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Orofacial apraxia in corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy and Parkinson’s disease

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Abstract

Objectives

To determine whether the assessment of orofacial praxis is useful for the differential diagnosis of parkinsonian syndromes and to understand the neural mechanisms underlying OFA, searching for the respective roles of cortical and subcortical structures.

Methods

Forty-four patients were assessed: 12 with idiopathic Parkinson’s disease (IPD), 8 with multiple system atrophy (MSA), 12 with progressive supranuclear palsy (PSP) and 12 with corticobasal degeneration (CBD). An easy bedside scale was used, exploring single gestures, gestures with noise production and multiple sequential gestures. We searched for group and task effects.

Results

Patients with CBD were significantly more impaired than those with IPD, MSA or PSP (p<0.001). Our assessment was unable to distinguish between the IPD, MSA and PSP groups. There was a clear task effect in CBD with a major impairment in multiple sequential gestures (p<0.0001).

Conclusion

Assessment of orofacial praxis helps in the clinical diagnosis of CBD. Patients with IPD, MSA and PSP did not present with OFA. We suggest that the deficit in multiple sequential gestures in CBD is related to simultaneous lesions of the parietal lobule and the supplementary motor area.

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References

  1. Akashi T, Arima K, Maruyama N, Ando S, Inose T (1989) Severe cerebral atrophy in progressive supranuclear palsy: a case report. Clin Neuropathol 8:195–199

    CAS  PubMed  Google Scholar 

  2. Alexander MP, Baker E, Naeser MA, Kaplan E, Palumbo C (1992) Neuropsychological and neuroanatomical dimensions of ideomotor apraxia. Brain 115:87–107

    PubMed  Google Scholar 

  3. Basso A, Dello Salla S, Farabala M (1987) Aphasia arising from purely deep lesions. Cortex 23:29–44

    CAS  PubMed  Google Scholar 

  4. Benson DF, Sheremata WA, Bouchard R, Segarra JM, Price D, Geschwind N (1973) Conduction aphasia: a clinico-pathological study. Arch Neurol 28:339–346

    CAS  PubMed  Google Scholar 

  5. Bergeron C, Pollanen MS, Weyer L, Lang AE (1997) Cortical degeneration in progressive supranuclear palsy. A comparison with cortical-basal ganglionic degeneration. J Neuropathol Exp Neurol 56:726–734

    Google Scholar 

  6. Bhatia KP, Lee MS, Rinne JO, Revesz T, Scaravilli F, Davies L, Marsden CD (2000) Corticobasal degeneration look-alikes. Adv Neurol 82:169–182

    CAS  PubMed  Google Scholar 

  7. Boeve BF, Maraganore DM, Parisi JE, Ahlskog JE, Graff-Radford N, Caselli RJ, Dickson DW, Kokmen E, Petersen RC (1999) Pathologic heterogeneity in clinically diagnosed corticobasal degeneration. Neurology 53:795–800

    CAS  PubMed  Google Scholar 

  8. Brenneis C, Seppi K, Schocke M, Benke T, Wenning GK, Poewe W (2004) Voxel based morphometry reveals a distinct pattern of frontal atrophy in progressive supranuclear palsy. J Neurol Neurosurg Psychiatry 75:246–249

    CAS  PubMed  Google Scholar 

  9. Cordato NJ, Halliday GM, Harding AJ, Helly MA, Morris JG (2000) Regional brain atrophy in progressive supranuclear palsy and Lewy Body disease. Ann Neurol 47:718–728

    Article  CAS  PubMed  Google Scholar 

  10. Daniel SE, Bruin VMS, Lees AJ (1995) The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal. Brain 118:759–770

    PubMed  Google Scholar 

  11. Davis PH, Bergeron C, McLachlan DR (1985) Atypical presentation of progressive supranuclear palsy. Ann Neurol 17:337–343

    CAS  PubMed  Google Scholar 

  12. Durieu I, Salmon E, Destée A, Delafosse A (1996) Corticobasal degeneration (CBD) with severe buccofacial apraxia and anarthria. Mov Disord 11:165

