevalence and severity of periodontitis are greater in patients with diabetes than in non-diabetic populations.

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Authors and Affiliations

  1. Department of Stomatology, School of Medicine, The First Affiliated Hospital, Shihezi University, Shihezi, Xinjiang, China

    Mengwen Zheng & Chao Guo

  2. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Cheng Wang

  3. Sheffield Teaching Hospitals NIHR Biomedical Research Centre, Glossop Rd, Sheffield, S10 2JF, UK

    Ali Ali

  4. School of Nursing, Peking University, Beijing, China

    Yi An Shih

  5. Department of Stomatology, The Second Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China

    Qinqin Xie

  6. The Affiliated Hospital of Qingdao University, Qingdao,Shangdong, China

    Chao Guo

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CG helped in analysis and writing manuscript. MZ contributed to design, conduct collection, analysis and writing manuscript. CW involved in design and analysis. AA interpreted the data. YAS revised the work. QX collection the data.

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Correspondence to Chao Guo.

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We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, and there is no professional or other personal interest of any nature or kind in any product, service, and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled “Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies.” The corresponding author signed this statement on behalf of all coauthors to indicate that the above information is true, correct, and complete.

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Zheng, M., Wang, C., Ali, A. et al. Prevalence of periodontitis in people clinically diagnosed with diabetes mellitus: a meta-analysis of epidemiologic studies. Acta Diabetol 58, 1307–1327 (2021). https://doi.org/10.1007/s00592-021-01738-2

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