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Controlling the properties of poly(amino ester urethane)–poly(ethylene glycol)–poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel

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Abstract

A series of triblock copolymers composed of poly(ethylene glycol) (PEG) and poly(β-amino ester urethane) (PAEU) was synthesized and characterized. Its aqueous solution can be used as a non-cytotoxic, biodegradable, and pH/temperature-sensitive hydrogel system. The copolymer solutions exhibited sol-to-gel and gel-to-sol transitions with increasing pH and temperature, respectively. The properties of this hydrogel system, such as its sol–gel transition diagram, mechanical properties, and degradation rate, can be controlled by modulating the PEG molecular weight, PAEU block length, copolymer concentration, or structure of the monomers. The presence of urethane groups and ionized tertiary amine groups in the copolymer solution at lightly acidic pH may lead to a strong interaction of the copolymer with formulated bioactive therapeutic agents, while the existence of the gel state under physiological conditions (37 °C, pH 7.4) may enable this copolymer hydrogel to be applicable as a drug/protein carrier.

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References

  1. Huynh CT, Nguyen MK, Lee DS (2011) Macromolecules 44:6629

    Article  CAS  Google Scholar 

  2. He C, Kim SW, Lee DS (2008) J Control Release 127:189

    Article  CAS  Google Scholar 

  3. Zhang Y, Tao L, Li S, Wei Y (2011) Biomacromolecules 12:2894

    Article  CAS  Google Scholar 

  4. Gil ES, Hudson SM (2004) Prog Polym Sci 29:1173

    Article  CAS  Google Scholar 

  5. Lee F, Chung JE, Kurisawa M (2009) J Control Release 134:186

    Article  CAS  Google Scholar 

  6. Peppas NA, Hilt JZ, Khademhosseini A, Langer R (2006) Adv Mater 18:1345

    Article  CAS  Google Scholar 

  7. Nguyen MK, Lee DS (2010) Macromol Biosci 10:563

    Article  CAS  Google Scholar 

  8. Ulijn RV, Bibi N, Jayawarna V, Thornton PD, Todd SJ, Mart RJ, Smith AM, Gough JE (2007) Mater Today 10:40

    Article  CAS  Google Scholar 

  9. Satarkar NS, Biswal D, Hilt JZ (2010) Soft Matter 6:2364

    Article  CAS  Google Scholar 

  10. Alexander C, Shakesheff KM (2006) Adv Mater 18:3321

    Article  CAS  Google Scholar 

  11. Miyata T, Uragami T, Nakamae K (2002) Adv Drug Delivery Rev 54:79

    Article  CAS  Google Scholar 

  12. Langer R, Tirrell DA (2004) Nature 428:487

    Article  CAS  Google Scholar 

  13. Nguyen MK, Huynh CT, Gao GH, Kim JH, Huynh DP, Chae SY, Lee KC, Lee DS (2011) Soft Matter 7:2994

    Article  CAS  Google Scholar 

  14. Huynh CT, Nguyen MK, Kim JH, Kang SW, Kim BS, Huynh DP, Lee DS (2011) Soft Matter 7:4974

    Article  CAS  Google Scholar 

  15. Popescu M-T, Mourtas S, Pampalakis G, Antimisiaris SG, Tsitsilianis C (2011) Biomacromolecules 12:3023

    Article  CAS  Google Scholar 

  16. Zhang Z, Lai Y, Yu L, Ding J (2010) Biomaterials 31:7873

    Article  CAS  Google Scholar 

  17. Wang F, Li Z, Khan M, Tamama K, Kuppusamy P, Wagner WR, Sen CK, Guan J (2010) Acta Biomater 6:1978

    Article  CAS  Google Scholar 

  18. Park D, Wu W, Wang Y (2011) Biomaterials 32:777

    Article  CAS  Google Scholar 

  19. Yu L, Ding J (2008) Chem Soc Rev 37:1473

    Article  CAS  Google Scholar 

  20. Tsitsilianis C (2010) Soft Matter 6:2372

    Article  CAS  Google Scholar 

  21. Kopeček J (2007) Biomaterials 28:5185

    Article  Google Scholar 

  22. Hoare TR, Kohane DS (2008) Polymer 49:1993

    Article  CAS  Google Scholar 

  23. Chen J-P, Cheng T-H (2006) Macromol Biosci 12:1026

    Article  Google Scholar 

  24. Zhou HY, Chen XG, Kong M, Liu CS, Cha DS, Kennedy JF (2008) Carbohydr Polym 73:265

    Article  CAS  Google Scholar 

  25. Park M-R, Chun C-J, Ahn S-W, Ki M-H, Cho C-S, Song S-C (2010) J Control Release 147:359

    Article  CAS  Google Scholar 

  26. Park M-R, Chun C-J, Ahn S-W, Ki M-H, Cho C-S, Song S-C (2010) Biomaterials 31:1349

    Article  CAS  Google Scholar 

  27. Jeong B, Bae YH, Lee DS, Kim SW (1997) Nature 388:860

    Article  CAS  Google Scholar 

  28. Chung M, Im SJ, Choi YM, Park K, Huh KM, Park K-H (2007) J Control Release 124:51

    Article  Google Scholar 

  29. Mishra GP, Tamboli V, Mitra AK (2011) Colloid Polym Sci 289:1553

    Article  CAS  Google Scholar 

