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Development of water-soluble metallofullerenes as X-ray contrast media

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Abstract

Fullerenes are a new carbonic allotrope having a cage structure. We investigated whether fullerenes containing one or two atoms of heavy metals could be an X-ray contrast material with little adverse effects. One or two atoms of dysprosium (Dy), erbium (Er), gadolinium (Gd), europium (Eu) and lutetium (Lu) were encapsulated into fullerene (C82), which was synthesized as a polyhydroxyl form (e.g., Gd@C82(OH)n, n=40, Gd – fullerenols). They were dissolved in water at maximum soluble concentrations and subjected to CT number analysis. The CT numbers of the solutions were measured using a 4- or 16-row multidetector CT scanner. The CT number of the water-soluble metallofullerenes were 56.0 HU for Dy@C82(OH)40, 111.5 HU for Er@C82(OH)40, 58.4 HU for Gd@C82(OH)40, 100.9 HU for Eu@C82(OH)40 and 23.3 HU for Lu2@C82(OH)40. The CT numbers of the metallofullerenes investigated in the present study were not high enough to be used in the clinic in place of iodinated contrast materials. However, if nanotechnology progresses in the near future, it may prove to have a possibility as an X-ray contrast material.

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Acknowledgement

This work was supported in part by Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

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Authors and Affiliations

  1. Department of Radiology, Nagoya City University, Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Akihiko Miyamoto & Yuta Shibamoto

  2. Department of Chemistry & Institute for Advanced Research, Nagoya University, Nagoya, 464-8602, Japan

    Haruya Okimoto & Hisanori Shinohara

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  1. Akihiko Miyamoto
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  2. Haruya Okimoto
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  3. Hisanori Shinohara
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  4. Yuta Shibamoto
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Correspondence to Akihiko Miyamoto.

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Miyamoto, A., Okimoto, H., Shinohara, H. et al. Development of water-soluble metallofullerenes as X-ray contrast media. Eur Radiol 16, 1050–1053 (2006). https://doi.org/10.1007/s00330-005-0064-6

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  • DOI: https://doi.org/10.1007/s00330-005-0064-6

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