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Memory and selective attention in multiple sclerosis: cross-sectional computer-based assessment in a large outpatient sample

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

Cognitive impairments may have a severe impact on everyday functioning and quality of life of patients with multiple sclerosis (MS). However, there are some methodological problems in the assessment and only a few studies allow a representative estimate of the prevalence and severity of cognitive impairments in MS patients. We applied a computer-based method, the memory and attention test (MAT), in 531 outpatients with MS, who were assessed at nine neurological practices or specialized outpatient clinics. The findings were compared with those obtained in an age-, sex- and education-matched control group of 84 healthy subjects. Episodic short-term memory was substantially decreased in the MS patients. About 20 % of them reached a score of only less than two standard deviations below the mean of the control group. The episodic short-term memory score was negatively correlated with the EDSS score. Minor but also significant impairments in the MS patients were found for verbal short-term memory, episodic working memory and selective attention. The computer-based MAT was found to be useful for a routine assessment of cognition in MS outpatients.

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References

  1. Amato MP, Zipoli V, Portaccio E (2006) Multiple-sclerosis related cognitive changes: a review of cross-sectional and longitudinal studies. J Neurol Sci 245:41–46

    Article  PubMed  Google Scholar 

  2. Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. Lancet Neurol 7:1139–1151

    Article  PubMed  Google Scholar 

  3. Rao SM, Leo GJ, Ellington L et al (1991) Cognitive dysfunction in multiple sclerosis: II. Impact on employment and social functioning. Neurology 41:692–696

    Article  CAS  PubMed  Google Scholar 

  4. Schultheis MT, Garay E, De Luca J (2001) The influence of cognitive impairment on driving performance in multiple sclerosis. Neurology 56:1089–1094

    Article  CAS  PubMed  Google Scholar 

  5. Rogers JM, Panegyres PK (2007) Cognitive impairment in multiple sclerosis: evidence-based analysis and recommendations. J Clin Neurosci 14:919–927

    Article  PubMed  Google Scholar 

  6. Ghaffar O, Feinstein A (2007) The neuropsychiatry of multiple sclerosis: a review of recent developments. Curr Opin Psychiatry 20:278–285

    PubMed  Google Scholar 

  7. Patti F, Amato MP, Trojano M et al (2009) Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the cognitive impairment in multiple sclerosis (COGIMUS) study. Mult Scler 15:779–788

    Article  CAS  PubMed  Google Scholar 

  8. Nocentini U, Pasqualetti P, Bonavita S et al (2006) Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Mult Scler 12:77–87

    Article  CAS  PubMed  Google Scholar 

  9. Adler G, Bektas M, Feger M et al (2012) Computer-based assessment of memory and attention: evaluation of the memory and attention test (MAT). Psychiatr Prax 39:79–83

    Article  PubMed  Google Scholar 

  10. Polman CH, Reingold SC, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292–302

    Article  PubMed Central  PubMed  Google Scholar 

  11. Rabin LA, Paré N, Saykin AJ (2009) Differential memory test sensitivity for diagnosing amnestic mild cognitive impairment and predicting conversion to Alzheimer’s disease. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:357–376

    Article  PubMed Central  PubMed  Google Scholar 

  12. Satori E, Edan G (2006) Assessment of cognitive dysfunction in multiple sclerosis. J Neurol Sci 245:169–175

    Article  Google Scholar 

  13. Prakash RS, Snook EM, Lewis JM et al (2008) Cognitive impairments in relapsing-remitting multiple sclerosis: a meta-analysis. Mult Scler 14:1250–1261

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Demaree HA, DeLuca J, Gaudino EA et al (1999) Speed of information processing as a key deficit in multiple sclerosis: implications for rehabilitation. J Neurol Neurosurg Psychiatry 67:661–663

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Denney DR, Gallagher KS, Lynch SG (2011) Deficits in processing speed in patients with multiple sclerosis: evidence from explicit and covert measures. Arch Clin Neuropsychol 26:110–119

    Article  PubMed  Google Scholar 

  16. Lengenfelder J, Bryant D, Diamond BJ et al (2006) Processing speed interacts with working memory efficiency in multiple sclerosis. Arch Clin Neuropsychol 21:229–238

    Article  PubMed  Google Scholar 

  17. Rosti E, Hämäläinen P, Koivisto K et al (2007) PASAT in detecting cognitive impairment in relapsing-remitting MS. Appl Neuropsychol 14:101–112

    Article  PubMed  Google Scholar 

  18. Zakzanis KK (2000) Distinct neurocognitive profiles in multiple sclerosis subtypes. Arch Clin Neuropsychol 15:115–136

    Article  CAS  PubMed  Google Scholar 

  19. Wishart H, Sharpe D (1997) Neuropsychological aspects of multiple sclerosis—a quantitative review. J Clin Exp Neuropsychol 19:810–824

    Article  CAS  PubMed  Google Scholar 

  20. Lynch SG, Parmenter BA, Denney DR (2005) The association between cognitive impairment and physical disability in multiple sclerosis. Mult Scler 11:469–476

    Article  PubMed  Google Scholar 

  21. Feuillet L, Reuter F, Audoin B et al (2007) Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler 13:124–127

    Article  CAS  PubMed  Google Scholar 

  22. Glanz BI, Holland CM, Gauthier SA et al (2007) Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler 13:1004–1010

    Article  CAS  PubMed  Google Scholar 

  23. Brissart H, Morele E, Baumann C et al (2012) Verbal episodic memory in 426 multiple sclerosis patients: impariment in encoding, retrieval or both? Neurol Sci 33:1117–1123

    Article  CAS  PubMed  Google Scholar 

  24. Thornton AE, Raz N (1997) Memory impairment in multiple sclerosis: a quantitative review. Neuropsychology 11:357–366

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The expert technical assistance of Martina Feger is gratefully acknowledged.

Conflict of interest

This study was sponsored by Novartis GmbH Nürnberg through an unrestricted research grant. The MAT is property of Dynamikos GmbH.

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Correspondence to Georg Adler.

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Adler, G., Lembach, Y. Memory and selective attention in multiple sclerosis: cross-sectional computer-based assessment in a large outpatient sample. Eur Arch Psychiatry Clin Neurosci 265, 439–443 (2015). https://doi.org/10.1007/s00406-015-0574-4

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  • DOI: https://doi.org/10.1007/s00406-015-0574-4

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