  30. Wang T, Jiang X-J, Tang Q-Z, Li X-Y, Lin T, Wu D-Q, Zhang X-Z, Okello E (2009) Acta Biomaterialia 5:2939

    Article  CAS  Google Scholar 

  31. Shim MS, Lee HT, Shim WS, Park IS, Lee HJ, Chang TH, Kim SW, Lee DS (2002) J Biomed Mater Res 61:188

    Article  CAS  Google Scholar 

  32. Kang YM, Lee SH, Lee JY, Son JS, Kim BS, Lee B, Chun HJ, Min BH, Kim JH, Kim MS (2010) Biomaterials 31:2453

    Article  CAS  Google Scholar 

  33. Zhang Z, Ni J, Chen L, Yu L, Xu J, Ding J (2011) Biomaterials 32:4725

    Article  CAS  Google Scholar 

  34. Kim HK, Shim WS, Kim SE, Lee K-H, Kang E, Kim J-H, Kim K, Kwon IC, Lee DS (2009) Tissue Eng Part A 15:923

    Article  CAS  Google Scholar 

  35. Huynh DP, Nguyen MK, Pi BS, Kim MS, Chae SY, Lee KC, Kim BS, Kim SW, Lee DS (2008) Biomaterials 29:2527

    Article  CAS  Google Scholar 

  36. Huynh DP, Im GJ, Chae SY, Lee KC, Lee DS (2009) J Control Release 137:20

    Article  CAS  Google Scholar 

  37. Shim WS, Kim J-H, Kim K, Kim Y-S, Park R-W, Kim I-S, Kwon IC, Lee DS (2007) Inter J Pharm 331:11

    Article  CAS  Google Scholar 

  38. Huynh DP, Shim WS, Kim JH, Lee DS (2006) Polymer 47:7918

    Article  CAS  Google Scholar 

  39. Dayananda K, Pi BS, Kim BS, Park TG, Lee DS (2007) Polymer 48:758

    Article  CAS  Google Scholar 

  40. Shim WS, Kim SW, Lee DS (2006) Biomacromolecules 7:1935

    Article  CAS  Google Scholar 

  41. Huynh CT, Nguyen MK, Huynh DP, Lee DS (2011) Colloid Polym Sci 289:301

    Article  CAS  Google Scholar 

  42. Nguyen MK, Huynh CT, Lee DS (2009) Polymer 50:5205

    Article  CAS  Google Scholar 

  43. Huynh DP, Nguyen MK, Kim BS, Lee DS (2009) Polymer 50:2565

    Article  CAS  Google Scholar 

  44. Huynh CT, Nguyen MK, Huynh DP, Kim SW, Lee DS (2010) Polymer 51:3843

    Article  CAS  Google Scholar 

  45. Dayananda K, He C, Park DK, Park TG, Lee DS (2008) Polymer 49:4968

    Article  CAS  Google Scholar 

  46. Nguyen MK, Park DK, Lee DS (2009) Biomacromolecules 10:728

    Article  CAS  Google Scholar 

  47. Nguyen MK, Lee DS (2010) Chem Comm 46:3583

    Article  CAS  Google Scholar 

  48. Huynh CT, Nguyen MK, Lee DS (2011) Acta Biomater 7:3123

    Article  CAS  Google Scholar 

  49. Huynh CT, Nguyen MK, Jeong IK, Kim SW, Lee DS (2012) J Biomater Sci Polym Edn 23:1091

    Article  CAS  Google Scholar 

  50. Huynh CT, Kang SW, Li Y, Kim BS, Lee DS (2011) Soft Matter 7:8984

    Article  CAS  Google Scholar 

  51. Shim WS, Kim J-H, Park H, Kim K, Kwon IC, Lee DS (2006) Biomaterials 27:5178

    Article  CAS  Google Scholar 

  52. Lee MS, Jang YL, Huynh DP, Huynh CT, Lee Y, Chae SY, Kim SH, Park TG, Lee DS, Jeong JH (2011) Macromol Biosci 11:789

    Article  CAS  Google Scholar 

  53. Gaudana R, Khurana V, Parenky A, Mitra AK (2011) J Drug Delivery, Article ID 458128, doi:10.1155/2011/458128

  54. Yang L, Cui F, Shi K, Cun D, Wang R (2009) Drug Dev Indust Pharm 35:959

    Article  CAS  Google Scholar 

  55. Yuan H, Jiang S-P, Du Y-Z, Miao J, Zhang X-G, Hu F-Q (2009) Colloid Surf B Biointer 70:248

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This study was supported by the Basic Science Research Program through a National Research Foundation of Korea grant funded by the Korean Government (MEST) (2010-0027955) and the Converging Research Center Program funded by the Ministry of Education, Science and Technology (2011K000817).

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Author notes

  1. Cong Truc Huynh

    Present address: Australian Institute for Bioengineering and Nanotechnology, Corner College and Cooper Road (Building 75), The University of Queensland, St Lucia, Brisbane, 4072, Australia

Authors and Affiliations

  1. Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do, 440-746, South Korea

    Cong Truc Huynh & Doo Sung Lee

Authors
  1. Cong Truc Huynh
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  2. Doo Sung Lee
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Correspondence to Doo Sung Lee.

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Huynh, C.T., Lee, D.S. Controlling the properties of poly(amino ester urethane)–poly(ethylene glycol)–poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel. Colloid Polym Sci 290, 1077–1086 (2012). https://doi.org/10.1007/s00396-012-2624-z

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  • DOI: https://doi.org/10.1007/s00396-012-2624-z

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