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A reformed surgical treatment modality for children with giant cystic craniopharyngioma

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Abstract

Objective

Surgical removal plays an important role in treating children’s craniopharyngioma. For a safe and minimally invasive craniotomy, a reformed surgical modality was proposed in this paper by combining the insertion of an Ommaya reservoir system (ORS) by stereotactic puncture, aspiration of cystic fluid in 2-day interval for consecutive 7–10 days, and the delayed tumor resection.

Patients and methods

Eleven patients (aged from 5 to 9 years old) with giant cystic craniopharyngiomas who had undergone the reformed surgical modality during November 2014 and December 2015 were collected as group A. In contrast, seven patients (aged from 5 to 11 years old) who had undergone the traditional directed operation without any prior management from January 2014 to October 2014 were collected into group B. A retrospective analysis was performed for both groups at one institution. The preoperative and postoperative clinical presentations, neuroimaging, early postoperative outcome, and the surgery-related complications of both groups were reviewed.

Results

For group A, the mean value of the maximum tumor diameters shank from 52.36 to 23.82 mm after implementing aspiration of the cystic fluid in 1-day interval for consecutive 8.23 days. Eight patients (72.73%) in group A underwent a gross total resection (GTR), while two (28.57%) patients underwent GTR in group B. The postoperative electrolyte disturbance rate and endocrine disorder rate of group B were significantly higher than those of group A (42.86 vs 36.36%; 71.43 vs 45.45%). Postoperative long-term diabetes insipidus only occurred in one patient of group B, and postoperative visual deterioration occurred in two patients of group B. Besides, one patient of group B died of severe postoperative hypothalamus dysfunction. Patients with residual tumors were applied with additional adjuvant radiotherapy, and no recurrence was observed in follow-up examinations.

Conclusion

A favorable outcome can be achieved by combining the insertion of an ORS by stereotactic puncture, aspiration of cystic fluid in 2-day interval for continuously 7–10 days, and the delayed tumor resection. This combined treatment modality maybe an effective method to treat children with giant cystic craniopharyngiomas.

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Abbreviations

ORS:

Ommaya reservoir system

GTR:

Gross total resection

ICA:

Internal carotid artery

CT:

Computed tomography

MRI:

Magnetic resonance imaging

HRT:

Hormone replacement therapy

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Authors and Affiliations

  1. Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    Wanchun Zhu, Xiang Li, Jintao He, Tao Sun, Chunde Li & Jian Gong

  2. Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China

    Jian Gong

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  1. Wanchun Zhu
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  2. Xiang Li
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Correspondence to Jian Gong.

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Funding

National Natural Science Funding (31271119) provided financial support in the form of a high-level technical talent cultivation plan in the Beijing Municipal Planning Commission Funding (2013-3-045). The sponsor had no role in the design or conduct of this research.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Informed consent was obtained from all individual participants included in the study.

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Zhu, W., Li, X., He, J. et al. A reformed surgical treatment modality for children with giant cystic craniopharyngioma. Childs Nerv Syst 33, 1491–1500 (2017). https://doi.org/10.1007/s00381-017-3473-3

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