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Thyroid incidentalomas: to treat or not to treat

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Abstract

Incidental lesions of the thyroid gland are an increasing problem facing clinicians. While asymptomatic palpable lesions are detected in only 4–7% of the population, currently available imaging modalities are sensitive enough to detect lesions in 20–30% of the population. Guidelines for managing these incidentalomas are limited, largely due to lack of well-powered prospective studies. This review will address the currently available data on thyroid incidentalomas, detected through clinical examination, cross-sectional imaging, ultrasound, and PET scans. We will focus on the modalities of detection and risk of malignancy, further investigation and management options and the deficiencies therein. We propose a pragmatic algorithm when faced with this clinical dilemma under differing circumstances.

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References

  1. Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 295:2164–2167

    Article  CAS  PubMed  Google Scholar 

  2. Harach HR, Franssila KO, Wasenius VM (1985) Occult papillary carcinoma of the thyroid. A “normal” finding in Finland. A systematic autopsy study. Cancer 56:531–538

    Article  CAS  PubMed  Google Scholar 

  3. Wang C, Crapo LM (1997) The epidemiology of thyroid disease and implications for screening. Endocrinol Metab Clin North Am 26:189–218

    Article  CAS  PubMed  Google Scholar 

  4. Mortensen JD, Woolner LB, Bennett WA (1955) Gross and microscopic findings in clinically normal thyroid glands. J Clin Endocrinol Metab 15:1270–1280

    Article  CAS  PubMed  Google Scholar 

  5. Reiners C, Wegscheider K, Schicha H, Theissen P, Vaupel R, Wrbitzky R, Schumm-Draeger PM (2004) Prevalence of thyroid disorders in the working population of Germany: ultrasonography screening in 96278 unselected employees. Thyroid 14:926–932

    Article  PubMed  Google Scholar 

  6. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19:1167–1214

    Article  PubMed  Google Scholar 

  7. Atli M, Akgul M, Saryal M, Daglar G, Yasti AC, Kama NA (2006) Thyroid incidentalomas: prediction of malignancy and management. Int Surg 91:237–244

    PubMed  Google Scholar 

  8. Vander JB, Gaston EA, Dawber TR (1968) The significance of nontoxic thyroid nodules. Final report of a 15-year study of the incidence of thyroid malignancy. Ann Intern Med 69:537–540

    CAS  PubMed  Google Scholar 

  9. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA (1977) The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 7:481–493

    Article  CAS  Google Scholar 

  10. Gough J, Scott-Coombes D, Fausto Palazzo F (2008) Thyroid incidentaloma: an evidence-based assessment of management strategy. World J Surg 32:1264–1268

    Article  PubMed  Google Scholar 

  11. Gharib H, Papini E, Valcavi R, Baskin HJ, Crescenzi A, Dottorini ME, Duick DS, Guglielmi R, Hamilton CR Jr, Zeiger MA, Zini M (2006) American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract 12:63–102

    PubMed  Google Scholar 

  12. Shetty SK, Maher MM, Hahn PF, Halpern EF, Aquino SL (2006) Significance of incidental thyroid lesions detected on CT: correlation among CT, sonography, and pathology. AJR Am J Roentgenol 187:1349–1356

    Article  PubMed  Google Scholar 

  13. Youserm DM, Huang T, Loevner LA, Langlotz CP (1997) Clinical and economic impact of incidental thyroid lesions found with CT and MR. AJNR Am J Neuroradiol 18:1423–1428

    CAS  PubMed  Google Scholar 

  14. Lee SK, Rho BH (2009) Follicular thyroid carcinoma with an eggshell calcification: report of 3 cases. J Ultrasound Med 28:801–806

    PubMed  Google Scholar 

  15. Steele SR, Martin MJ, Mullenix PS, Azarow KS, Andersen CA (2005) The significance of incidental thyroid abnormalities identified during carotid duplex ultrasonography. Arch Surg 140:981–985

    Article  PubMed  Google Scholar 

  16. Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN (2006) Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Ultrasound Q 22:231–238 discussion 239-240

    Article  PubMed  Google Scholar 

  17. Are C, Hsu JF, Schoder H, Shah JP, Larson SM, Shaha AR (2007) FDG-PET detected thyroid incidentalomas: need for further investigation? Ann Surg Oncol 14:239–247

    Article  PubMed  Google Scholar 

  18. Bae JS, Chae BJ, Park WC, Kim JS, Kim SH, Jung SS, Song BJ (2009) Incidental thyroid lesions detected by FDG-PET/CT: prevalence and risk of thyroid cancer. World J Surg Oncol 7:63

