Abstract.
Nitric oxide (NO) modulates transcription factors that bind specific cis-regulatory DNA responsible for coordinating the spatial and temporal patterns of gene expression that are initiated by a changing microenvironment. In this way NO helps to orchestrate gene transcription and forms the basis of functional cell responses to accommodate metabolic requirements and to coordinate endogenous defense mechanisms against a variety of stress and disease conditions. There is marked overlap between the signalling pathways triggered by NO, superoxide, and hypoxia. Understanding the redox-based regulation of signal transduction and gene expression will provide insights into how cell activities are constantly coordinated and how promising new therapies may be developed.
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Pfeilschifter, J., Eberhardt, W. & Beck, KF. Regulation of gene expression by nitric oxide. Pflügers Arch - Eur J Physiol 442, 479–486 (2001). https://doi.org/10.1007/s004240100586
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DOI: https://doi.org/10.1007/s004240100586