    Google Scholar 

  13. Fayet G, Vercelletto M, Bertout C, De Kersaint-Gilly A, Feve JR (1995) Anarthrie, apraxie progressive et syndrome extrapyramidal: forme clinique particulière de dégénérescence cortico-basale? Un cas avec étude en tomographie par émission monophotonique au HMPAO Tc 99M. Rev Neurol (Paris) 151:247–250

    CAS  PubMed  Google Scholar 

  14. Feany MB, Dickson DW (1995) Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 146:1388–1396

    CAS  PubMed  Google Scholar 

  15. Frattali CM, Sonies BC (2000) Speech and swallowing disturbances in corticobasal degeneration. Adv Neurol 82:153–160

    CAS  PubMed  Google Scholar 

  16. Garraux G, Salmon E, Peigneux P, Kreisler A, Degueldre C, Lemaire C, Destee A, Franck G (2000) Voxel-based distribution of metabolic impairment in corticobasal degeneration. Mov Disord 15:894–904

    CAS  PubMed  Google Scholar 

  17. Gibb WR, Luthert PJ, Marsden CD (1990) Clinical and pathological features of corticobasal degeneration. Adv Neurology 53:51–54

    CAS  Google Scholar 

  18. Gibb WRG, Luthert PJ, Marsden CD (1989) Corticobasal degeneration. Brain 112:1171–1192

    PubMed  Google Scholar 

  19. Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ, Kaufmann H, Klockgether T, Lang AE, Lantos PL, Litvan I, Mathias CJ,Oliver E, Robertson D, Schatz I, Wenning GK (1998) Consensus statement on the diagnosis of multiple system atrophy. J Autonom Nerv Syst 74:189–192

    CAS  Google Scholar 

  20. Haaland KY, Harrington DL (1996) Hemispheric asymmetry of movement. Curr Opin Neurobiol 6:796–800

    Article  CAS  PubMed  Google Scholar 

  21. Hanna-Pladdy B, Heilman KM, Foundas AL (2001) Cortical and subcortical contributions to ideomotor apraxia: analysis of task demands and error types. Brain 124:2513–2527

    CAS  PubMed  Google Scholar 

  22. Hauw JJ, Daniel SE, Dickson D, Horoupian DS, Jellinger K, Lantos PL, McKee A, Tabaton M, Litvan I (1994) Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy) Neurology 44:2015–2019

    CAS  PubMed  Google Scholar 

  23. Heilman KM, Rothi LJ, Valenstein E (1982) Two forms of ideomotor apraxia. Neurology 32:342–346

    CAS  PubMed  Google Scholar 

  24. Heilman KM, Rothi LJG (1993) Apraxia. In: Heilman KM, Valenstein E (eds) Clinical Neuropsychology.Oxford University Press Inc, New York. NY, pp 159–160

  25. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184

    Google Scholar 

  26. Ikeda K (1997) Basic pathology of corticobasal degeneration. Neuropathology 17:127–133

    Google Scholar 

  27. Kimura D (1982) Left-hemisphere control of oral and brachial movements and their relation to communication. Philos Trans Soc Lond B298:135–149

    Google Scholar 

  28. Kompoliti K, Goetz CG, Boeve BF, Maraganore DM, Ahlskog JE, Marsden CD, Bhatia KP,Greene PE, Przedborski S, Seal EC, Burns RS, Hauser RA, Gauger LL, Factor SA, Molho ES, Riley DE (1998) Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 55:957–961

    Article  CAS  PubMed  Google Scholar 

  29. Kumar R, Bergeron C, Pollanen MS, Lang AE (1998) Cortical-basal ganglionic degeneration. In: Jankovic J, Tolosa E (eds) Parkinson’s Disease and Movement Disorders.Williams & Wilkins, Baltimore, pp 297–316

  30. Lang AE (1992) Cortical basal ganglionic degeneration presenting with “progressive loss of speech output and orofacial dyspraxia”. J Neurol Neurosurg Psychiatry 55:1101