    Article  PubMed  Google Scholar 

  19. Bogsrud TV, Karantanis D, Nathan MA, Mullan BP, Wiseman GA, Collins DA, Kasperbauer JL, Strome SE, Reading CC, Hay ID, Lowe VJ (2007) The value of quantifying 18F-FDG uptake in thyroid nodules found incidentally on whole-body PET-CT. Nucl Med Commun 28:373–381

    Article  PubMed  Google Scholar 

  20. Chen YK, Ding HJ, Chen KT, Chen YL, Liao AC, Shen YY, Su CT, Kao CH (2005) Prevalence and risk of cancer of focal thyroid incidentaloma identified by 18F-fluorodeoxyglucose positron emission tomography for cancer screening in healthy subjects. Anticancer Res 25:1421–1426

    PubMed  Google Scholar 

  21. Cohen MS, Arslan N, Dehdashti F, Doherty GM, Lairmore TC, Brunt LM, Moley JF (2001) Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. Surgery 130:941–946

    Article  CAS  PubMed  Google Scholar 

  22. Ishimori T, Patel PV, Wahl RL (2005) Detection of unexpected additional primary malignancies with PET/CT. J Nucl Med 46:752–757

    PubMed  Google Scholar 

  23. Kang KW, Kim SK, Kang HS, Lee ES, Sim JS, Lee IG, Jeong SY, Kim SW (2003) Prevalence and risk of cancer of focal thyroid incidentaloma identified by 18F-fluorodeoxyglucose positron emission tomography for metastasis evaluation and cancer screening in healthy subjects. J Clin Endocrinol Metab 88:4100–4104

    Article  CAS  PubMed  Google Scholar 

  24. Katz SC, Shaha A (2008) PET-associated incidental neoplasms of the thyroid. J Am Coll Surg 207:259–264

    Article  PubMed  Google Scholar 

  25. Cohen R, Bihan H, des Guetz G, Wind P, Martin A (2009) F-18 FDG PET detection of a medullary thyroid carcinoma in a patient with metastatic colonic cancer; literature review. Ann Endocrinol (Paris) 70:468-472

    Google Scholar 

  26. Choi JY, Lee KS, Kim HJ, Shim YM, Kwon OJ, Park K, Baek CH, Chung JH, Lee KH, Kim BT (2006) Focal thyroid lesions incidentally identified by integrated 18F-FDG PET/CT: clinical significance and improved characterization. J Nucl Med 47:609–615

    PubMed  Google Scholar 

  27. Are C, Hsu JF, Ghossein RA, Schoder H, Shah JP, Shaha AR (2007) Histological aggressiveness of fluorodeoxyglucose positron-emission tomogram (FDG-PET)-detected incidental thyroid carcinomas. Ann Surg Oncol 14:3210–3215

    Article  PubMed  Google Scholar 

  28. Leenhardt L, Hejblum G, Franc B, Fediaevsky LD, Delbot T, Le Guillouzic D, Menegaux F, Guillausseau C, Hoang C, Turpin G, Aurengo A (1999) Indications and limits of ultrasound-guided cytology in the management of nonpalpable thyroid nodules. J Clin Endocrinol Metab 84:24–28

    Article  CAS  PubMed  Google Scholar 

  29. Machens A, Holzhausen HJ, Dralle H (2005) The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma. Cancer 103:2269–2273

    Article  PubMed  Google Scholar 

  30. Nam-Goong IS, Kim HY, Gong G, Lee HK, Hong SJ, Kim WB, Shong YK (2004) Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clin Endocrinol (Oxf) 60:21–28

    Article  Google Scholar 

  31. Papini E, Guglielmi R, Bianchini A, Crescenzi A, Taccogna S, Nardi F, Panunzi C, Rinaldi R, Toscano V, Pacella CM (2002) Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab 87:1941–1946

    Article  CAS  PubMed  Google Scholar 

  32. Ito Y, Uruno T, Nakano K, Takamura Y, Miya A, Kobayashi K, Yokozawa T, Matsuzuka F, Kuma S, Kuma K, Miyauchi A (2003) An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid 13:381–387

    Article  PubMed  Google Scholar 

  33. Nam SY, Roh JL, Kim JS, Lee JH, Choi SH, Kim SY (2007) Focal uptake of (18)F-fluorodeoxyglucose by thyroid in patients with nonthyroidal head and neck cancers. Clin Endocrinol (Oxf) 67:135–139

    Article  Google Scholar 

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Correspondence to Alfio Ferlito.

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This paper was written by members and invitees of the International Head and Neck Scientific Group (http://www.IHNSG.com).

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Iyer, N.G., Shaha, A.R., Silver, C.E. et al. Thyroid incidentalomas: to treat or not to treat. Eur Arch Otorhinolaryngol 267, 1019–1026 (2010). https://doi.org/10.1007/s00405-010-1207-1

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  • DOI: https://doi.org/10.1007/s00405-010-1207-1

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