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Vasculature deprivation-induced osteonecrosis of rats’ femoral heads associated with the formation of deep surface depressions

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Background

Shallow or deep bowl-shaped depressions often develop after drilling an intraosseous conduit in the necrotic, avascular femoral head of rats. The etiopathogenesis of tissue loss at the articulation surface after a drilling procedure was elaborated in the authors’ previous reports.

Goals

To scrutinize a large collection of femoral heads of rats in order to search for similar changes in cases in which no drilling procedure was carried out.

Study

This retrospective study comprised the specimens of 386 rats with vessels-deprived osteonecrosis of the femoral heads, none of the animals having undergone a drilling procedure.

Results

Shallow or deep bowl-shaped depressions were encountered at an incidence as low as 2.8% of the femoral heads of the above mentioned 386 rats. It is not feasible to distinguish histologically the “spontaneously” arising from and drilling-related depressions.

Conclusions

No assured explanation can be offered for the evolving depressions of the surface of femoral heads of rats, which have not undergone a drilling procedure. It is hypothesized that the synovial fluid forces its way via slits in the articulation surface and bores cavities in the substance of femoral heads, which display a postosteonecrotic osteoarthritis-like disorder. The rising pressure in the arthritic joints results, firstly, in an enlargement of these cavities and, secondly, loss of fibro-cartilaginous tissue such that the cavities come to communicate with the articular space.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery B, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, P. O. Box 9602, Haifa, Israel, 31096

    Eli Peled & Chaim Zinman

  2. Department of Pathology, Bnai-Zion Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Jacob Bejar & Jochanan H. Boss

Authors
  1. Eli Peled
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  2. Jacob Bejar
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  3. Chaim Zinman
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  4. Jochanan H. Boss
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Correspondence to Eli Peled.

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Peled, E., Bejar, J., Zinman, C. et al. Vasculature deprivation-induced osteonecrosis of rats’ femoral heads associated with the formation of deep surface depressions. Arch Orthop Trauma Surg 127, 369–374 (2007). https://doi.org/10.1007/s00402-006-0258-7

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  • DOI: https://doi.org/10.1007/s00402-006-0258-7

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