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Thermoresponsive submicron-sized core–shell hydrogel particles with encapsulated olive oil

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An Erratum to this article was published on 03 September 2014

Abstract

Thermoresponsive submicron-sized core–shell hydrogel particles with incorporated olive oil were synthesised and studied. The microspheres having poly(N-isopropylacrylamide-co-methyl methacrylate) core and poly(N-isopropylacrylamide) shell were synthesised by emulsifier-free seed polymerisation method. The morphology, particle size and distribution characteristics of the core microspheres were studied with different amount of initiator, monomer–solvent ratio and polymerisation time using scanning electron microscopy and dynamic light scattering particle size analysis. The prepared core and core–shell microspheres were regularly spherical with average size of around 190.0 and 320.0 nm respectively and nearly monodispersed size distribution. Transmission electron microscopy study revealed the core–shell structure of the microspheres. The thermoresponsive transition temperature (T t) of the core–shell microspheres was determined as 33 °C by optical absorbance measurement, dynamic light scattering particle size analysis and differential scanning calorimetry. The release rate of olive oil from core–shell microspheres was accelerated by squeezing out the entrapped olive oil as the temperature was increased above T t. Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy study indicated the formation of copolymer.

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References

  1. Langer R, Peppas NA (2003) Advances in biomaterials, drug delivery and bionanotechnology. AIChE J 49:2990–3006

    Article  CAS  Google Scholar 

  2. Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K (2008) The development of microgel/nanogels for drug delivery applications. Prog Polym Sci 33:448–477

    Article  CAS  Google Scholar 

  3. Kopecek J (1984) Controlled biodegradability of polymers—a key to drug delivery systems. Biomaterials 5:19–25

    Article  CAS  Google Scholar 

  4. Roy I, Gupta MN (2003) Smart polymeric materials: emerging biochemical applications. Chem Biol 10:1161–1171

    Article  CAS  Google Scholar 

  5. Hoffman AS (2002) Hydrogels for biomedical applications. Adv Drug Deliv Rev 43:1–12

    CAS  Google Scholar 

  6. Blanco-Andujar C, Tung LD, Thanh NTK (2010) Synthesis of nanoparticles for biomedical applications. Annu Rep Prog Chem Sect A 106:553–568

    Article  CAS  Google Scholar 

  7. Lee LJ (2006) Polymer nanoengineering for biomedical applications. Ann Biomed Eng 34:75–88

    Article  Google Scholar 

  8. Heris HK, Rahmat M, Mongeau L (2012) Characterization of a hierarchical network of hyaluronic acid/gelatin composite for use as a smart injectable biomaterial. Macromol Biosci 12:202–210

    Article  CAS  Google Scholar 

  9. Abhinav P, Acharya JS, Lewis BGK (2013) Combinatorial co-encapsulation of hydrophobic molecules in poly(lactide-co-glycolide) microparticles. Biomaterials 34:3422–3430

    Article  Google Scholar 

  10. Boehm AI, Martinon I, Zerrouk R, Rump E, Fessi H (2003) Nanoprecipitation technique for the encapsulation of agrochemical active ingredients. J Microencapsul 20:433–441

    Article  CAS  Google Scholar 

  11. Devi N, Maji TK (2009) A novel microencapsulation of neem (Azadirachta Indica A.Juss.) seed oil (NSO) in polyelectrolyte complex of κ-carrageenan and chitosan. J Appl Polym Sci 113:1576–1583

    Article  CAS  Google Scholar 

  12. Yosha I, Shani A, Magdassi S (2008) Slow release of pheromones to the atmosphere from gelatin-alginate beads. J Agric Food Chem 56:8045–8049

    Article  CAS  Google Scholar 

  13. Marei AS, Soltan HR, Mousa A, Khamis A (2000) Leaching and mobility of carbofuran from granular and alginate controlled release formulations. J Agric Sci Camb 134:405–412

