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Strong ion reserve: a viewpoint on acid base equilibria and buffering

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An Erratum to this article was published on 30 January 2011

Abstract

Evidence suggests that strong ions can exist reversibly bound to proteins in a pH-dependent manner and that they can be recruited into the biological solution, modulating its strong ion difference in a process that opposes the acid base disturbances imposed on the system. These recruitable strong ions represent the solution’s “strong ions”. The physiological role of these protein-bound strong ion reserve in the buffering of acid base disorders is discussed.

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Authors and Affiliations

  1. Second Department of Intensive Care Medicine, “Georgios Papanikolaou” General Hospital of Thessaloniki, 57010, Exochi, Greece

    Michalis Agrafiotis

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  1. Michalis Agrafiotis
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Correspondence to Michalis Agrafiotis.

Additional information

Communicated by Susan A. Ward.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00421-011-1846-y

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Agrafiotis, M. Strong ion reserve: a viewpoint on acid base equilibria and buffering. Eur J Appl Physiol 111, 1951–1954 (2011). https://doi.org/10.1007/s00421-010-1803-1

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  • DOI: https://doi.org/10.1007/s00421-010-1803-1

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