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Intensified hemodialysis regimens: neglected treatment options for children and adolescents

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Abstract

During recent years, the importance of intensified dialysis regimens has gathered increasing interest, especially after the Hemodialysis (HEMO) Study Group reported that a higher dose of thrice-weekly hemodialysis failed to improve clinical outcomes. Long nocturnal hemodialysis (three to six times per week) or short daily hemodialysis are the currently used forms of intensified dialysis. There is substantial evidence for cardiovascular and quality-of-life improvements as well as financial benefits with intensified hemodialysis. Preliminary experience with daily hemodialysis and hemodiafiltration in children has been reported. Given the continuing shortage of donor organs for kidney transplantation, the increasing incidence of end-stage renal disease (ESRD) and recognition of the deleterious effects of long-lasting ESRD, growth retardation, and poor social rehabilitation, more intensified dialysis regimens are a much-needed therapeutical option in both adults and children.

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Acknowledgement

This work was supported by the Else Kröner Fresenius-Stiftung (P26105//A 26/05) to D.M.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Dominik Müller, Miriam Zimmering & Uwe Querfeld

  2. Division of Nephrology, Toronto General Hospital, University Health Network, Toronto, ON, Canada

    Christopher T. Chan

  3. Division of Nephrology, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Philip A. McFarlane

  4. Humber River Regional Hospital, Department of Medicine, University of Toronto, 200 Church St, Weston, ON, M9N 1N9, Canada

    Andreas Pierratos

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  1. Dominik Müller
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  2. Miriam Zimmering
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  4. Philip A. McFarlane
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  5. Andreas Pierratos
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Correspondence to Dominik Müller.

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Müller, D., Zimmering, M., Chan, C.T. et al. Intensified hemodialysis regimens: neglected treatment options for children and adolescents. Pediatr Nephrol 23, 1729–1736 (2008). https://doi.org/10.1007/s00467-008-0783-4

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  • DOI: https://doi.org/10.1007/s00467-008-0783-4

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