    Article  CAS  Google Scholar 

  14. Prasertmanakit S, Praphairaksit N, Chiangthong W, Muangsin N (2009) Ethyl cellulose microcapsules for protecting and controlled release of folic acid. AAPS Pharm Sci Tech 10:1104–1112

    Article  CAS  Google Scholar 

  15. Silva CM, Ribeiro AJ, Figueiredo M, Ferreira D, Veiga F (2006) Microencapsulation of hemoglobin in chitosan coated alginate microspheres prepared by emulsification/internal gelation. AAPS J 7:903–913

    Article  Google Scholar 

  16. Peniche C, Fernandez M, Gallardo A, Lopez-Bravo A, Roman JS (2003) Drug delivery systems based on porous chitosan/polyacrylic acid microspheres. Macromol Biosci 3:540–545

    Article  CAS  Google Scholar 

  17. Saravanan MK, Rao P (2010) Pectin–gelatin and alginate–gelatin complex coacervation for controlled drug delivery: influence of anionic polysaccharides and drugs being encapsulated on physicochemical properties of microcapsules. Carbohydr Polym 80:808–816

    Article  CAS  Google Scholar 

  18. Vaida C, Mela P, Kunna K, Sternberg K, Keul H, Moller M (2010) Microparticles for drug delivery based on functional polycaprolactones with enhanced degradability: loading of hydrophilic and hydrophobic active compounds. Macromol Biosci 10:925–933

    Article  CAS  Google Scholar 

  19. Filippousi M, Papadimitriou SA, Bikiaris DN, Pavlidou E, Angelakeris M, Zamboulis D et al (2013) Novel core–shell magnetic nanoparticles for taxol encapsulation in biodegradable and biocompatible block copolymers: preparation, characterization and release properties. Int J Pharm 448:221–230

    Article  CAS  Google Scholar 

  20. Wickline SA, Lanza GM (2003) Nanotechnology for molecular imaging and targeted therapy. Circulation 107:1092–1095

    Article  Google Scholar 

  21. Lee BZ, Wang LJ, Li D, Bhandari B, Li SJ, Lan Y et al (2009) Fabrication of starch-based microparticles by an emulsification crosslinking method. J Food Eng 92:250–254

    Article  Google Scholar 

  22. Esposito E, Cervellati F, Menegatti E, Nastruzzi C, Cortesi R (2002) Spray dried eudragit microparticles as encapsulation devices for vitamin C. Int J Pharm 242:329–334

    Article  CAS  Google Scholar 

  23. Weinbreck F, Nieuwenhuijse H, Robijn GW, Kriuf CGD (2004) Complexation of whey proteins with carrageenan. J Agric Food Chem 52:3550–3555

    Article  CAS  Google Scholar 

  24. Kirby CJ, Whittle CJ, Rigby N, Coxon DT, Law BA (1991) Stabilization of ascorbic acid by microencapsulation in liposomes. Int J Food Sci Tech 26:437–449

    Article  CAS  Google Scholar 

  25. Borm PJA, Kreyling W (2004) Toxicological hazards of inhaled nanoparticles—potential implications for drug delivery. J Nanosci Nanotechnol 4:1–11

    Article  Google Scholar 

  26. Medina C, Santos-Martinez MJ, Radomski A, Corrigan OI, Rodomski MW (2007) Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol 150:552–558

    Article  CAS  Google Scholar 

  27. Na K, Jung J, Lee J, Hyun J (2010) Thermoresponsive pore structure of biopolymer microspheres for a smart drug carrier. Langmuir 26:11165–11169

    Article  CAS  Google Scholar 

  28. Fundueanu G, Constantin M, Ascenzi P (2008) Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs. Biomaterials 29:2767–2775

    Article  CAS  Google Scholar 

  29. Wei H, Zhang X, Cheng C, Cheng SX, Zhuo RX (2007) Self-assembled, thermosensitive micelles of a star block copolymer based on PMMA and PNIPAAm for controlled drug delivery. Biomaterials 28:99–107

