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Baseline thickness of macular ganglion cell complex predicts progression of visual field loss

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

Previous studies reported that the thickness of the macular ganglion cell complex (mGCC) showed good diagnostic ability for detecting glaucoma. However, its impact on the progression of visual field loss in primary open angle glaucoma (POAG) is unknown. The purpose of this study was to assess whether baseline mGCC thickness is associated with the progression of visual field loss in POAG.

Methods

Fifty-six patients with POAG were included in the study. All patients were followed for more than 2 years after baseline optical coherence tomography (OCT) measurements. They had at least five reliable Humphrey visual field tests with 30–2 Swedish Interactive Threshold Algorithm standard tests during the follow-up period. The subjects were divided into two groups according to the slope of the mean deviation (MD): the fast progression group (MD slope < −0.4 dB/y) and the slow progression group (MD slope ≥ −0.4 dB/y). Factors compared between the groups were as follows: age, baseline intraocular pressure (IOP), mean IOP during the follow-up, refraction, baseline MD, pattern standard deviation (PSD), and baseline OCT measurements.

Results

There were no significant differences between the two groups in age, baseline IOP, mean IOP during the follow-up, refraction, baseline MD or PSD, average thickness of retinal nerve fiber layer (RNFL), or disc parameters. However, the baseline mGCC thickness (average and inferior hemifield) was significantly thinner in the fast progression group than in the slow progression group (74.0 ± 7.2 μm vs. 80.3 ± 8.6 μm; 68.0 ± 6.6 μm vs. 78.2 ± 11.6 μm, respectively). Moreover, global loss volume and focal loss volume, which are parameters of mGCC, showed significantly higher rates in the fast progression group than in the slow progression group. In multivariate analysis, only mGCC thickness of the inferior hemifield was associated with disease progression (P = 0.007).

Conclusions

Baseline mGCC thickness can be predictive of progressive visual field loss in patients with POAG.

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References

  1. Quigley HA, Addicks EM, Green WR (1982) Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. Arch Ophthalmol 100:135–146

    Article  CAS  PubMed  Google Scholar 

  2. Quigley HA, Dunkelberger GR, Green WR (1989) Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol 107:453–464

    CAS  PubMed  Google Scholar 

  3. Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D (2009) Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology 116:2305–2314, e1-2

    Article  PubMed Central  PubMed  Google Scholar 

  4. Airaksinen PJ, Drance SM, Douglas GR, Mawson DK, Nieminen H (1984) Diffuse and localized nerve fiber loss in glaucoma. Am J Ophthalmol 98:566–571

    CAS  PubMed  Google Scholar 

  5. Quigley HA, Katz J, Derick RJ, Gilbert D, Sommer A (1992) An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage. Ophthalmology 99:19–28

    Article  CAS  PubMed  Google Scholar 

  6. Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Richter RC, Witt KA (1991) Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 109:77–83

    Article  CAS  PubMed  Google Scholar 

  7. Harwerth RS, Carter-Dawson L, Shen F, Smith EL 3rd, Crawford ML (1999) Ganglion cell losses underlying visual field defects from experimental glaucoma. Investig Ophthalmol Vis Sci 40:2242–2250

    CAS  Google Scholar 

  8. Kim NR, Lee ES, Seong GJ, Kim JH, An HG, Kim CY (2010) Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma. Investig Ophthalmol Vis Sci 51:4646–4651

    Article  Google Scholar 

  9. Seong M, Sung KR, Choi EH, Kang SY, Cho JW, Um TW, Kim YJ, Park SB, Hong HE, Kook MS (2010) Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma. Investig Ophthalmol Vis Sci 51:1446–1452

    Article  Google Scholar 

  10. Schulze A, Lamparter J, Pfeiffer N, Berisha F, Schmidtmann I, Hoffmann EM (2011) Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 249:1039–1045

    Article  PubMed  Google Scholar 

  11. Rolle T, Briamonte C, Curto D, Grignolo FM (2011) Ganglion cell complex and retinal nerve fiber layer measured by fourier-domain optical coherence tomography for early detection of structural damage in patients with preperimetric glaucoma. Clin Ophthalmol 5:961–969

    Article  PubMed Central  PubMed  Google Scholar 

  12. Naghizadeh F, Garas A, Vargha P, Hollo G (2012) Detection of early glaucomatous progression with different parameters of the RTVue optical coherence tomograph. J Glaucoma

  13. Sung KR, Kim S, Lee Y, Yun SC, Na JH (2011) Retinal nerve fiber layer normative classification by optical coherence tomography for prediction of future visual field loss. Investig Ophthalmol Vis Sci 52:2634–2639

