Abstract
Ten new pentangular polyphenols, namely amexanthomycins A–J (1–10) were isolated from the strain Amycolatopsis mediterranei S699∆rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A–C (1–3) showed inhibitory activity against human DNA topoisomerases.
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Funding
This work was supported by the National Natural Science Foundation of China (81373304, 81673317), Science Foundation of Two Sides of Strait (U1405223), and Program for Changjiang Scholars and Innovative Research Team in University (IRT_17R68).
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Electronic supplementary material (ESI) available: The NMR spectra and HRESIMS of all the compounds and disruption of PKS genes.
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Li, X., Wu, X., Zhu, J. et al. Amexanthomycins A–J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA . Appl Microbiol Biotechnol 102, 689–702 (2018). https://doi.org/10.1007/s00253-017-8648-z
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DOI: https://doi.org/10.1007/s00253-017-8648-z