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Cardiac autonomic modulation impairments in advanced breast cancer patients

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Clinical Research in Cardiology Aims and scope Submit manuscript

A Letter to the Editors to this article was published on 28 May 2019

Abstract

Aim

To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors.

Methods and results

This cross-sectional study included women (30–69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI.

Conclusions

Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging.

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Acknowledgements

We thank all medical doctors, nurses and receptionists of hospitals participants of the present study that collaborated on patient screening and evaluation; Professor Dr. Claudio Leone for assisting on statistical analysis; PhD Cand. Renata Thais de Almeida Barbosa for helping on data collection; PhD Cand. Fernando Rocha Oliveira for assisting on HRV analysis; and the Laboratorio de Escrita Cientifica of Faculdade de Medicina do ABC for supplying Polar RS800Cx wristwatch and WearLink Wind.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Departamento de Medicina, Disciplina de Cardiologia, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, 715 Napoleão de Barros St, São Paulo, 04024002, SP, Brazil

    Claudia Arab & Celso Ferreira

  2. Departamento de Fisioterapia, Faculdade de Ciência e Tecnologia, Universidade do Estado de São Paulo, 305 Roberto Símonsen St, Presidente Prudente, SP, 19060-900, Brazil

    Luiz Carlos Marques Vanderlei

  3. Faculdade de Medicina do ABC, Laboratório de Epidemiologia e Análise de Dados, 2000 Lauro Gomes Av, Santo André, SP, 09060-870, Brazil

    Laércio da Silva Paiva

  4. Department of Physiology and Institute of Molecular Cardiology, School of Medicine, University of Louisville, Baxter Biomedical Research Building II, 590 S Preston St, Louisville, KY, 40202, USA

    Kyle Levi Fulghum

  5. Instituto do Câncer Doutor Arnaldo Vieira de Carvalho, 66 Largo do Arouche, São Paulo, SP, 01219-011, Brazil

    Carlos Elias Fristachi

  6. Departamento de Ginecologia, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    Afonso Celso Pinto Nazario & Simone Elias

  7. Centro de Referência da Saúde da Mulher, Hospital Pérola Byington, 683 Brigadeiro Luís Antônio Ave, São Paulo, SP, 01317-000, Brazil

    Luiz Henrique Gebrim

  8. Departamento de Medicina, Disciplina de Clínica Médica, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    Celso Ferreira Filho

  9. Free University of Brussels (VUB), Boulevard de la Plaine 2, 1050, Ixelles, Belgium

    Yori Gidron

Authors
  1. Claudia Arab
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  2. Luiz Carlos Marques Vanderlei
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  3. Laércio da Silva Paiva
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  4. Kyle Levi Fulghum
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  5. Carlos Elias Fristachi
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  6. Afonso Celso Pinto Nazario
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  7. Simone Elias
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  8. Luiz Henrique Gebrim
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  9. Celso Ferreira Filho
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  10. Yori Gidron
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  11. Celso Ferreira
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Corresponding author

Correspondence to Claudia Arab.

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Arab, C., Vanderlei, L.C.M., da Silva Paiva, L. et al. Cardiac autonomic modulation impairments in advanced breast cancer patients. Clin Res Cardiol 107, 924–936 (2018). https://doi.org/10.1007/s00392-018-1264-9

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  • DOI: https://doi.org/10.1007/s00392-018-1264-9

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