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Regulation of blood oxygen transport in hibernating mammals

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Abstract

Along with the periodic reductions in O2 requirements of mammalian hibernators during winter, the O2 affinity of the blood of mammalian hibernators is seasonally regulated to help match O2 supply to consumption, contributing to limit tissue oxidative stress, particularly at arousals. Specifically, mammalian hibernators consistently show an overall increase in the blood–O2 affinity, which causes a decreased O2 unloading to tissues, while having similar or lower tissue O2 tensions during hibernation. This overview explores how the decreased body temperature and concentration of red blood cell 2,3-diphosphoglycerate (DPG) that occur in hibernation contribute separately or in combination to the concurrent increase in the O2 affinity of the hemoglobin, the O2 carrier protein of the blood. Most mammalian hemoglobins are responsive to changes in DPG concentrations, including that of the hibernating brown bear, although the smaller hibernators, such as golden-mantled ground squirrel, chipmunks, and dormice, have hemoglobins with low sensitivity to DPG. While the effect of DPG on oxygenation may vary, the decrease in body temperature invariably increases hemoglobin’s O2 affinity in all hibernating species. However, the temperature sensitivity of hemoglobin oxygenation is low in hibernators compared to human, apparently due in part to endothermic allosteric quaternary transition in ground squirrels and dissociation of chloride ions in brown bears. A low heat of blood oxygenation in temporal heterotherms, like hibernators, may thus contribute to reduce heat loss, as found in regional heterotherms, like polar mammals, although the significance would be low in winter hibernation.

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Acknowledgements

We thank Roy E. Weber and three anonymous reviewers for useful comments on the manuscript. This work was funded by Danish Council for Independent Research, Natural Sciences for (Grant DFF 4181-00094 to AF).

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  1. Department of Bioscience, Aarhus University, C.F. Møllers Allè 3, 8000, Aarhus C, Denmark

    Inge G. Revsbech & Angela Fago

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Correspondence to Angela Fago.

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Communicated by F. Breukelen.

This manuscript is part of the special issue Hibernation—Guest Editors: Frank van Breukelen and Jenifer C. Utz.

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Revsbech, I.G., Fago, A. Regulation of blood oxygen transport in hibernating mammals. J Comp Physiol B 187, 847–856 (2017). https://doi.org/10.1007/s00360-017-1085-6

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