Skip to main content

Advertisement

SpringerLink
Log in

Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the diagnostic ability of Fourier-domain optical coherence tomography (FD-OCT) measurements in glaucoma patients, patients with ocular hypertension, and normal subjects.

Methods

Ninety-three participants with open-angle glaucoma (OAG), 58 patients with ocular hypertension (OHT), and 60 healthy control subjects were included in the study. All study participants underwent FD-OCT imaging. Retinal ganglion cell complex (GCC), macular thickness, peripapillary retinal nerve fiber layer thickness (RFNL), and optic nerve head parameters (ONH) were measured in each participant. The diagnostic ability was evaluated using area under the receiver operating characteristics curves (AUROC).

Results

Glaucoma patients showed a significant reduction in GCC and macular retinal thickness compared to patients with OHT and normal subjects. No differences in GCC were found between the patients with OHT and normal subjects. The best diagnostic ability in the comparison between glaucoma and normal subjects after adjusting for age was found for cup-to-disc ratio (AUROC = 0.848), RNFL average thickness (AUROC = 0.828), and GCC global loss volume (AUROC = 0.805). The diagnostic power of the best GCC, RNFL, and ONH parameter did not show differences beyond random variation (p > 0.05).

Conclusions

Imaging of the GCC using FD-OCT (RTVue-100) has a comparable diagnostic ability to RNFL and ONH measurements in distinguishing between glaucoma patients and healthy subjects. No differences were found between patients with OHT and normal subjects with regard to ONH, RNFL, and GCC parameters.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Anton A, Moreno-Montañes J, Blázquez F, Alvarez A, Martín B, Molina B (2007) Usefulness of optical coherence tomography parameters of the optic disc and the retinal nerve fiber layer to differentiate glaucomatous, ocular hypertensive, and normal eyes. BJ Glaucoma 16(1):1–8

    Article  Google Scholar 

  2. Medeiros FA, Zangwill LM, Bowd C, Vessani RM, Susanna R Jr, Weinreb RN (2005) Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol 139(1):44–55

    Article  PubMed  Google Scholar 

  3. Guedes V, Schuman JS, Hertzmark E, Wollstein G, Correnti A, Mancini R, Lederer D, Voskanian S, Velazquez L, Pakter HM, Pedut-Kloizman T, Fujimoto JG, Mattox C (2003) Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. Ophthalmology 110(1):177–189

    Article  PubMed  Google Scholar 

  4. Wollstein G, Ishikawa H, Wang J, Beaton SA, Schuman JS (2005) Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. Am J Ophthalmol 139(1):39–43

    Article  PubMed  Google Scholar 

  5. Leung CK, Chan WM, Yung WH, Ng AC, Woo J, Tsang MK, Tse RK (2005) Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study. Ophthalmology 112(3):391–400

    Article  PubMed  Google Scholar 

  6. Tan O, Li G, Lu AT, Varma R, Huang D, Advanced Imaging for Glaucoma Study Group (2008) Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis. Ophthalmology 115(6):949–956

    Article  PubMed  Google Scholar 

  7. Brusini P, Filacorda S (2006) Enhanced Glaucoma Staging System (GSS 2) for classifying functional damage in glaucoma. J Glaucoma 15(1):40–46

    Article  PubMed  Google Scholar 

  8. DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach. Biometrics 44:837–845

    Article  PubMed  CAS  Google Scholar 

  9. Ishikawa H, Stein DM, Wollstein G, Beaton S, Fujimoto JG, Schuman JS (2005) Macular segmentation with optical coherence tomography. Invest Ophthalmol Vis Sci 46(6):2012–2017

    Article  PubMed  Google Scholar 

  10. González-García AO, Vizzeri G, Bowd C, Medeiros FA, Zangwill LM, Weinreb RN (2009) Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements. Am J Ophthalmol 1067-1074, 1074.e1

  11. Menke MN, Knecht P, Sturm V, Dabov S, Funk J (2008) Reproducibility of nerve fiber layer thickness measurements using 3D Fourier-domain OCT. Invest Ophthalmol Vis Sci 49(12):5386–5391

    Article  PubMed  Google Scholar 

  12. Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D (2009) Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology 116(12):2305–2314, e1-2

    Article  PubMed  Google Scholar 

  13. Seong M, Sung KR, Choi EH, Kang SY, Cho JW, Um TW, Kim YJ, Park SB, Hong HE, Kook M (2009) Diagnostic Comparison between Macular and Peripapillary Retinal Nerve Fiber Layer Measurements by Spectral Domain Optical Coherence Tomography in Normal-Tension Glaucoma. Invest Ophthalmol Vis Sci 51(3):1446–1452

    Article  PubMed  Google Scholar 

  14. Anton A, Moreno-Montañes J, Blázquez F, Alvarez A, Martín B, Molina B (2007) Usefulness of optical coherence tomography parameters of the optic disc and the retinal nerve fiber layer to differentiate glaucomatous, ocular hypertensive, and normal eyes. J Glaucoma 16(1):1–8

    Article  PubMed  Google Scholar 

  15. Garas A, Vargha P, Holló G (2010) Reproducibility of retinal nerve fiber layer and macular thickness measurement with the RTVue-100 optical coherence tomograph. Ophthalmology 117(4):738–746

    Article  PubMed  Google Scholar 

  16. Savini G, Carbonelli M, Parisi V, Barboni P (2009) Effect of pupil dilation on retinal nerve fibre layer thickness measurements and their repeatability with Cirrus HD-OCT. Eye (Lond) 24(9):1503–1508

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University Medical Center Mainz, Langenbeckstraße 1, 55131, Mainz, Germany

    Andreas Schulze, Julia Lamparter, Norbert Pfeiffer, Fatmire Berisha & Esther M. Hoffmann

  2. Department of Medical Biometry, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Obere Zahlbacher Str. 69, 55131, Mainz, Germany

    Irene Schmidtmann

Authors
  1. Andreas Schulze
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julia Lamparter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Norbert Pfeiffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fatmire Berisha
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Irene Schmidtmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Esther M. Hoffmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andreas Schulze.

Additional information

Financial disclosure

The FD-OCT RTVue-100 was provided by the Optovue company (Fremont, USA) at no cost.

The authors have full control of all primary data, and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schulze, A., Lamparter, J., Pfeiffer, N. et al. Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 249, 1039–1045 (2011). https://doi.org/10.1007/s00417-010-1585-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-010-1585-5

Keywords

Search

Navigation