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Cortical Regulation During the Early Stage of Initiation of Voluntary Swallowing in Humans

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Abstract

The aim of the present study was to reveal the spatiotemporal relations among cortical regions involved in the initiation of voluntary swallowing in humans using magnetoencephalography (MEG). As a control task, finger extension movement, which is purely voluntary, was also investigated using the same techniques. The swallowing-related activity was distributed widely for 2000 ms before the electromyogram onset of the right suprahyoid muscle; however, the finger-related activity occurred in the late stage of the recording. The cingulate cortex, the insula, and the inferior frontal gyrus were the main loci active prior to swallowing. These cortical loci coincide with those suggested by previous human brain mapping studies that investigated the brain mechanism which controls swallowing. Activation in the cingulate cortex was registered in the early stage of swallowing and could be related to the cognitive process regarding the food being safe to swallow. The activation in the insula lasted for a long time before the initiation of swallowing. This suggests that the long-lasting activation in the insula prior to swallowing is essential for the initiation of swallowing.

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Authors and Affiliations

  1. Department of Oral Medicine, Tokyo Dental College, Chiba

    Yutaka Watanabe DDS & Gen-yuki Yamane DDS, PhD

  2. Department of Anatomy, Tokyo Dental College, Chiba

    Shinichi Abe DDS, PhD

  3. Department of Conservative Dentistry and Brain Research Laboratory, Tokyo Dental College, Chiba

    Tatsuya Ishikawa DDS, PhD

  4. Division of Oral Physiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

    Yoshiaki Yamada DDS, PhD

  5. Department of Oral Medicine, Tokyo Dental College, Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa-city, Chiba, 272-8513, Japan

    Yutaka Watanabe DDS

Authors
  1. Yutaka Watanabe DDS
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  2. Shinichi Abe DDS, PhD
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  3. Tatsuya Ishikawa DDS, PhD
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  4. Yoshiaki Yamada DDS, PhD
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  5. Gen-yuki Yamane DDS, PhD
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Correspondence to Yutaka Watanabe DDS.

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Watanabe, Y., Abe, S., Ishikawa, T. et al. Cortical Regulation During the Early Stage of Initiation of Voluntary Swallowing in Humans. Dysphagia 19, 100–108 (2004). https://doi.org/10.1007/s00455-003-0509-5

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