    Article  CAS  Google Scholar 

  30. Kim JH, Lee SB, Kim SJ, Lee YM (2002) Rapid temperature/pH response of porous alginate-g-poly(N-isopropylacrylamide) hydrogels. Polymer 43:7549–7558

    Article  CAS  Google Scholar 

  31. Huang X, Lowe TL (2005) Biodegradable thermoresponsive hydrogels for aqueous encapsulation and controlled release of hydrophilic model drugs. Biomacromolecules 6:2131–2139

    Article  CAS  Google Scholar 

  32. Zhang XZ, Wu DO, Chu CC (2004) Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials 25:3793–3805

    Article  CAS  Google Scholar 

  33. Liu L, Sheardown H (2005) Glucose permeable poly(dimethyl siloxane) poly(N-isopropylacrylamide) interpenetrating networks as ophthalmic biomaterials. Biomaterials 26:233–244

    Article  CAS  Google Scholar 

  34. Zhang Y, Yarin AL (2009) Stimuli-responsive copolymers of n-isopropyl acrylamide with enhanced longevity in water for micro- and nanofluidics, drug delivery and non-woven applications. J Mater Chem 19:4732–4739

    Article  CAS  Google Scholar 

  35. Atkin R, Davies P, Hardy J, Vincent B (2004) Preparation of aqueous core/polymer shell microcapsules by internal phase separation. Macromolecules 37:7979–7985

    Article  CAS  Google Scholar 

  36. Wei H, Zhang XZ, Zhou Y, Cheng SX, Zhuo RX (2006) Self-assembled thermoresponsive micelles of poly(N-isopropyl acrylamide-b-methyl methacrylate). Biomaterials 27:2028–2034

    Article  CAS  Google Scholar 

  37. Komarova GA, Starodubtsev SG, Khokhlov AR (2009) Investigation of physical-chemical properties of agarose hydrogels with embedded emulsions. J Phys Chem B 113:14849–14853

    Article  CAS  Google Scholar 

  38. Komarova GA, Starodubtsev SG, Lozinsky VL, Kalinina EV, Landfester K, Khokhlov AR (2008) Intelligent gels and cryogels with entrapped emulsions. Langmuir 24:4467–4469

    Article  CAS  Google Scholar 

  39. Preetz C, Rübe A, Reiche I, Hause G, Mäder K (2008) Preparation and characterization of biocompatible oil-loaded polyelectrolyte nanocapsules. Nanomedicine:NBM 4:106–114

    Article  CAS  Google Scholar 

  40. Kiritsakis A, Markakis P (1988) Olive oil: a review. Adv Food Res 31:453–482

    Article  Google Scholar 

  41. Devi N, Hazarika D, Deka C, Kakati DK (2012) Study of complex coacervation of gelatin A and sodium alginate for microencapsulation of olive oil. J Macromol Sci Part A: Pure and Appl Chem 49:936–945

    Article  CAS  Google Scholar 

  42. Sun-Waterhouse D, Zhou J, Miskelly GM, Wibisono R, Wadhwa SS (2011) Stability of encapsulated olive oil in the presence of caffeic acid. Food Chem 126:1049–1056

    Article  CAS  Google Scholar 

  43. Assmann G, de Backer G, Bagnara S, Betteridge J, Crepaldi G, Fernandez AC (1997) International consensus statement on olive oil and the Mediterranean diet: implications for health in Europe. Eur J Cancer Prev 6:418–421

    Article  CAS  Google Scholar 

  44. Owen RW, Giacosa A, Hull WE, Haubner R, Wurtele G, Spiegelhalder B et al (2000) Olive oil consumption and health: the possible role of antioxidants. Lancet Oncol 1:107–112

    Article  CAS  Google Scholar 

  45. Ozyilkan O, Colak D, Akcali Z, Basturk B (2005) Olive: Fruit of peace against cancer. Asian Pac J Cancer Prev 6:77–82

