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Association between the MLH1 gene and longevity

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Abstract

Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.

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Acknowledgements

This work was supported by grants from the Korean Research Foundation for Health Science, from the National Research Laboratory Programme for Rheumatic Disease, and from the Aging and Apoptosis Research Center of KOSEF, Korea Ministry of Science and Technology.

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Author notes

  1. Dong Jo Kim

    Present address: Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO, 63108, USA

Authors and Affiliations

  1. Metabolab Inc., Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 110-799, Seoul, South Korea

    Dong Jo Kim

  2. Metabolab Inc., Cancer Research Institute, Seoul National University College of Medicine, 110-799, Seoul, South Korea

    Sang Mi Yi, Seung Yeon Lee & Heun Soo Kang

  3. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Yoon-Ho Choi

  4. National Research Lab for Rheumatologic Disease, Department of Internal Medicine, Seoul National University College of Medicine, 110-799, Seoul , South Korea

    Yeong Wook Song

  5. Department of Biochemistry and Molecular Biology, The Aging and Apoptosis Research Center, Seoul National University College of Medicine, , 28 Yongon Dong, 110-799, Seoul, South Korea

    Sang Chul Park

Authors
  1. Dong Jo Kim
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  2. Sang Mi Yi
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  3. Seung Yeon Lee
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  4. Heun Soo Kang
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  5. Yoon-Ho Choi
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  6. Yeong Wook Song
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  7. Sang Chul Park
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Corresponding author

Correspondence to Sang Chul Park.

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Kim, D.J., Yi, S.M., Lee, S.Y. et al. Association between the MLH1 gene and longevity. Hum Genet 119, 353–354 (2006). https://doi.org/10.1007/s00439-006-0148-7

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  • DOI: https://doi.org/10.1007/s00439-006-0148-7

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