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Strukturelle Veränderungen im Verlauf der Glaukomerkrankung

Structural alterations during the course of glaucoma disease

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Zusammenfassung

Hintergrund

Strukturelle Veränderungen im Verlauf der Glaukomerkrankung betreffen zum einen Gewebe des Trabekelwerks und des Ziliarkörpers und zum anderen die Papille mit retinaler Nervenfaserschicht als primären Schädigungsort der Erkrankung.

Fragestellung

Es werden aktuelle Ergebnisse aus experimentellen Arbeiten, Tierversuchen und Messungen an humanen Augen dargestellt und diskutiert.

Ergebnisse

Es zeichnet sich immer mehr ein komplexes Bild von Gewebsveränderungen ab, die von Alter, biochemischen und mechanischen Stressfaktoren abhängen und dann zu einem graduellen, irreversiblen Umbau in Trabekelwerk und Lamina cribrosa des N. opticus führen mit der Folge neuronaler Schädigung.

Schlussfolgerung

Im Verständnis dieser Störungen liegt auch der Schlüssel für zukünftige Glaukomtherapien.

Abstract

Background

Structural changes in the course of glaucoma disease affect the trabecular meshwork and ciliary body in addition to the optic disc as the primary site of glaucoma damage.

Objectives

Latest results from experimental studies, animal models and measurements in human eyes are presented and discussed.

Results

The presenting scenario is complex with age, biochemical and mechanical stress factors leading to subsequent, irreversible tissue change in the trabecular meshwork and cribriform plate of the optic nerve, resulting in neuronal tissue loss.

Conclusion

Knowledge of these changes will be the key for future glaucoma therapies.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. C. Mardin und U. Schlötzer-Schrehardt geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Universitätsaugenklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland

    C.Y. Mardin F.E.B.O & U. Schlötzer-Schrehardt

Authors
  1. C.Y. Mardin F.E.B.O
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  2. U. Schlötzer-Schrehardt
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Corresponding author

Correspondence to C.Y. Mardin F.E.B.O.

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Mardin, C., Schlötzer-Schrehardt, U. Strukturelle Veränderungen im Verlauf der Glaukomerkrankung. Ophthalmologe 112, 410–417 (2015). https://doi.org/10.1007/s00347-014-3152-7

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  • DOI: https://doi.org/10.1007/s00347-014-3152-7

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