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Effect of high-frequency repetitive transcranial magnetic stimulation on major depressive disorder in patients with Parkinson’s disease

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Abstract

Major depressive disorder (MDD) occurs in a small proportion of patients with Parkinson’s disease (PD) and reduces their quality of life. We performed a randomized sham-controlled study to evaluate the effect of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) on MDD in patients with PD. Ten patients participated to a real-rTMS group and eight patients to a sham-rTMS group. Evaluations were performed at baseline, 2 and 6 weeks after rTMS treatment. All participants underwent examinations of depression rating scales, including the Hamilton Rating Scale, the Montgomery–Asberg Depression Rating Scale (MADRS), and the Beck Depression Inventory (BDI) and the motor part of the Unified Parkinson Disease Rating Scale (UPDRS-III). The real-rTMS group had improved scores on HRS and the MADRS after 10 sessions, and these beneficial effects persisted for 6 weeks after the initial session. The BDI score did not change immediately after the sessions. The sham-rTMS group had no significant changes in any of the depression rating scales. The UPDRS-III did not change in either group. HF-rTMS of the left DLPFC is an effective treatment for MDD in patients with PD.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2011-0014958).

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Authors and Affiliations

  1. Department of Neurology, Chung-Ang University College of Medicine, Seoul, South Korea

    Hae-Won Shin & Young C. Youn

  2. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Sun J. Chung

  3. Department of Neurology and Research Institute, Yonsei University College of Medicine, Seoul, South Korea

    Young H. Sohn

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  1. Hae-Won Shin
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Correspondence to Hae-Won Shin.

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This study has been approved by the appropriate ethics committee and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Shin, HW., Youn, Y.C., Chung, S.J. et al. Effect of high-frequency repetitive transcranial magnetic stimulation on major depressive disorder in patients with Parkinson’s disease. J Neurol 263, 1442–1448 (2016). https://doi.org/10.1007/s00415-016-8160-x

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  • DOI: https://doi.org/10.1007/s00415-016-8160-x

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