Abstract
Objective
To present our institution’s experience in the management of childhood craniopharyngioma since 1982.
Methods
We retrospectively reviewed the records of all children diagnosed with craniopharyngioma at our children’s hospital from its opening in 1982 through to 2003. One neuroradiologist systematically reviewed the neuroimaging. Kaplan–Meier curves were used to analyze the progression-free survival and the overall survival from the time of the first definitive intervention.
Conclusions
Most children diagnosed with craniopharyngioma are long-term survivors. Survivors suffer from multiple deficits in the long term. A conservative surgical and radiotherapeutic approach and avoiding interventions that are known to cause severe morbidity may minimize these. The use of intracystic bleomycin is a strategy that allows the delay of more aggressive therapies in select patients.
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References
Baskin DS, Wilson CB (1986) Surgical management of craniopharyngiomas. A review of 74 cases. J Neurosurg 65(1):22–27
Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551
Danoff BF, Cowchock FS, Kramer S (1983) Childhood craniapharyngioma: survival, local control, endocrine and neurologic function following radiotherapy. Int J Radiat Oncol Biol Phys 9:171–175
Gonc EN, Yordam N, Ozon A, Alikasifoglu A, Kandemir N (2004) Endocrinological outcome of different treatment options in children with craniopharyngioma: a retrospective analysis of 66 cases. Pediatr Neurosurg 40:112–119
Hader WJ, Steinbok P, Hukin J, Fryer C (2000) Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg 33:211–218
Laws ER Jr, Thapar K (1994) The diagnosis and management of craniopharyngioma. Growth Genet Horm 10(3):6–11
Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St. Jude children’s research hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53(3):533–542
Poretti A, Grotzer MA, Ribi K, Schonle E, Boltshauser E (2004) Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol 46:220–229
Richmond IL, Wara WM, Wilson CB (1980) Role of radiation therapy in the management of craniopharyngiomas in children. Neurosurgery 6(5):513–517
Riva D, Pantaleoni C, Devoti M, Saletti V, Nichelli F, Giorgi C (1998) Late neuropsychological and behavioural outcome of children surgically treated for craniopharyngioma. Childs Nerv Syst 14:179–184
Stripp DCH, Maity A, Janss AJ, Belasco JB, Tochner ZA, Goldwein JW, Moshang T, Rorke LB, Phillips PC, Sutton LN, Shu HG (2004) Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys 58(3):714–720
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Hukin, J., Visser, J., Sargent, M. et al. Childhood craniopharyngioma: Vancouver experience. Childs Nerv Syst 21, 758–765 (2005). https://doi.org/10.1007/s00381-005-1220-7
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DOI: https://doi.org/10.1007/s00381-005-1220-7