Abstract
Dysphagia is a common clinical feature of lateral medullary syndrome (LMS) and is clinically relevant because it is related to aspiration pneumonia, malnutrition, increased mortality, and prolonged hospital stay. Herein, the pathophysiology, prognosis, and treatment of dysphagia in LMS are reviewed. The pathophysiology, prognosis, and treatment of dysphagia in LMS are closely interconnected. Although the pathophysiology of dysphagia in LMS has not been fully elucidated, previous studies have suggested that the medullary central pattern generators coordinate the pharyngeal phases of swallowing. Investigation of the extensive neural connections of the medulla oblongata is important in understanding the pathophysiologic mechanism of dysphagia in LMS. Previous studies have reported that most patients with dysphagia in LMS have a relatively good prognosis. However, some patients require tube feeding for several months, even years, due to severe dysphagia, and little has been reported about conditions associated with a poor prognosis of dysphagia in LMS. Concerning specific therapeutic modalities for dysphagia in LMS, in addition to general modalities used for dysphagia treatment in stroke patients, non-invasive modalities, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation, as well as invasive modalities, such as botulinum toxin injection, balloon catheter dilatation, and myotomy for relaxation of the cricopharyngeal muscle, have been applied. For the appropriate application of therapeutic modalities, clinicians should be aware of the recovery mechanisms and prognosis of dysphagia in LMS. Further studies on this topic, as well as studies involving large numbers of subjects on specific therapeutic modalities, should be encouraged.
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Abbreviations
- LMS:
-
Lateral medullary syndrome
- NA:
-
Nucleus ambiguus
- NTS:
-
Nucleus tractus solitarius
- rTMS:
-
Repetitive transcranial magnetic stimulation
- tDCS:
-
Transcranial direct current stimulation
- CP:
-
Cricopharyngeal
- UES:
-
Upper esophageal sphincter
- MRI:
-
Magnetic resonance imaging
- BTX-A:
-
Botulinum toxin type A
- DOSS:
-
Dysphagia Outcome and Severity Scale
References
Sacco RL, Freddo L, Bello JA, Odel JG, Onesti ST, Mohr JP. Wallenberg’s lateral medullary syndrome. Arch Neurol. 1993;50:609–14.
Kim JS. Pure lateral medullary infarction: clinical–radiological correlation of 130 acute, consecutive patients. Brain. 2003;126(Pt 8):1864–72.
Cidad P, Boto A, Del Hierro A, Capote M, Noval S, Garcia A, et al. Unilateral punctate keratitis secondary to Wallenberg Syndrome. Korean J Ophthalmol. 2014;28(3):278–83.
Fatima S, Joe MD. Lateral medullary syndrome. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019.
Norrving B, Cronqvist S. Lateral medullary infarction: prognosis in an unselected series. Neurology. 1991;41:244–8.
Jang SH, Kwak SY, Chang CH, Jung YJ, Kim J, Kim SH, et al. Prognostic prediction of dysphagia by analyzing the corticobulbar tract in the early stage of intracerebral hemorrhage. Dysphagia. 2020. https://doi.org/10.1007/s00455-020-10093-3.
Guyomard V, Fulcher RA, Redmayne O, Metcalf AK, Potter JF, Myint PK. Effect of dysphasia and dysphagia on inpatient mortality and hospital length of stay: a database study. J Am Geriatr Soc. 2009;57:2101–6.
Wilson RD. Mortality and cost of pneumonia after stroke for different risk groups. J Stroke Cerebrovasc Dis. 2012;10:61–7.
Lin WC, Huang CY, Lee LF, Chen YW, Ho CH, Sun YT. Initial National Institute of Health Stroke Scale to early predict the improvement of swallowing in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2019. https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.07.013.
Schmidt J, Holas M, Halvorson K, Reding M. Videofluoroscopic evidence of aspiration predicts pneumonia and death but not dehydration following stroke. Dysphagia. 1994;9:7–11.
Kalra L, Smith DH, Crome P. Stroke in patients aged over 75 years: outcome and predictors. Postgrad Med J. 1993;69:33–6.
