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Activation of Cerebellum and Basal Ganglia on Volitional Swallowing Detected by Functional Magnetic Resonance Imaging

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Abstract

Although regions of the sensorimotor cortex, insula, and anterior cingulate gyrus are reported to be activated during swallowing, findings concerning contributions of the cerebellum and basal ganglia have been contradictory. We investigated cerebellar and basal ganglionic activation using functional magnetic resonance imaging (fMRI). In 11 subjects, single-shot gradient-echo echoplanar image volumes sensitive to BOLD contrast were acquired in block design fashion using an oblique orientation covering both cerebrum and cerebellum. Using statistical parametric mapping, regional activation upon swallowing was observed in the sensorimotor cortex, insula, cerebellum, putamen, globus pallidus, thalamus, anterior cingulate gyrus, supplementary motor area, superior temporal gyrus, and substancia nigra. The cerebellum was activated bilaterally, especially on the left; activation of the putamen and globus pallidus was also found bilaterally. Thus, volitional swallowing involves the cerebellum and basal ganglia as well as cortical structures. The method used was well tolerated by normal subjects and should also be applicable to patients with dysphagia.

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References

  1. S Hamdy JC Rothwell DJ Brooks D Bailey Q Aziz DG Thompson (1999) ArticleTitleIdentification of the cerebral loci processing human swallowing with H2 15O PET activation. J Neurophysiol 81 1917–1926 Occurrence Handle1:STN:280:DyaK1M3hvVaitA%3D%3D Occurrence Handle10200226

    CAS  PubMed  Google Scholar 

  2. DH Zald JV Pardo (1999) ArticleTitleThe functional neuroanatomy of voluntary swallowing. Ann Neurol 46 281–286 Occurrence Handle10.1002/1531-8249(199909)46:3<281::AID-ANA2>3.3.CO;2-C Occurrence Handle1:STN:280:DyaK1MvgvF2rsQ%3D%3D Occurrence Handle10482257

    Article  CAS  PubMed  Google Scholar 

  3. S Hamdy DJ Mikulis A Crawley S Xue H Lau S Henry NE Diamant (1999) ArticleTitleCortical activation during human volitional swallowing: an event-related fMRI study. Am J physiol Gastrointest Liver Physiol 277 G219–G225 Occurrence Handle1:CAS:528:DyaK1MXkslKnsbs%3D

    CAS  Google Scholar 

  4. K Mosier R Patel WC Liu A Kalnin J Maldjian S Baredes (1999) ArticleTitleCortical representation of swallowing in normal adults: functional implications. Laryngoscope 109 1417–1423 Occurrence Handle1:STN:280:DyaK1MvivVygtw%3D%3D Occurrence Handle10499047

    CAS  PubMed  Google Scholar 

  5. RE Martin BG Goodyear JS Gati RS Menon (2001) ArticleTitleCerebral cortical representation of automatic and volitional swallowing in humans. J Neurophysiol 85 938–950 Occurrence Handle1:STN:280:DC%2BD3M3htlyntA%3D%3D Occurrence Handle11160524

    CAS  PubMed  Google Scholar 

  6. MK Kern S Jaradeh RC Arndorfer R Shaker (2001) ArticleTitleCerebral cortical representation of reflexive and volitional swallowing in humans. Am J Physiol Gastrointest Liver Physiol 280 G345–G360

    Google Scholar 

  7. M Kern R Birn S Jaradeh A Jesmanowiz R Cox J Hyde R Shaker (2001) ArticleTitleSwallow-related cerebral cortical activity maps are not specific to deglutition. Am J Physiol Gastrointest Liver Physiol 280 G531–G538 Occurrence Handle1:CAS:528:DC%2BD3MXjtVyqtrw%3D Occurrence Handle11254478

    CAS  PubMed  Google Scholar 

  8. CJ Hartnick C Rudolph JP Willging SK Holland (2001) ArticleTitleFunctional magnetic resonance imaging of the pediatric swallow: imaging the cortex and the brainstem. Laryngoscope 111 1183–1191 Occurrence Handle1:STN:280:DC%2BD3Mrit1yjsA%3D%3D Occurrence Handle11568539

