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The effect of labor and/or ovariectomy on rodent continence mechanism—The neuronal changes

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Abstract

Many women develop stress urinary incontinence (SUI) after childbirth, but the exact neuronal changes are largely unknown. This study is designed to identify the neuronal changes associated with pregnancy, delivery and ovariectomy. A total of 10 virgin and 48 pregnant rats were used. Cystometry and stress/sneeze tests were performed in the virgin once and the pregnant rats at certain time points. Postpartum the rats were equally grouped as follows: group I: delivery, group II: delivery + ballooning, group III: delivery + ovariectomy, group IV: delivery + ballooning + ovariectomy. Tissues from bladder, bladder neck, and urethra were analyzed by immunostaining for PGP 9.5, CGRP, SP, NPY, VIP, TH, n-NOS. We found complex innervation changes in the different tissue samples. Since the bladder neck and the mid-urethra play an important role in the continence mechanism the neuronal changes in these areas contribute to the observed functional changes.

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Authors and Affiliations

  1. Department of Urology, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany

    Karl-Dietrich Sievert

  2. Department of Urology, University of California School of Medicine, San Francisco, California, USA

    Mustafa Emre Bakircioglu, Lora Nunes & Tom F. Lue

  3. Department of Obstetrics and Gynecology Division of Reproductive Endocrinology and Fertility, The New York Hospital Medical Center of Queens, New York, NY, USA

    Tony Tsai

Authors
  1. Karl-Dietrich Sievert
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  2. Mustafa Emre Bakircioglu
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  3. Tony Tsai
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  4. Lora Nunes
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  5. Tom F. Lue
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Correspondence to Karl-Dietrich Sievert.

Additional information

Supported in part by the Deutsche Forschungsgemeinschaft (grant Si 679/1–1) and the National Health Institute of Health grant 2 R01 DK51374 and a grant from the Montgomery Street Foundation.

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Sievert, KD., Bakircioglu, M.E., Tsai, T. et al. The effect of labor and/or ovariectomy on rodent continence mechanism—The neuronal changes. World J Urol 22, 244–250 (2004). https://doi.org/10.1007/s00345-004-0444-6

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  • DOI: https://doi.org/10.1007/s00345-004-0444-6

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