Vigderman AM, Chavin JM, Kososky C, Tahmoush AJ. Aphagia due to pharyngeal constrictor paresis from acute lateral medullary infarction. J Neurol Sci. 1998;155(2):208–10.
Aydogdu I, Ertekin C, Tarlaci S, Turman B, Kiylioglu N, Secil Y. Dysphagia in lateral medullary infarction (Wallenberg's syndrome): an acute disconnection syndrome in premotor neurons related to swallowing activity? Stroke. 2001;32(9):2081–7.
Martino R, Terrault N, Ezerzer F, Mikulis D, Diamant NE. Dysphagia in a patient with lateral medullary syndrome: insight into the central control of swallowing. Gastroenterology. 2001;121(2):420–6.
Jean A. Brain stem control of swallowing: neuronal network and cellular mechanisms. Physiol Rev. 2001;81(2):929–69.
Crary MA. A direct intervention program for chronic neurogenic dysphagia secondary to brainstem stroke. Dysphagia. 1995;10(1):6–18.
Meng NH, Wang TG, Lien IN. Dysphagia in patients with brainstem stroke: incidence and outcome. Am J Phys Med Rehabil. 2000;79(2):170–5.
Chun MH, Kim D, Chang MC. Comparison of dysphagia outcomes between rostral and caudal lateral medullary infarct patients. Int J Neurosci. 2017;127(11):965–70.
Kim HJ, Lee HJ, Park JW. Clinical course and outcome in patients with severe dysphagia after lateral medullary syndrome. Ther Adv Neurol Disord. 2018;11:1–6.
Kim H, Chung CS, Lee KH, Robbins J. Aspiration subsequent to a pure medullary infarction: lesion sites, clinical variables, and outcome. Arch Neurol. 2000;57(4):478–83.
Gupta H, Banerjee A. Recovery of dysphagia in lateral medullary stroke. Case Rep Neurol Med. 2014;2014:404871.
Hillel MF, Robert WT, John H. case study of dysphagia and aspiration following a brain stem stroke. Top Stroke Rehabil. 1999;6(3):41–5.
Anne MV, Jeffrey MC, Charles K, Albert JT. Aphagia due to pharyngeal constrictor paresis from acute lateral medullary infarction. J Neurol Sci. 1998;155(2):208–10.
Logemann JA, Kahrilas PJ. Relearning to swallow after stroke—application of maneuvers and indirect biofeedback: a case study. Neurology. 1990;40(7):1136–8.
Sruthi SN, Arathy JS, Jayakumar RM, Sapna ES, Padmavathy NS. Persistent post-stroke dysphagia treated with cricopharyngeal myotomy. Ann Indian Acad Neurol. 2016;19(2):249–51.
Verin E, Leroi AM, Marie JP. Restoration of normal swallowing function in wallenberg syndrome by repetitive transcranial magnetic stimulation and surgery. Ann Phys Rehabil Med. 2016;59(5–6):343–5.
Khedr EM, Abo-Elfetoh N. Therapeutic role of rTMS on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction. J Neurol Neurosurg Psychiatry. 2010;81(5):495–9.
Rhee WI, Won SJ, Ko SB. Diagnosis with manometry and treatment with repetitive transcranial magnetic stimulation in dysphagia. Ann Rehabil Med. 2013;37(6):907–12.
Katoh J, Hayakawa M, Ishihara K, Kazumi T. Swallowing rehabilitation using balloon catheter treatment evaluated by videofluorography in an elderly patient with Wallenberg's syndrome. Nihon Ronen Igakkai Zasshi. 2000;37(6):490–4.
Miyamoto J, Niijima K, Kubo Y, Miyazaki H, Iguchi F. Successful treatment of dysphagia due to Wallenberg syndrome using intermittent air stretching method with balloon catheter: a case report. No Shinkei Geka. 2014;42(3):227–31.
Ogata T, Tsuboi Y, Kimura S. Successful early swallowing rehabilitation in a patient with Wallenberg syndrome. J Neurol Sci. 2017;381:869.