    Article  Google Scholar 

  14. Lalezary M, Medeiros FA, Weinreb RN, Bowd C, Sample PA, Tavares IM, Tafreshi A, Zangwill LM (2006) Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects. Am J Ophthalmol 142:576–582

    Article  PubMed  Google Scholar 

  15. Sehi M, Bhardwaj N, Chung YS, Greenfield DS, Advanced Imaging for Glaucoma Study Group (2012) Evaluation of baseline structural factors for predicting glaucomatous visual-field progression using optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy. Eye (Lond) 26:1527–1535

    Article  CAS  Google Scholar 

  16. Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M, Early Manifest Glaucoma Trial Group (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120:1268–1279

    Article  PubMed  Google Scholar 

  17. Anderson DR, Drance SM, Schulzer M, Collaborative Normal-Tension Glaucoma Study Group (2001) Natural history of normal-tension glaucoma. Ophthalmology 108:247–253

    Article  CAS  PubMed  Google Scholar 

  18. Fukuchi T, Yoshino T, Sawada H, Seki M, Togano T, Tanaka T, Ueda J, Abe H (2010) Progression rate of total, and upper and lower visual field defects in open-angle glaucoma patients. Clin Ophthalmol 4:1315–1323

    Article  PubMed Central  PubMed  Google Scholar 

  19. Kita Y, Kita R, Nitta A, Nishimura C, Tomita G (2011) Glaucomatous eye macular ganglion cell complex thickness and its relation to temporal circumpapillary retinal nerve fiber layer thickness. Jpn J Ophthalmol 55:228–234

    Article  PubMed  Google Scholar 

  20. Lee J, Hangai M, Kimura Y, Takayama K, Kee C, Yoshimura N (2013) Measurement of macular ganglion cell layer and circumpapillary retinal nerve fiber layer to detect paracentral scotoma in early glaucoma. Graefes Arch Clin Exp Ophthalmol 251:2003–2012

    Google Scholar 

  21. Takagi ST, Kita Y, Yagi F, Tomita G (2011) Macular retinal ganglion cell complex damage in the apparently normal visual field of glaucomatous eyes with hemifield defects. J Glaucoma 21:318–325

    Article  Google Scholar 

  22. Leung CK, Cheung CY, Weinreb RN, Qiu K, Liu S, Li H, Xu G, Fan N, Pang CP, Tse KK, Lam DS (2010) Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis. Investig Ophthalmol Vis Sci 51:217–222

    Article  Google Scholar 

  23. Lee EJ, Kim TW, Weinreb RN, Park KH, Kim SH, Kim DM (2011) Trend-based analysis of retinal nerve fiber layer thickness measured by optical coherence tomography in eyes with localized nerve fiber layer defects. Investig Ophthalmol Vis Sci 52:1138–1144

    Article  Google Scholar 

  24. Leung CK, Yu M, Weinreb RN, Lai G, Xu G, Lam DS (2012) Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: patterns of retinal nerve fiber layer progression. Ophthalmology 119:1858–1866

    Article  PubMed  Google Scholar 

  25. Medeiros FA, Zangwill LM, Alencar LM, Bowd C, Sample PA, Susanna R Jr, Weinreb RN (2009) Detection of glaucoma progression with stratus OCT retinal nerve fiber layer, optic nerve head, and macular thickness measurements. Investig Ophthalmol Vis Sci 50:5741–5748

    Article  Google Scholar 

  26. Rao HL, Zangwill LM, Weinreb RN, Sample PA, Alencar LM, Medeiros FA (2010) Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis. Ophthalmology 117:1692–1699, 1699.e1

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors received no financial support, and declare that they have no financial conflicts of interests.

Conflict of interest

The authors have no proprietary interests in any of the material used in this study.

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Authors and Affiliations

  1. Department of Ophthalmology, Toho University Ohashi Medical Center, 2-17-6, Ohashi Meguro-ku, Tokyo, 153-8515, Japan

    Ayako Anraku, Nobuko Enomoto, Asuka Takeyama, Hiroyuki Ito & Goji Tomita

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  1. Ayako Anraku
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  2. Nobuko Enomoto
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  3. Asuka Takeyama
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  4. Hiroyuki Ito
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  5. Goji Tomita
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Correspondence to Ayako Anraku.

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Anraku, A., Enomoto, N., Takeyama, A. et al. Baseline thickness of macular ganglion cell complex predicts progression of visual field loss. Graefes Arch Clin Exp Ophthalmol 252, 109–115 (2014). https://doi.org/10.1007/s00417-013-2527-9

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  • DOI: https://doi.org/10.1007/s00417-013-2527-9

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