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Comparison of Chemotherapy Response with P-Glycoprotein, Multidrug Resistance-Related Protein-1, and Lung Resistance-Related Protein Expression in Untreated Small Cell Lung Cancer

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Abstract

The aim of this study was to investigate the expression of P-glycoprotein (Pgp), multidrug resistance-related protein-1 (MRP1), and lung resistance-related protein (LRP) in response to chemotherapy in untreated small cell lung cancer (SCLC). Immunohistochemical analyses were performed on multiple nonconsecutive sections of biopsy specimens to detect Pgp, MRP1, and LRP expression in 40 patients with SCLC before chemotherapeutic induction. Response to chemotherapy was evaluated by clinical and radiological methods. The patients were divided into a good response group (n = 20) and a poor response group (n = 20). No significant differences in prognostic factors (Karnofsky performance status, tumor size, or tumor stage) were found between the two groups of patients. The difference in positive Pgp and MRP1 expressions between the good and poor response groups was significant. However, the difference in LRP expression was not significant. We conclude that chemotherapy response of patients with SCLC was related to either Pgp or MRP1 but not LPR expression.

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References

  1. J Berlin JH Schiller (1995) Chemotherapy of small-cell carcinoma of the lung BE Johnson DH Johnson (Eds) Lung cancer Willey-Liss New York 247–261

    Google Scholar 

  2. I Brock DR Hipfner BS Nielsen PB Jensen RG Deeley SPC Cole (1995) ArticleTitleSequential coexpression of the multidrug resistance gene MRP and mdr1 and their products in VP-16 (Etoposide)-selected H69 small cell lung cancer cells Cancer Res 55 459–46 Occurrence Handle7834606

    PubMed  Google Scholar 

  3. Y Canitro F Bichat SP Cole et al. (1998) ArticleTitleMultidrug resistance genes (MRP) and MDR1 expression in small cell lung cancer xenografts: relationship with response to chemotherapy Cancer Lett 130 133–141 Occurrence Handle10.1016/S0304-3835(98)00128-1 Occurrence Handle9751266

    Article  PubMed  Google Scholar 

  4. Y Chuman T Sumizawa Y Takwbayashi K Niwa et al. (1996) ArticleTitleExpression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas Int J Cancer 66 274–279 Occurrence Handle10.1002/(SICI)1097-0215(19960410)66:2<274::AID-IJC23>3.0.CO;2-B Occurrence Handle8603824

    Article  PubMed  Google Scholar 

  5. SP Cole G Bhardwaj JH Gerlach et al. (1992) ArticleTitleOverexpression of a transporter gene in a multidrug-resistance human lung cancer cell line Science 258 1650–1654 Occurrence Handle1360704

    PubMed  Google Scholar 

  6. AMC Dingemans J Ark-Otte Particlevan P Valk Particlevan der et al. (1996) ArticleTitleExpression of the human major vault protein LRP in human lung cancer samples and normal lung tissues Ann Oncol 7 625–630 Occurrence Handle8879378

    PubMed  Google Scholar 

  7. TC Hsia CC Lin JJ Wang ST Ho A Kao (2002) ArticleTitleRelationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression Lung 180 173–179 Occurrence Handle10.1007/s004080000091 Occurrence Handle12177731

    Article  PubMed  Google Scholar 

  8. MA Izquierdo RH Shoemaker MJ Flens et al. (1996) ArticleTitleOverlapping phenotypes of multidrug resistance among panels of human cancer-cell lines Int J Cancer 65 230–237 Occurrence Handle10.1002/(SICI)1097-0215(19960117)65:2<230::AID-IJC17>3.0.CO;2-H Occurrence Handle8567122

    Article  PubMed  Google Scholar 

  9. J KreisholtJ M Sorensen PB Jensen BS Nielsen CB Andersen M Sehested (1998) ArticleTitleImmunohistochemical detection of DNA topoisomerases II α, p-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer Br J Cancer 77 1469–1473 Occurrence Handle9652763

    PubMed  Google Scholar 

  10. TH Kuo FY Liu CY Chuang HS Wu JJ Wang A Kao (2003) ArticleTitleTo predict response chemotherapy using technetium-99m tetrofosmin chest images in patients with untreated small cell lung cancer and compare with p-glycoprotein, multidrug resistance-related protein-1, and lung resistance-related protein expression Nucl Med Biol 30 627–632 Occurrence Handle10.1016/S0969-8051(03)00058-1 Occurrence Handle12900288

    Article  PubMed  Google Scholar 

  11. U Lassen HH Hansen (1995) Small cell carcinoma of the lung CM Haskell JS Berek (Eds) Cancer treatment W.B. Saunders Philadelphia 414–420

    Google Scholar 

  12. F Narasaki I Matsuo N Ikuno M Fukuda H Soda M Oka (1996) ArticleTitleMultidrug resistance - associated protein (MRP) gene expression in human lung cancer Anticancer Res 16 2079–2082 Occurrence Handle8712746

    PubMed  Google Scholar 

  13. MM Oken RH Creech DC Tormey et al. (1982) ArticleTitleToxicity and response criteria of the Eastern Cooperative Oncology Group Am J Clin Oncol 5 649–655 Occurrence Handle7165009

    PubMed  Google Scholar 

  14. GL Scheffer PL Wijngaard MJ Flens et al. (1995) ArticleTitleThe drug resistance-related protein LRP is the human major vault protein Nat Med 6 578–582 Occurrence Handle10.1038/nm0695-578

    Article  Google Scholar 

  15. RJ Scheper HJ Broxterman GL Scheffer et al. (1993) ArticleTitleOverexpression of a Mr 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance Cancer Res 53 1457–1459

    Google Scholar 

  16. EF Smit PE Postmus (1995) Chemotherapy of small cell. lung cancer DN Carney (Eds) Lung Cancer The Bath Press Avon, London 156–172

    Google Scholar 

  17. PR Twentyman (1995) Mechanism of drug resistance in lung cancer cells. DN, ed. Carney (Eds) Lung Cancer The Bath Press Avon, London 213–233

    Google Scholar 

  18. M Volm (1998) ArticleTitleMultidrug resistance and its reversal Anticancer Res 18 2905–2918 Occurrence Handle9713485

    PubMed  Google Scholar 

  19. X Yang M Page (1995) ArticleTitleP-glycoprotein expression in ovarian cancer cell line following treatment with cisplatin Oncol Res 7 619–624 Occurrence Handle8704279

    PubMed  Google Scholar 

Download references

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Correspondence to J.-A. Liang.

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Yeh, JJ., Hsu, NY., Hsu, WH. et al. Comparison of Chemotherapy Response with P-Glycoprotein, Multidrug Resistance-Related Protein-1, and Lung Resistance-Related Protein Expression in Untreated Small Cell Lung Cancer. Lung 183, 177–183 (2005). https://doi.org/10.1007/s00408-004-2532-1

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