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Cerebral small vessel disease: neuroimaging markers and clinical implication

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Abstract

Cerebral small vessel disease (CSVD) is a broad category of cerebrovascular diseases which primarily affect the perforating arterioles, capillaries and venules with multiple distinct etiologies. In spite of distinctive pathogenesis, CSVD shares similar neuroimaging markers, including recent small subcortical infarct, lacune of presumed vascular origin, white matter hyperintensity of presumed vascular origin, perivascular space and cerebral microbleeds. The radiological features of neuroimaging markers are indicative for etiological analysis. Furthermore, in sporadic arteriosclerotic pathogenesis associated CSVD, the total CSVD burden is a significant predictor for stroke events, global cognitive impairment, psychiatric disorders and later life quality. This review aims to summarize the radiological characteristics as well as the clinical implication of CSVD markers and neuroimaging interpretation for CSVD symptomatology.

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  1. Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, 510630, Guangdong, China

    Xiaodong Chen, Yilong Shan, Wei Cai, Sanxin Liu, Mengyan Hu, Siyuan Liao, Xuehong Huang, Bingjun Zhang, Yuge Wang & Zhengqi Lu

  2. Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, No.600 Tian He Road, Guangzhou, 510630, Guangdong, China

    Jihui Wang

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  1. Xiaodong Chen
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Chen, X., Wang, J., Shan, Y. et al. Cerebral small vessel disease: neuroimaging markers and clinical implication. J Neurol 266, 2347–2362 (2019). https://doi.org/10.1007/s00415-018-9077-3

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