    CAS  PubMed  Google Scholar 

  31. Lang AE, Riley DE, Bergeron C (1994) Cortical-basal ganglionic degeneration. In: Calne DB (ed) Neurodegenerative diseases. WB Saunders, Philadelphia, pp 877–894

  32. Lantos PL (1994) The neuropathology of progressive supranuclear palsy. J Neural Transm 42:137–152

    CAS  Google Scholar 

  33. Leiguarda RC, Pramstaller PP, Merello M, Starkstein S, Lees AJ, Marsden CD (1997) Apraxia in Parkinson’s disease, progressive supranuclear palsy, multiple system atrophy and neuroleptic-induced parkinsonism. Brain 120:75–90

    Article  PubMed  Google Scholar 

  34. Leiguarda R, Lees AJ, Merello M, Starkstein S, Marsden CD (1994) The nature of apraxia in corticobasal degeneration. J Neurol Neurosurg Psychiatry 57:455–459

    CAS  PubMed  Google Scholar 

  35. Litvan I, Agid Y, Goetz C, Jankovic J, Wenning GK, Brandel JP, Lai EC,Verny M, Ray-Chaudhuri K, McKee A, Jellinger K, Pearce RK, Bartko JJ (1997) Accuracy of the clinical diagnosis of corticobasal degeneration: A clinicopathologic study. Neurology 48:119–125

    CAS  PubMed  Google Scholar 

  36. Litvan I,Grimes DA, Lang AE (2000) Phenotypes and prognosis: clinicopathologic studies of corticobasal degeneration. Adv Neurol 82:183–196

    CAS  PubMed  Google Scholar 

  37. Mateer C (1978) Impairments of nonverbal oral movements after left hemisphere damage: a followup analysis of errors. Brain Lang 6:334–341

    CAS  PubMed  Google Scholar 

  38. Mateer C, Kimura D (1977) Impairment of nonverbal oral movements in aphasia. Brain Lang 4:262–276

    CAS  PubMed  Google Scholar 

  39. Merians AS, Clark M, Poizner H, Jacobs DH, Adair J, Macauley B, Rothi LJG, Heilman KM (1999) Apraxia differs in corticobasal degeneration and left-parietal stroke: A case study. 40:314–335

  40. Nagahama Y, Fukuyama H, Turjanski N, Kennedy A, Yamauchi H, Ouchi Y, Kimura J, Brooks DJ, Shibasaki H (1997) Cerebral glucose metabolism in corticobasal degeneration: Comparison with progressive supranuclear palsy and normal controls. Mov Disord 12:691–696

    CAS  PubMed  Google Scholar 

  41. Özsancak C,Auzou P, Hannequin D (1999) La dégénérescence corticobasale: Revue de la littérature. Rev Neurol (Paris) 155:1007–1020

    PubMed  Google Scholar 

  42. Özsancak C, Auzou P, Hannequin D (2000) Dysarthria and orofacial apraxia in corticobasal degeneration. Mov Disord 15:905–910

    PubMed  Google Scholar 

  43. Paulus W, Selim M (1990) Corticonigral degeneration with neuronal achromasia and basal neurofibrillary tangles. Acta Neuropathol (Berl) 81:89–94

    CAS  PubMed  Google Scholar 

  44. Pharr V, Uttl B, Stark M, Litvan I, Fantie B, Grafman J (2001) Comparison of apraxia in corticobasal degeneration and progressive supranuclear palsy. Neurology 56:957–963

    CAS  PubMed  Google Scholar 

  45. Pillon B, Blin J, Vidailhet M, Deweer B, Sirigu A, Dubois B, Agid Y (1995) The neuropsychological pattern of corticobasal degeneration: Comparison with progressive supranuclear palsy and Alzheimer’s disease. Neurology 45:1477–1483