Osamu K, Hideto S, Hiroaki N, Ayumi O, Yasuyo M, Rei S, et al. Three cases that presented with prolonged dysphagia, after medulla oblongata infarction that was caused by mechanical damage of the cricopharyngeal muscle during balloon dilatation therapy of the-pharyngo-esophageal segment. Nippon Jibiinkoka Gakkai Kaiho. 2019;122:1140–9.
Schneider I, Potatschnig C, Thomfort WF, Eckel HE. Treatment of dysfunction of the CPM with botulinum A toxin: introduction of a new, noninvasive method. Ann Otol Rhinol Laryngol. 1994;103:31–5.
Kim DY, Park CI, Ohn SH, Moon JY, Chang WH, Park SW. Botulinum toxin type A for poststroke cricopharyngeal muscle dysfunction. Arch Phys Med Rehabil. 2006;87(10):1346–51.
Lee SY, Seo HG, Paik NJ. Botulinum toxin injection for dysphagia: a blinded retrospective videofluoroscopic swallowing study analysis. Am J Phys Med Rehabil. 2009;88:491–4.
Alfonsi E, Restivo DA, Cosentino G, De Icco R, Bertino G, Schindler A, et al. Botulinum toxin is effective in the management of neurogenic dysphagia. Clinical–electrophysiological findings and tips on safety in different neurological disorders. Front Pharmacol. 2017;8:80.
Battel I, Koch I, Biddau F, Carollo C, Piccione F, Meneghello F, et al. Efficacy of botulinum toxin type-A and swallowing treatment for oropharyngeal dysphagia recovery in a patient with lateral medullary syndrome. Eur J Phys Rehabil Med. 2017;53(5):798–801.
Koichiro M, Jeffrey BP. Anatomy and physiology of feeding and swallowing—normal and abnormal. Phys Med Rehabil Clin N Am. 2008;19(4):691–707.
Miller AJ. Neurophysiological basis of swallowing. Dysphagia. 1986;1:91.
Dulak D, Naqvi IA. Neuroanatomy, Cranial Nerve 7 (Facial). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018.
Elliott B, Forshing L. Neuroanatomy, Vagal Nerve Nuclei (Nucleus Vagus). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019.
Ghannam JY, Al Kharazi KA. Neuroanatomy, Cranial Meninges. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019.
Sonne J, Lopez-Ojeda W. Neuroanatomy, Cranial Nerve. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing: 2019.
Bogdana P, Prasanna T. Neuroanatomy, Nucleus Ambiguus. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019.
Shigeyuki M, Yoichiro S, Yasuo H. Dorsal motor nucleus of the vagus. Neuroanatomy and Neurophysiology of the Larynx, pp. 97–102; 2016.
Kim SY, Imama AN. Neuroanatomy, Cranial Nerve 12 (Hypoglossal). StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018.
Duane EH. Neuroanatomy: an atlas of structures, sections, and systems. Philadelphia: Lippincott Williams & Wilkins; 2004.
Nilsson H, Ekberg O, Sjoberg S, Olsson R. Pharyngeal constrictor paresis: an indicator of neurologic disease? Dysphagia. 1999;8:239–43.
Cook IJ. Criopharyngeal function and dysfunction. Dysphagia. 1999;8:244–51.
Kwon M, Lee JH, Kim JS. Dysphagia in unilateral medullary infarction: lateral vs medial lesions. Neurology. 2005;65(5):714–8.
Li X, Wang Y. Lateral medullary infarction with ipsilateral hemiparesis, lemniscal sensation loss and hypoglossal nerve palsy. Neurol Sci. 2014;35(4):633–4.
Cunningham ET, Sawchenko PE. Dorsal medullary pathways subserving oromotor reflexes in the rat: implications for the central neural control of swallowing. J Comp Neurol. 2000;417(4):448–66.
Boughter JD Jr, Mulligan MK, St John SJ, Tokita K, Lu L, Heck DH, et al. Genetic control of a central pattern generator: rhythmic oromotor movement in mice is controlled by a major locus near Atp1a2. PLoS ONE. 2012;7(5):e38169.
