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Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna

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A Letter to the Editor to this article was published on 19 May 2015

Abstract

Purpose

Abnormal uterine bleeding (AUB) is one of the prevalent gynecological disorders that cause considerable morbidity and management of that plays an important role in protecting women’s health. This review focuses on medicinal plants mentioned by Avicenna, a great Iranian philosopher and physician (A.D. 980–1037), in his book Canon for treatment of AUB.

Methods

Medicinal plants mentioned in Canon for treatment of AUB were elicited and searched in electronic databases including PubMed, Scopus, Google Scholar and Cochrane library to find studies that confirmed their efficacy. Data were collected for the years 1980–2014.

Results

The findings included 23 plants belonging to 18 families. Scientific findings have revealed that these plants control AUB through four mechanisms of action including inhibition of inflammatory process, inhibition of prostaglandins production, antiproliferative activity on human cervical cancer cells (HeLa), and estrogenic activity. All of the plants exhibited anti-inflammatory activity in vitro and/or in vivo. Cuscuta chinensis and Portulaca oleracea exhibited estrogenic activity. Boswellia carteri, Lens culinaris, Myrtus communis, Polygonum aviculare, Pistacia lentiscus, and Punica granatum have revealed inhibitory activity on biosynthesis of prostaglandins. Some of the mentioned plants including: Ceratonia siliqua, Cuscuta chinensis, Cuscuta epithymum, Cydonia oblonga, Paeonia sp., Portulaca oleracea, Solanum nigrum, Rumex acetosa and Onopordum acanthium have shown antiproliferative activity on HeLa cells.

Conclusion

Investigation of traditional Iranian medicine literatures can lead to the identification of effective natural medicines for the management of AUB; however, conclusive confirmation of the efficacy and safety of these treatments needs more evaluations.

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Authors and Affiliations

  1. Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, 1417653761, Tehran, Iran

    Masumeh Mobli, Gholamreza Amin, Mannan Hajimahmoodi & Roja Rahimi

  2. Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran

    Marzieh Qaraaty

  3. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Gholamreza Amin

  4. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Ismaeil Haririan

  5. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Mannan Hajimahmoodi

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  1. Masumeh Mobli
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  2. Marzieh Qaraaty
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  3. Gholamreza Amin
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  4. Ismaeil Haririan
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  5. Mannan Hajimahmoodi
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  6. Roja Rahimi
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Correspondence to Roja Rahimi.

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Mobli, M., Qaraaty, M., Amin, G. et al. Scientific evaluation of medicinal plants used for the treatment of abnormal uterine bleeding by Avicenna. Arch Gynecol Obstet 292, 21–35 (2015). https://doi.org/10.1007/s00404-015-3629-x

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  • DOI: https://doi.org/10.1007/s00404-015-3629-x

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