    CAS  PubMed  Google Scholar 

  46. Pramstaller PP, Marsden CD (1996) The basal ganglia and apraxia. Brain 119:319–340

    PubMed  Google Scholar 

  47. Raade AS, Rothi LJG, Heilman KM (1991) The relationship between buccofacial and limb apraxia. Brain Cogn 16:130–146

    CAS  PubMed  Google Scholar 

  48. Riley DE, Lang AE (2000) Clinical diagnostic criteria. Adv Neurol 82:29–34

    CAS  PubMed  Google Scholar 

  49. Rinne JO, Lee MS, Thompson PD, Marsden CD (1994) Corticobasal degeneration. A clinical study of 36 cases. Brain 117:1183–1196

    PubMed  Google Scholar 

  50. Rothi LJG, Mack L, Verfaellie M, Brown P, Heilman KM (1988) Ideomotor apraxia: error pattern analysis. Aphasiology 2:381–387

    Google Scholar 

  51. Schneider JA, Watts RL, Gearing M, Brewer RP, Mirra SS (1997) Corticobasal degeneration: Neuropathologic and clinical heterogeneity. Neurology 48:959–969

    CAS  PubMed  Google Scholar 

  52. Shima K, Tanji J (1998) Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements. J Neurophysiol 80:3247–3260

    CAS  PubMed  Google Scholar 

  53. Soliveri P, Monza D, Paridi D, Radice D, Grisoli M, Testa D, Savoiardo M, Girotti F (1999) Cognitive and magnetic resonance imaging aspects of corticobasal degeneration and progressive supranuclear palsy. Neurology 53:502–507

    CAS  PubMed  Google Scholar 

  54. Square PA, Martin RE (1994) The nature and treatment of neuromotor speech disorders in aphasia. In: Chapey R (ed) Language intervention strategies in adult aphasia. Williams and Wilkins, Baltimore, pp 467–499

  55. Takeuchi T, Shibayama H, Iwai K, Iwata H, Xu M, Kitoh J, Kobayashi H, Iwase S, Nakagawa M, Yamada K (1992) Progressive supranuclear palsy with widespread cerebral lesions. Clin Neuropathol 11:304–311

    CAS  PubMed  Google Scholar 

  56. Tognola G, Vignolo LA (1980) Brain lesions associated with oral apraxia in stroke patients: a clinico-neuroradiological investigation with CT scan. Neuropsychologia 18:257–272

    CAS  PubMed  Google Scholar 

  57. Vargha-Khadem F, Watkins KE, Price CJ, Ashburner J, Alcock KJ, Connelly A, Frackowiak RSJ, Friston KJ, Pembrey ME, Mishkin M, Gadian DG, Passingham RE (1998) Neural basis of an inherited speech and language disorder. Proc Natl Acad Sci USA 95:12695–12700

    CAS  PubMed  Google Scholar 

  58. Watts RL, Mirra SS, Richardson EP (1994) Corticobasal ganglionic degeneration. In: Marsden CD, Fahn S (eds) Movement Disorders 3. Butterworth-Heinemann, London, pp 282–299

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Authors and Affiliations

  1. Service de Neurologie et Pathologie du Mouvement, EA 2683 Clinique Neurologique, CHU de Lille, 59037, Lille Cedex, France

    Canan Ozsancak, Kathy Dujardin PhD & Alain Destée MD

  2. Service d’Explorations Fonctionnelles Neurologiques, Groupe HOPALE, 62260 Berck sur Mer & EA 2683, Clinique Neurologique, CHU, Lille, France

    Pascal Auzou MD, PhD

  3. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, WC1N 3BG London, UK

    Niall Quinn MD

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  1. Canan Ozsancak
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  2. Pascal Auzou MD, PhD
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  5. Alain Destée MD
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Correspondence to Canan Ozsancak.

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Ozsancak, C., Auzou, P., Dujardin, K. et al. Orofacial apraxia in corticobasal degeneration, progressive supranuclear palsy, multiple system atrophy and Parkinson’s disease. J Neurol 251, 1317–1323 (2004). https://doi.org/10.1007/s00415-004-0530-0

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  • DOI: https://doi.org/10.1007/s00415-004-0530-0

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