    CAS  PubMed  Google Scholar 

  9. K Mosier I Bereznaya (2001) ArticleTitleParallel cortical networks for volitional control of swallowing in humans. Exp Brain Res 140 280–289 Occurrence Handle10.1007/s002210100813 Occurrence Handle1:STN:280:DC%2BD3Mrntl2ntQ%3D%3D Occurrence Handle11681303

    Article  CAS  PubMed  Google Scholar 

  10. RM Birn PA Bandettini RW Cox A Jesmanowicz R Shaker (1998) ArticleTitleMagnetic field changes in the human brain due to swallowing or speaking. Magn Reson Med 40 55–60 Occurrence Handle1:STN:280:DyaK1czitF2qsg%3D%3D Occurrence Handle9660553

    CAS  PubMed  Google Scholar 

  11. RM Birn PA Bandettini RW Cox R Shaker (1999) ArticleTitleEvent-related fMRI of tasks involving brief motion. Hum Brain Mapp 7 106–114 Occurrence Handle10.1002/(SICI)1097-0193(1999)7:2<106::AID-HBM4>3.3.CO;2-F Occurrence Handle1:STN:280:DyaK1M7jtlGltQ%3D%3D Occurrence Handle9950068

    Article  CAS  PubMed  Google Scholar 

  12. KJ Friston AP Holmes CJ Price C Buchel KJ Worsley (1999) ArticleTitleMultisubject fMRI studies and conjunction analyses. Neuroimage 10 385–396 Occurrence Handle10.1006/nimg.1999.0484 Occurrence Handle1:STN:280:DyaK1MvisFeqsw%3D%3D Occurrence Handle10493897

    Article  CAS  PubMed  Google Scholar 

  13. J Talairach P Tournoux (1988) Cerebral structures in three-dimensional space. J Talairach P Tournoux (Eds) Co-planar stereotaxic atlas of the human brain. Thieme New York 9–18

    Google Scholar 

  14. JL Andersson C Hutton J Ashburner R Turner K Friston (2001) ArticleTitleModeling geometric deformations in EPI time series. Neuroimage 13 903–919 Occurrence Handle10.1006/nimg.2001.0746 Occurrence Handle1:STN:280:DC%2BD3MzpsFejtw%3D%3D Occurrence Handle11304086

    Article  CAS  PubMed  Google Scholar 

  15. SW Keele R Ivry (1990) ArticleTitleDoes the cerebellum provide a common computation for diverse tasks? A timing hypothesis. Ann NY Acad Sci 608 179–211 Occurrence Handle1:STN:280:By6C28nhvFU%3D Occurrence Handle2075953

    CAS  PubMed  Google Scholar 

  16. WT Thach HP Goodkin JG Keating (1992) ArticleTitleThe cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 15 403–442 Occurrence Handle1575449

    PubMed  Google Scholar 

  17. O Hikosaka H Nakahara MK Rand S Katsuyuki X Lu K Nakamura S Miyachi K Doya (1999) ArticleTitleParallel neural networks for learning sequential procedures. Trends Neurosci 22 464–471 Occurrence Handle1:CAS:528:DyaK1MXmsVWhtrg%3D Occurrence Handle10481194

    CAS  PubMed  Google Scholar 

  18. R Kaji (2001) ArticleTitleBasal ganglia as a sensory gating device for motor control. J Med Invest 48 142–146 Occurrence Handle1:STN:280:DC%2BD3MnktlGhtw%3D%3D Occurrence Handle11694953

    CAS  PubMed  Google Scholar 

  19. J Tanji (1994) ArticleTitleThe supplementary motor area in the cerebral cortex. Neurosci Res 19 251–268 Occurrence Handle1:STN:280:ByuA3sngvVU%3D Occurrence Handle8058203

    CAS  PubMed  Google Scholar 

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Correspondence to Mikio Suzuki MD.

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This work was supported by a grant-in-aid for exploratory research (13877281) awarded to M. Suzuki.

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Suzuki, M., Asada, Y., Ito, J. et al. Activation of Cerebellum and Basal Ganglia on Volitional Swallowing Detected by Functional Magnetic Resonance Imaging . Dysphagia 18, 71–77 (2003). https://doi.org/10.1007/s00455-002-0088-x

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  • DOI: https://doi.org/10.1007/s00455-002-0088-x

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