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Surgical treatment in spine Paget’s disease: a systematic review

  • General Review • SPINE - PAGET DISEASE
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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Paget’s disease of bone (PDB) is a disease characterized by a disorder in the bone metabolism. The spine is the second region affected after the pelvis. Surgical treatment is reserved for cases refractory to medical treatment. We performed a systematic review of patients with Paget disease of bone affecting the spine, treated surgically in the last 30 years. The main objective of the review is to find out indications for surgery, outcomes of these patients and also the standard perioperative management.

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References

  1. Paget J (1877) On a Form of Chronic Inflammation of Bones (Osteitis Deformans). Medico-chirurgical Trans 60(37–64):39

    Google Scholar 

  2. Bolland MJ, Cundy T (2013) Paget’s disease of bone: clinical review and update. J Clin Pathol 66(11):924–927. doi:10.1136/jclinpath-2013-201688

    Article  PubMed  Google Scholar 

  3. Chaffins JA (2007) Paget disease of bone. Radiol Technol 79(1):27–40 quiz 41–23

    PubMed  Google Scholar 

  4. Crandall C (2001) Risedronate: a clinical review. Arch Intern Med 161(3):353–360

    Article  PubMed  CAS  Google Scholar 

  5. Hadjipavlou A, Lander P (1991) Paget disease of the spine. J Bone Joint surg Am 73(9):1376–1381

    PubMed  CAS  Google Scholar 

  6. Smidt WR, Hadjipavlou AG, Lander P, Dzioba RB (1994) An algorithmic approach to the treatment of Paget’s disease of the spine. Orthop Rev 23(9):715–724

    PubMed  CAS  Google Scholar 

  7. Prieto-Alhambra D, Pages-Castella A, Wallace G, Javaid MK, Judge A, Nogues X, Arden NK, Cooper C, Diez-Perez A (2014) Predictors of fracture while on treatment with oral bisphosphonates: a population-based cohort study. J Bone Miner Res Off J Am Soc Bone Miner Res 29(1):268–274. doi:10.1002/jbmr.2011

    Article  CAS  Google Scholar 

  8. Hadjipavlou AG, Gaitanis IN, Kontakis GM (2002) Paget’s disease of the bone and its management. J Bone Joint Surg Br 84(2):160–169

    Article  PubMed  Google Scholar 

  9. Hartman JT, Dohn DF (1966) Paget’s disease of the spine with cord or nerve-root compression. The J Bone Joint Surg Am 48(6):1079–1084

    PubMed  CAS  Google Scholar 

  10. Pedicelli A, Papacci F, Leone A, De Simone C, Meglio M, Bonomo L, Colosimo C (2011) Vertebroplasty for symptomatic monostotic Paget disease. J Vasc Interv Radiol JVIR 22(3):400–403. doi:10.1016/j.jvir.2010.11.031

    Article  PubMed  Google Scholar 

  11. Hadjipavlou A, Shaffer N, Lander P, Srolovitz H (1988) Pagetic spinal stenosis with extradural pagetoid ossification. A case report. Spine 13(1):128–130

    Article  PubMed  CAS  Google Scholar 

  12. Hepgul K, Nicoll JA, Coakham HB (1991) Spinal cord compression due to pagetic spinal stenosis with involvement of extradural soft tissues: a case report. Surg Neurol 35(2):143–146

    Article  PubMed  CAS  Google Scholar 

  13. Hepple S, Getty JM, Douglas DL (1998) Paget’s disease and odontoid peg fracture: a case report. Injury 29(4):323–325

    Article  PubMed  CAS  Google Scholar 

  14. Kremer MA, Fruin A, Larson TC 3rd, Roll J, Weil RJ (2003) Vertebroplasty in focal Paget disease of the spine. Case report. J Neurosurg 99(1 Suppl):110–113

    PubMed  Google Scholar 

  15. Oikonomou A, Birbilis T, Gymnopoulou E, Prassopoulos P (2007) Paget disease of the spine manifested by thoracic and lumbar epidural lipomatosis: magnetic resonance imaging findings. Spine 32(25):E789–E792. doi:10.1097/BRS.0b013e31815b7eb8

    Article  PubMed  Google Scholar 

  16. Tancioni F, Di Ieva A, Levi D, Aimar E, Debernardi A, Colombo P, Gaetani P, Rodriguez YBR (2006) Spinal decompression and vertebroplasty in Paget’s disease of the spine. Surg Neurol 66 (2):189–191; discussion 191. doi:10.1016/j.surneu.2005.11.058

  17. Tessitore E, Luzi M, Lobrinus JA, Samaras N, Trombetti A (2008) Cervical Paget disease of bone with spinal cord compression due to atlanto-axial instability: a case report and review of the literature. Spine 33(3):E85–E89. doi:10.1097/BRS.0b013e3181624bad

    Article  PubMed  Google Scholar 

  18. Devogelaer JP, Geusens P, Daci E, Gielen E, Denhaerynck K, Macdonald K, Hermans C, Vancayzeele S, Abraham I, Boonen S (2014) Remission over 3 years in patients with Paget disease of bone treated with a single intravenous infusion of 5 mg zoledronic acid. Calcif Tissue Int 94(3):311–318. doi:10.1007/s00223-013-9812-9

    Article  PubMed  CAS  Google Scholar 

  19. Rubin DJ, Levin RM (2009) Neurologic complications of Paget disease of bone. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol 15(2):158–166. doi:10.4158/EP.15.2.158

    Google Scholar 

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Correspondence to Alberto Jorge-Mora.

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Jorge-Mora, A., Amhaz-Escanlar, S., Lois-Iglesias, A. et al. Surgical treatment in spine Paget’s disease: a systematic review. Eur J Orthop Surg Traumatol 26, 27–30 (2016). https://doi.org/10.1007/s00590-015-1659-5

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  • DOI: https://doi.org/10.1007/s00590-015-1659-5

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