    Google Scholar 

  46. Garcia-Gonzalez DLG, Aparicio R (2010) Research in olive oil: challenges for the near future. J Agric Food Chem 58:12569–12577

    Article  CAS  Google Scholar 

  47. Xiao XC, Chu LY, Chen WM, Wang S, Xie R (2004) Preparation of submicrometer-sized monodispersed thermoresponsive core–shell hydrogel microspheres. Langmuir 20:5247–5253

    Article  CAS  Google Scholar 

  48. Santos AM, Elaissari A, Martinho JMG, Pichot C (2005) Synthesis of cationic poly(methyl methacrylate)-poly(N-isopropyl acrylamide) core–shell latexes via two-stage emulsion copolymerization. Polymer 46:1181–1188

    Article  CAS  Google Scholar 

  49. Zhang F, Wang CC (2008) Preparation of thermoresponsive core–shell polymeric microspheres and hollow NIPAM microgels. Colloid Polym Sci 286:889–895

    Article  CAS  Google Scholar 

  50. Gao H, Yang W, Min K, Zha L, Wang C, Fu S (2005) Thermosensitive poly(N-isopropylacrylamide) nanocapsules with controlled permeability. Polymer 46:1087–1093

    Article  CAS  Google Scholar 

  51. Prazeres T, Farinha JPS, Martinho JMG (2008) Control of oligonucleotide distribution on the shell of thermoresponsive polymer nanoparticles. J Phys Chem C 112:1633–1641

    Article  Google Scholar 

  52. Pinheiro JP, Moura L, Fokkink R, Farinha JPS (2012) Preparation and characterization of low dispersity anionic multiresponsive core–shell polymer nanoparticles. Langmuir 28:5802–5809

    Article  CAS  Google Scholar 

  53. Prazeres TJV, Santos AM, Martinho JMG (2004) Adsorption of oligonucleotides on PMMA/NIPAM core–shell latexes: polarity of the NIPAM shell probed by fluorescence. Langmiur 20:6834–6840

    Article  CAS  Google Scholar 

  54. Zhu H, Tao J, Wang W, Zhou Y, Li P, Li Z et al (2013) Magnetic, fluorescent, and thermo-responsive Fe3O4/rare earth incorporated poly(St-NIPAM) core–shell colloidal nanoparticles in multimodal optical/magnetic resonance imaging probes. Biomaterials 34:2296–2306

    Article  CAS  Google Scholar 

  55. Polozova A, Winnik FM (1999) Contribution of hydrogen bonding to the association of liposomes and an anionic hydrophobically modified poly(N-isopropylacrylamide). Langmuir 15:4222–4229

    Article  CAS  Google Scholar 

  56. Koga S, Sasaki S, Maeda H (2001) Effect of hydrophobic substances on the volume phase transition of N-isopropylacrylamide gels. J Phys Chem B 105:4105–4110

    Article  CAS  Google Scholar 

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Acknowledgements

The research has been sponsored by the University Grants Commission, New Delhi, India under the Dr. D.S. Kothari Post-Doctoral Fellowship Scheme. The author (N.D.) is grateful to UGC for financial assistance. The authors wish to thank SAIF, North-Eastern Hill University, Shillong for SEM and TEM analysis and UGC DAE CSR, Kolkata Centre for DLS analysis.

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  1. Department of Chemistry, Gauhati University, Assam, 781014, India

    Nirmala Devi & Dilip Kumar Kakati

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  1. Nirmala Devi
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Correspondence to Nirmala Devi.

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Devi, N., Kakati, D.K. Thermoresponsive submicron-sized core–shell hydrogel particles with encapsulated olive oil. Colloid Polym Sci 292, 2581–2596 (2014). https://doi.org/10.1007/s00396-014-3309-6

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  • DOI: https://doi.org/10.1007/s00396-014-3309-6

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