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The utility of PROMIS domain measures in dermatologic care

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Abstract

Patient-reported outcome (PRO) measures play an important role in clinical care. Currently, a broad-spectrum, validated PRO measure suitable for all dermatology patients, as part of clinical care, does not exist. Patient-reported Outcome Measures Information System (PROMIS) measures track specific domain outcomes across all diseases. To assess the relevance and utility of a computer-adaptive health assessment consisting of three PROMIS domains in routine dermatologic care. This retrospective study evaluated a PROMIS health assessment, consisting of three computer-adaptive test domains (pain interference, anxiety, and depression), administered as part of routine clinical care in three dermatology clinics at an academic medical center. The primary objective was to identify clinically significant associations between high PROMIS domain scores (i.e., t score > 55) and dermatologic disease, as well as change in PROMIS domain scores in response to treatment. The majority of patients who initiated the assessment completed all domains (88.7%). In patients with atopic dermatitis, acne, hidradenitis suppurativa, and psoriasis, high PROMIS scores correlated with clinically relevant outcomes, such as severe disease, unsuccessful treatment, uncontrolled disease, and the presence of a mental health condition. PROMIS Pain Interference, anxiety and depression identified patients with severe disease, unsuccessful treatment regimens, poorly-controlled disease, and/or mental health comorbidities for multiple skin conditions. Further utilization of PROMIS domains in routine clinical care will promote patient-centered care and improve quality of care.

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Data availability

Dr. Ryan Wolf has full control of the primary data and agrees to allow the journal to review these data if requested.

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Acknowledgements

The authors would like to thank: Kathleen Fear in the UR Health Lab for her technical support, data extraction, and data organization for this project; Claire Porterfield for her technical assistance with chart review data collection and management during her summer medical research rotation; and Zachary Skabelund for his data management assistance during his summer medical research rotation.

Funding

This study was supported by the University of Rochester Department of Dermatology. No funding was received for the conduct of the study or preparation of the manuscript.

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Authors and Affiliations

  1. School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

    Fatema Esaa

  2. Department of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Box 697, Rochester, NY, 14642, USA

    James Prezzano, Alice Pentland & Julie Ryan Wolf

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  1. Fatema Esaa
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  2. James Prezzano
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  3. Alice Pentland
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  4. Julie Ryan Wolf
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Contributions

All authors of this research paper contributed to the study conception and design. All authors have directly participated in the planning, execution, or analysis of the study. Material preparation, data collection and analyses were performed by FE, Dr. JP, and Dr. JRW. The first draft of the manuscript was written by FE and all authors commented on previous versions of the manuscript. All authors of this paper have read and approved the final version submitted. The contents of this manuscript have not been previously published or copyrighted. This manuscript is not under consideration for publication by another journal. The contents of this manuscript will not be submitted or published elsewhere while acceptance by the Journal is under consideration.

Corresponding author

Correspondence to Julie Ryan Wolf.

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All authors have no conflicts of interest to disclose.

Ethics approval

This study was approved by the University of Rochester Research Subject Review Board (RSRB#: 00062591 and 00069111).

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Esaa, F., Prezzano, J., Pentland, A. et al. The utility of PROMIS domain measures in dermatologic care. Arch Dermatol Res 313, 17–24 (2021). https://doi.org/10.1007/s00403-020-02074-1

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  • DOI: https://doi.org/10.1007/s00403-020-02074-1

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