Gomes CA Jr, Lustosa SA, Matos D, Andriolo RB, Waisberg DR, Waisberg J. Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances. Cochrane Database Syst Rev. 2010;11:CD008096.
Logemann JA, Kahrilas PJ, Kobara M, Vakil NB. The benefit of head rotation on pharyngoesophageal dysphagia. Arch Phys Med Rehabil. 1989;70(10):767–71.
Tsukamoto Y. CT study of closure of the hemipharynx with head rotation in a case of lateral medullary syndrome. Dysphagia. 2000;15(1):17–8.
Ding R, Larson CR, Logemann JA, Rademaker AW. Surface electromyographic and electroglottographic studies in normal subjects under two swallow conditions: normal and during the Mendelsohn maneuver. Dysphagia. 2002;17:1–12.
Boden K, Hallgren A, Witt HH. Effects of three different swallow maneuvers analyzed by videomanometry. Acta Radiogica. 2006;47:628–33.
Shaker R, Easterling C, Kern M, Nitschke T, Massey B, Daniels S, et al. Rehabilitation of swallowing by exercise in tube-fed patients with pharyngeal dysphagia secondary to abnormal UES opening. Gastroenterology. 2002;122(5):1314–21.
Kunieda K, Kubo S, Fujishima I. New swallowing method to improve pharyngeal passage of a bolus by creating negative pressure in the esophagus-vacuum swallowing. Am J Phys Med Rehabil. 2018;97(9):e81–e8484.
Reimers-Neils L, Logemann J, Larson C. Viscosity effects on EMG activity in normal swallow. Dysphagia. 1994;9:101–6.
Lazarus CL, Logemann JA, Rademaker AW, Kahrilas PJ, Pajak T, Lazar R, et al. Effects of bolus volume, viscosity and repeated swallows in nonstroke subjects and stroke patients. Arch Phys Med Rehabil. 1993;74:1066–70.
Shanahan TK, Logemann JA, Rademaker AW, Pauloski BR, Kahrilas PJ. Chin-down posture effect on aspiration in dysphagic patients. Arch Phys Med Rehabil. 1993;74:736–9.
Bulow M, Olsson R, Ekberg O. Videomanometric analysis of supraglottic swallow, effortful swallow, and chin tuck in patients with pharyngeal dysfunction. Dysphagia. 2001;16:190–5.
Steele CM. Exercise-based approaches to dysphagia rehabilitation. Nestle Nutr Inst Workshop Ser. 2012;72:109–17.
Ludlow CL, Humbert I, Saxon K, Poletto C, Sonies B, Crujido L. Effects of surface electrical stimulation both at rest and during swallowing in chronic pharyngeal Dysphagia. Dysphagia. 2007;22:1–10.
Khedr EM, Abo-Elfetoh N, Rothwell JC. Treatment of poststroke dysphagia with repetitive transcranial magnetic stimulation. Acta Neurol Scand. 2009;119:155–61.
Kim L, Chun MH, Kim BR, Lee SJ. Effect of repetitive transcranial magnetic stimulation on patients with brain injury anddysphagia. Ann Rehabil Med. 2011;35:765–71.
Park JW, Oh JC, Lee JW, Yeo JS, Ryu KH. The effect of 5Hz high-frequency rTMS over contralesional pharyngealmotor cortex in post-stroke oropharyngeal dysphagia: a randomized controlled study. Neurogastroenterol Motil. 2013;25:324–e250.
Lim KB, Lee HJ, Yoo J, Kwon YG. Effect of low-frequency rTMS and NMES on subacute unilateral hemispheric stroke with dysphagia. Ann Rehabil Med. 2014;38:592–602.
Kumar S, Wagner CW, Frayne C, Zhu L, Selim M, Feng W, et al. Noninvasive brain stimulation may improve stroke-related dysphagia: a pilot study. Stroke. 2011;42:1035–40.
Yang EJ, Baek SR, Shin J, Lim JY, Jang HJ, Kim YK, et al. Effects of transcranial direct current stimulation (tDCS) on post-stroke dysphagia. Restor Neurol Neurosci. 2012;30:303–11.
