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Diagnosis of bone metastases: a meta-analysis comparing 18FDG PET, CT, MRI and bone scintigraphy

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Abstract

Objective

To perform a meta-analysis to compare 18FDG PET, CT, MRI and bone scintigraphy (BS) for the diagnosis of bone metastases.

Methods

Databases including MEDLINE and EMBASE were searched for relevant original articles published from January 1995 to January 2010. Software was used to obtain pooled estimates of sensitivity, specificity and summary receiver operating characteristic curves (SROC).

Results

67 articles consisting of 145 studies fulfilled all inclusion criteria. On per-patient basis, the pooled sensitivity estimates for PET, CT, MRI and BS were 89.7%, 72.9%, 90.6% and 86.0% respectively. PET=MRI>BS>CT. (“=”indicated no significant difference, P > 0.05; “>” indicated significantly higher, P < 0.05). The pooled specificity estimates for PET, CT, MRI and BS were 96.8%, 94.8%, 95.4% and 81.4% respectively. PET = CT = MRI>BS. On per-lesion basis, the pooled sensitivity estimates for PET, CT, MRI and BS were 86.9%, 77.1%, 90.4% and 75.1% respectively. PET = MRI>BS>CT. The pooled specificity estimates for PET, CT, MRI and BS were 97.0%, 83.2%, 96.0% and 93.6% respectively. PET>MRI>BS>CT.

Conclusion

PET and MRI were found to be comparable and both significantly more accurate than CT and BS for the diagnosis of bone metastases.

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Authors and Affiliations

  1. Department of Orthopaedics, The first affiliated hospital of Soochow University, No188, Shizi Street, Suzhou, 215006, People’s Republic of China

    Hui-Lin Yang & Tao Liu

  2. Department of Radiology, The first affiliated hospital of Soochow University, Suzhou, People’s Republic of China

    Xi-Ming Wang

  3. Department of Nuclear Medicine, The first affiliated hospital of Soochow University, Suzhou, People’s Republic of China

    Sheng-Ming Deng

  4. Department of Epidemiology and Biostatistics, Public health school of Soochow University, Suzhou, People’s Republic of China

    Yong Xu

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Yang, HL., Liu, T., Wang, XM. et al. Diagnosis of bone metastases: a meta-analysis comparing 18FDG PET, CT, MRI and bone scintigraphy. Eur Radiol 21, 2604–2617 (2011). https://doi.org/10.1007/s00330-011-2221-4

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