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Platelet activation and function during eltrombopag treatment in immune thrombocytopenia

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Abstract

We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombopag. Overall, platelet activation and function normalized with increasing platelet counts. However, P-selectin, which was already elevated before treatment, and PMA increased further transiently during the first weeks. The increases in P-selectin and in PMA indicate ongoing platelet activation during the early period of treatment.

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Acknowledgments

We thank Beate Eichelberger and Daniela Koren (Department of Blood Group Serology and Transfusion Medicine) for performing platelet function tests and Tanja Altreiter, MA (Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University Vienna) for proofreading the manuscript.

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Authors and Affiliations

  1. Division of Hematology and Hemostaseology, Department of Medicine I, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Johanna Haselboeck, Ingrid Pabinger, Cihan Ay & Silvia Koder

  2. Department of Bloodgroup Serology and Transfusion Medicine, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Simon Panzer

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  1. Johanna Haselboeck
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  2. Ingrid Pabinger
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  3. Cihan Ay
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  4. Silvia Koder
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  5. Simon Panzer
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Correspondence to Simon Panzer.

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Haselboeck, J., Pabinger, I., Ay, C. et al. Platelet activation and function during eltrombopag treatment in immune thrombocytopenia. Ann Hematol 91, 109–113 (2012). https://doi.org/10.1007/s00277-011-1249-5

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  • DOI: https://doi.org/10.1007/s00277-011-1249-5

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