Oshima F, Yokozeki M, Hamanaka M, Imai K, Makino M, Kimura M, et al. Prediction of dysphagia severity: an investigation of the dysphagia patterns in patients with lateral medullary infarction. Intern Med. 2013;52(12):1325–31.
Shigematsu T, Fujishima I, Ohno K. Transcranial direct current stimulation improves swallowing function in stroke patients. Neurorehabil Neural Repair. 2013;27(4):363–9.
Gow D, Rothwell J, Hobson A, Thompson D, Hamdy S. Induction of long-term plasticity in human swallowing motor cortex following repetitive cortical stimulation. Clin Neurophysiol. 1044e;115:1044e51.
Bestmann S, Baudewig J, Siebner HR, Rothwell JC, Frahm J. Functional MRI of the immediate impact of transcranial magnetic stimulation on cortical and subcortical motor circuits. Eur J Neurosci. 1950e;19:1950e62.
Baudewig J, Siebner HR, Bestmann S, Tergau F, Tings T, Paulus W, et al. Functional MRI of cortical activations induced by transcranial magnetic stimulation (TMS). NeuroReport. 2001;12:3543.
Fonteneau C, Redoute J, Haesebaert F, Le Bars D, Costes N, Suaud-Chagny MF, et al. Frontal transcranial direct current stimulation induces dopamine release in the ventral striatum in human. Cereb Cortex. 2018;28(7):2636–46.
Kocdor P, Siegel ER, Tulunay-Ugur OE. Cricopharyngeal dysfunction: a systematic review comparing outcomes of dilatation, botulinum toxin injection, and myotomy. Laryngoscope. 2016;126(1):135–41.
Blitzer A, Brin MF. Use of botulinum toxin for diagnosis and management of cricopharyngeal achalasia. Otolaryngol Head Neck Surg. 1997;116:328–30.
Alberty J, Oelerich M, Ludwig K, Hartmann S, Stoll W. Efficacy of botulinum toxin A for treatment of upper esophageal sphincter dysfunction. Laryngoscope. 2000;110:1151–6.
Haapaniemi JJ, Laurikainen EA, Pulkkinen J, Marttila RJ. Botulinum toxin in the treatment of cricopharyngeal dysphagia. Dysphagia. 2001;16:171–5.
Shaw GY, Searl JP. Botulinum toxin treatment for cricopharyngeal dysfunction. Dysphagia. 2001;16:161–7.
Parameswaran MS, Soliman AMS. Endoscopic botulinum toxin injection for cricopharyngeal dysphagia. Ann Otol Rhinol Laryngol. 2002;111:871–4.
Zaninotto G, Ragona RM, Briani C, Costantini M, Rizzetto C, Portale G, et al. The role of botulinum toxin injection and upper esophageal sphincter myotomy in treating oropharyngeal dysphagia. J Gastrointest Surg. 2004;8:997–1006.
Murry T, Wasserman T, Carrau RL, Castillo B. Injection of botulinum toxin A for the treatment of dysfunction of the upper esophageal sphincter. Am J Otolaryngol. 2005;26:157–62.
Terre R, Valles M, Panades A, Mearin F. Long-lasting effect of a single botulinum toxin injection in the treatment of oropharyngeal dysphagia secondary to upper esophageal sphincter dysfunction: a pilot study. Scand J Gastroenterol. 2008;43:1296–303.
Alfonsi E, Merlo IM, Ponzio M, Montomoli C, Tassorelli C, Biancardi C, et al. An electrophysiological approach to the diagnosis of neurogenic dysphagia: implications for botulinum toxin treatment. J Neurol Neurosurg Psychiatry. 2010;81:54–60.
Woisard-Bassols V, Alshehri S, Simonetta-Moreau M. The effects of botulinum toxin injections into the cricopharyngeus muscle of patients with cricopharyngeus dysfunction associated with pharyngo-laryngeal weakness. Eur Arch Otorhinolaryngol. 2013;270:805–15.
StGuily JL, Perie S, Willig TN, Chaussade S, Eymard B, Angelard B. Swallowing disorders in muscular diseases: functional assessment and indications of cricopharyngeal myotomy. Ear Nose Throat J. 1994;73:34–40.
Herberhold C, Walther EK. Endoscopic laser myotomy in cricopharyngeal achalasia. Adv Otorhinolaryngol. 1995;49:144–7.
Poirier NC, Bonavina L, Taillefer R, Nosadini A, Peracchia A, Duranceau A. Cricopharyngeal myotomy for neurogenic oropharyngeal dysphagia. J Thorac Cardiovasc Surg. 1997;113:233–40.
Ali GN, Wallace KL, Laundl TM, Hunt DR, deCarle DJ, Cook IJ. Predictors of outcome following cricopharyngeal disruption for pharyngeal dysphagia. Dysphagia. 1997;12:133–9.
Halvorson DJ. The treatment of cricopharyngeal dysmotility with a transmucosal cricopharyngeal myotomy using the potassium-titanly-phosphate (KTP) laser. Endoscopy. 1998;30:46–50.
Mason RJ, Bremner CG, DeMeester TR. Pharyngeal swallowing disorders selection for and outcome after myotomy. Ann Surg. 1998;228:598–608.
Lawson G, Remacle M, Jamart J, Keghian J. Endoscopic CO2 laser-assisted surgery for cricopharyngeal dysfunction. Eur Arch Otorhinolaryngol. 2003;260:475–80.
Takes RP, Hoogen FJA, Marres HAM. Endoscopic myotomy of the cricopharyngeal muscle with CO2 laser surgery. Head Neck. 2005;27:703–9.
Dauer E, Salassa J, Luga L, Kasperbauer J. Endoscopic laser vs open approach for cricopharyngeal myotomy. Otolaryngol Head Neck Surg. 2006;134:830–5.
Munoz AA, Shapiro J, Cuddy LD, Misono S, Bhattacharyya N. Videofluoroscopic findings in dysphagic patients with cricopharyngeal dysfunction: before and after open cricopharyngeal myotomy. Ann Otol Rhinol Laryngol. 2007;116:49–56.
Lawson G, Remacle M. Ins and outs of myotomy of the upper esophageal sphincter in swallowing disorders. B-ENT. 2008;10:83–9.
Kos MP, David EF, Klinkenberg-Knol EC, Mahieu HF. Long-term results of external upper esophageal sphincter myotomy for oropharyngeal dysphagia. Dysphagia. 2010;25:169–76.
Ozgursoy OB, Salassa JR. Manofluorographic and functional outcomes after endoscopic laser cricopharyngeal myotomy for cricopharyngeal bar. Otolaryngol Head Neck Surg. 2010;142:735–40.
Bachy V, Matar N, Remacle M, Jamart J, Lawson G. Long-term functional results after endoscopic cricopharyngeal myotomy with CO2 laser: a retrospective study of 32 cases. Eur Arch Otorhinolaryngol. 2013;270:965–8.
Lim RY. Endoscopic CO2 laser cricopharyngeal myotomy. J Clin Laser Med Surg. 1995;13:241–7.
Solt J, Bajor J, Moizs M, Grexa E, Horváth PO. Primary cricopharyngeal dysfunction: treatment with balloon catheter dilatation. Gastrointest Endosc. 2001;6:767–71.
Wang AY, Kadkade R, Kahrilas PJ, Hirano I. Effectiveness of esophageal dilation for symptomatic cricopharyngeal bar. Gastrointest Endosc. 2005;61:148–52.
Dou Z, Zu Y, Wen H, Wan G, Jiang L, Hu Y. The effect of different catheter balloon dilatations modes on cricopharyngeal dysfunction in patients with dysphagia. Dysphagia. 2012;27:514–20.
Campbell BH, Tuominen TC, Toohill RJ. The risk and complications of aspiration following cricopharyngeal myotomy. Am J Med. 1997;103:61S–3S.
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This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2018R1A2B6000996).
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Jang, S.H., Kim, M.S. Dysphagia in Lateral Medullary Syndrome: A Narrative Review. Dysphagia 36, 329–338 (2021). https://doi.org/10.1007/s00455-020-10158-3
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DOI: https://doi.org/10.1007/s00455-020-10158-3